AutismKB 2.0

Annotation Detail for EDC4


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Basic Information Top
Gene Symbol:EDC4 ( Ge-1,HEDLS,RCD-8 )
Gene Full Name: enhancer of mRNA decapping 4
Band: 16q22.1
Quick LinksEntrez ID:23644; OMIM: 606030; Uniprot ID:EDC4_HUMAN; ENSEMBL ID: ENSG00000038358; HGNC ID: 17157
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
6Phosphoserine.
125N6-acetyllysine.
676Phosphoserine.
693Phosphothreonine.
723Phosphoserine.
725Phosphoserine.
727Phosphothreonine.
729Phosphoserine.
734Phosphoserine.
741Phosphoserine.
780Phosphoserine.
809Phosphoserine.
821Phosphothreonine.
844Phosphoserine.
871Phosphoserine.
875Phosphoserine.
879Phosphoserine.
887Phosphoserine.
892Phosphoserine.
1067Phosphoserine.
1072Phosphothreonine.
Location(AA) Modifications Resource
729Phosphoserine.Swiss-Prot 53.0
729PhosphoserinePhospho.ELM 6.0
844Phosphoserine.Swiss-Prot 53.0
875Phosphoserine (By similarity).Swiss-Prot 53.0
879Phosphoserine (By similarity).Swiss-Prot 53.0
887Phosphoserine (By similarity).Swiss-Prot 53.0
1067PhosphoserinePhospho.ELM 6.0
1067Phosphoserine.Swiss-Prot 53.0
1072Phosphothreonine.Swiss-Prot 53.0
1072PhosphothreoninePhospho.ELM 6.0
Location(AA) Modification Resource
33Phosphoserine(CDK)HMM predict
33PhosphoserineHMM predict
33Phosphoserine(CDC2)HMM predict
62N-linkedHMM predict
106O-linkedHMM predict
106Phosphoserine(CK1)HMM predict
107Phosphoserine(IKK)HMM predict
154N-linkedHMM predict
163Phosphoserine(CAMK2)HMM predict
306Phosphoserine(CDK)HMM predict
306Phosphoserine(CDC2)HMM predict
310O-linkedHMM predict
314O-linkedHMM predict
405Phosphoserine(IKK)HMM predict
405Phosphoserine(ATM)HMM predict
475Phosphothreonine(PKA)HMM predict
565Phosphoserine(ATM)HMM predict
594Phosphothreonine(MAPK)HMM predict
600Phosphothreonine(MAPK)HMM predict
609O-linkedHMM predict
611Phosphoserine(CDC2)HMM predict
615Phosphoserine(CK1)HMM predict
628Phosphoserine(CK1)HMM predict
629Phosphoserine(CK1)HMM predict
629Phosphoserine(IKK)HMM predict
637Phosphoserine(CK1)HMM predict
639O-linkedHMM predict
640Phosphoserine(IKK)HMM predict
656Phosphoserine(MAPK)HMM predict
668Phosphoserine(IKK)HMM predict
668Phosphoserine(CK1)HMM predict
672Phosphoserine(IKK)HMM predict
676Phosphoserine(CDC2)HMM predict
702O-linkedHMM predict
708Phosphoserine(CK1)HMM predict
723Phosphoserine(CDK)HMM predict
723Phosphoserine(CDC2)HMM predict
729Phosphoserine(CDC2)HMM predict
741Phosphoserine(ATM)HMM predict
780Phosphoserine(MAPK)HMM predict
807Phosphothreonine(CDK)HMM predict
816Phosphothreonine(PKC)HMM predict
824Phosphoserine(ATM)HMM predict
871Phosphoserine(ATM)HMM predict
871Phosphoserine(IKK)HMM predict
875Phosphoserine(IKK)HMM predict
879Phosphoserine(CK2)HMM predict
914Phosphoserine(CDC2)HMM predict
918Phosphoserine(MAPK)HMM predict
967Phosphoserine(ATM)HMM predict
967Phosphoserine(CK1)HMM predict
1028Phosphoserine(IKK)HMM predict
1093N-linkedHMM predict
1120Phosphoserine(IKK)HMM predict
1191O-linkedHMM predict
1214Phosphoserine(IKK)HMM predict
1252Phosphothreonine(MAPK)HMM predict
1252Phosphothreonine(CDK)HMM predict
1252PhosphothreonineHMM predict
1311S-palmitoylHMM predict
1350Phosphoserine(ATM)HMM predict
1397Phosphothreonine(CDK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014329
  • Location:chr16 66464499-66475905
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NFkBII GM15510GSE19485 66463662 66464983 1321 177
P300 T0-glioblastomaGSE21026 66464000 66464698 698 151
Rb SenescentGSE19898 66464370 66464594 224 18
VDR GM10855-UnstimGSE22484 66463651 66464977 1326 186
VDR GM10855-stimGSE22484 66463582 66465007 1425 205
VDR GM10861-UnstimGSE22484 66463884 66465092 1208 12
VDR GM10861-stimGSE22484 66463520 66464878 1358 301
p130 QuiescentGSE19898 66464301 66464622 321 38
p130 shRbQuiescentGSE19898 66464019 66464639 620 171
p130 shRbSenescentGSE19898 66464204 66464469 265 163
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 66475195 66475483 288 0
CTCF CD4SISSRdata 66475195 66475483 288 0
CTCF G2GSE9613 66474045 66474817 772 0
CTCF G2GSE9613 66475065 66475752 687 0
ETS1 JurkatGSE17954 66464050 66465100 1050 0
GABP k562GSE8489 66464802 66467494 2692 0
H3K4me3 colorectalcancer 66465168 66465805 637 0
H3ac HepG2E 66465023 66466836 1813 0
NFkBII GM10847GSE19485 66463705 66465313 1608 0
P300 T30-glioblastomaGSE21026 66464028 66465051 1023 0
PHF8 HeLaGSE20725 66464187 66464966 779 0
Rb GrowingGSE19898 66464724 66464912 188 0
USF1 HepG2E 66474382 66475235 853 0
hScc1 BcellGSE12603 66464421 66464872 451 0
hScc1 BcellGSE12603 66475031 66475510 479 0
hScc1 CdLSGSE12603 66474931 66475622 691 0
p130 SenescentGSE19898 66464781 66465088 307 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-17 hsa-mir-17 13 20215348
hsa-miR-17* hsa-mir-17 13 20215348
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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