AutismKB 2.0

Annotation Detail for POLA2


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Basic Information Top
Gene Symbol:POLA2 ( FLJ21662,FLJ37250 )
Gene Full Name: polymerase (DNA directed), alpha 2 (70kD subunit)
Band: 11q13.1
Quick LinksEntrez ID:23649; OMIM: NA; Uniprot ID:DPOA2_HUMAN; ENSEMBL ID: ENSG00000014138; HGNC ID: 30073
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
126Phosphoserine.
127Phosphothreonine.
130Phosphothreonine.
141Phosphoserine.
147Phosphoserine.
149Phosphoserine.
152Phosphoserine.
Location(AA) Modifications Resource
127Phosphothreonine.Swiss-Prot 53.0
127PhosphothreoninePhospho.ELM 6.0
130Phosphothreonine.Swiss-Prot 53.0
130PhosphothreoninePhospho.ELM 6.0
141Phosphoserine.Swiss-Prot 53.0
152Phosphoserine.Swiss-Prot 53.0
152PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
115Phosphothreonine(CDC2)HMM predict
115Phosphothreonine(CDK)HMM predict
126PhosphoserineHMM predict
126Phosphoserine(PKB)HMM predict
126Phosphoserine(PKG)HMM predict
130Phosphothreonine(MAPK)HMM predict
130Phosphothreonine(CDK)HMM predict
138Phosphoserine(IKK)HMM predict
138Phosphoserine(PKA)HMM predict
138O-linkedHMM predict
147Phosphoserine(MAPK)HMM predict
152Phosphoserine(CDC2)HMM predict
152Phosphoserine(IKK)HMM predict
154O-linkedHMM predict
156O-linkedHMM predict
156PhosphothreonineHMM predict
156Phosphothreonine(MAPK)HMM predict
158Phosphoserine(ATM)HMM predict
161Phosphotyrosine(Syk)HMM predict
279Phosphoserine(CK1)HMM predict
308N-linkedHMM predict
309Phosphothreonine(PKC)HMM predict
351Phosphothreonine(PKC)HMM predict
351O-linkedHMM predict
435Phosphotyrosine(EGFR)HMM predict
435Phosphotyrosine(SRC)HMM predict
486Phosphoserine(CK1)HMM predict
487Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002689
  • Location:chr11 64786007-64821662
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 64785416 64786422 1006 89
CTCF HelaGSE12889 64778001 64778281 280 7867
ETS1 JurkatGSE17954 64785433 64786531 1098 26
GATA3 MCF7GSE15244 64785219 64785831 612 483
HIF1 HypoHepG2 64785443 64786142 699 215
HIF1 NormHepG2 64785479 64786205 726 166
Oct1 H2O2-HelaGSE14283 64769113 64769148 35 16877
Oct1 HelaGSE14283 64769113 64769148 35 16877
Oct1 HelaGSE14283 64784149 64784180 31 1843
PHF8 293TGSE20725 64785170 64786611 1441 117
TAF k562GSE8489 64785219 64785903 684 447
p130 QuiescentGSE19898 64785512 64786495 983 4
p130 SenescentGSE19898 64785363 64786306 943 173
p130 shRbSenescentGSE19898 64774422 64774588 166 11503
p130 shRbSenescentGSE19898 64785386 64786459 1073 85
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NRSF pAbJurkat 64828728 64829257 529 7330
TFAP2C MCF7GSE21234 64825650 64826275 625 4300
p130 QuiescentGSE19898 64822266 64822465 199 703
p130 QuiescentGSE19898 64822947 64823232 285 1427
p130 SenescentGSE19898 64822339 64822628 289 821
p130 shRbSenescentGSE19898 64822870 64823505 635 1525
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 64799146 64799396 250 0
CTCF CD4SISSRdata 64799146 64799396 250 0
FOXA1 DLD1GSE12801 64799292 64799812 520 0
FOXA1 MCF7GSE15244 64786404 64786926 522 0
H3K4me2 HCT116GSE10453 64786558 64787228 670 0
H3K4me2 HCT116GSE10453 64787891 64788070 179 0
H3K4me3 colorectalcancer 64786324 64787228 904 0
H3ac HepG2E 64785219 64787228 2009 0
H3ac HepG2E 64788539 64788970 431 0
H3ac HepG2E 64800483 64800806 323 0
LIN9 G0GSE7516 64785299 64786856 1557 0
Myc K562GSE19551 64799088 64799531 443 0
NFkBII GM12892GSE19485 64803341 64804587 1246 0
Rb GrowingGSE19898 64785902 64786224 322 0
Rb QuiescentGSE19898 64785648 64786576 928 0
Rb SenescentGSE19898 64785616 64786621 1005 0
Rb shRbQuiescentGSE19898 64785885 64786219 334 0
Rb shRbSenescenceGSE19898 64785900 64786242 342 0
TAF HelaGSE8489 64786367 64787110 743 0
TFAP2C MCF7GSE21234 64808772 64809024 252 0
hScc1 CdLSGSE12603 64799159 64799547 388 0
p130 shRbQuiescentGSE19898 64785425 64786661 1236 0
p130 shRbQuiescentGSE19898 64815964 64816884 920 0
p130 G0GSE7516 64785550 64786673 1123 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1181 Unknown pSILAC miR-1 POLA2 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000014138 n_a n_a n_a "lymphoblast, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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