AutismKB 2.0

Annotation Detail for SLC7A11


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Basic Information Top
Gene Symbol:SLC7A11 ( CCBR1,xCT )
Gene Full Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
Band: 4q28.3
Quick LinksEntrez ID:23657; OMIM: 607933; Uniprot ID:XCT_HUMAN; ENSEMBL ID: ENSG00000151012; HGNC ID: 11059
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
26Phosphoserine.
314N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
26Phosphoserine.Swiss-Prot 53.0
26PhosphoserinePhospho.ELM 6.0
314N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
8O-linkedHMM predict
45Phosphothreonine(PKA)HMM predict
65Phosphoserine(CDC2)HMM predict
183Phosphoserine(CK1)HMM predict
364Phosphothreonine(MAPK)HMM predict
449O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014331
  • Location:chr4 139304699-139382952
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 139397340 139397695 355 14565
FOXA1 eGFPGSE10845 139397340 139397695 355 14565
FoxA1 MCF7MACSdata 139397174 139397519 345 14394
TAF HelaGSE8489 139399007 139399231 224 16167
hScc1 BcellGSE12603 139382823 139383136 313 27
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog ESGSE20650 139302871 139303141 270 1694
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 139375919 139376983 1064 0
CBP T30-glioblastomaGSE21026 139375732 139377087 1355 0
CTCF G2GSE9613 139323387 139323981 594 0
CTCF G2GSE9613 139336790 139337003 213 0
CTCF G2GSE9613 139381991 139382988 997 0
ER E2-MCF7GSE14664 139325834 139325884 50 0
ER E2-MCF7GSE14664 139330673 139330705 32 0
H3K4me2 HCT116GSE10453 139382142 139382859 717 0
H3ac HepG2E 139381197 139383098 1901 0
Myc K562GSE19551 139382166 139383290 1124 0
P300 T0-glioblastomaGSE21026 139375963 139377750 1787 0
P300 T30-glioblastomaGSE21026 139375738 139377327 1589 0
Pol2 GM12878GSE19551 139381913 139383316 1403 0
PolII HeLaGSE12783 139381005 139384453 3448 0
TAF HelaGSE8489 139381197 139383330 2133 0
TAF k562GSE8489 139381197 139383519 2322 0
hScc1 BcellGSE12603 139323423 139323838 415 0
hScc1 BcellGSE12603 139382030 139382414 384 0
p130 shRbSenescentGSE19898 139382468 139383384 916 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-122 hsa-mir-122 18 19296470
hsa-miR-122* hsa-mir-122 18 19296470
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1281 Unknown pSILAC miR-30 SLC7A11 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000151012 n_a n_a n_a "leukocyte, muscle cell" "malignant tumour, leukaemia"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
20234 mRNA chr4 139367803 139456936 174 mRNA SLC7A11 chr4 139449092 139520828Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018