AutismKB 2.0

Annotation Detail for TMEM2


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Basic Information Top
Gene Symbol:TMEM2 ( - )
Gene Full Name: transmembrane protein 2
Band: 9q21.13
Quick LinksEntrez ID:23670; OMIM: 605835; Uniprot ID:TMEM2_HUMAN; ENSEMBL ID: ENSG00000135048; HGNC ID: 11869
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
10Phosphoserine.
63Phosphoserine.
292N-linked (GlcNAc...) (Potential).
368Phosphotyrosine.
384Phosphotyrosine.
914N-linked (GlcNAc...) (Potential).
1234N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
No data
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_013390
  • Location:chr9 73488102-73573227
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 73587832 73588480 648 14929
CTCF CD4GSE12889 73587891 73588278 387 14857
CTCF CD4SISSRdata 73587891 73588278 387 14857
ER Breast-CancerGSE22609 73576815 73577376 561 3868
ER MCF7GSE19013 73576756 73577313 557 3807
ER MCF7GSE19013 73583994 73584889 895 11214
ER MCF7GSE19013 73587659 73588504 845 14854
P300 T30-glioblastomaGSE21026 73587763 73588582 819 14945
PHF8 293TGSE20725 73572844 73573981 1137 185
TFAP2C MCF7GSE21234 73573059 73573447 388 26
TFAP2C MCF7GSE21234 73587665 73588460 795 14835
hScc1 BcellGSE12603 73573525 73574356 831 713
hScc1 CdLSGSE12603 73573461 73574675 1214 841
hScc1 G2GSE9613 73573461 73574356 895 681
p130 SenescentGSE19898 73573000 73573471 471 8
p130 shRbQuiescentGSE19898 73573001 73573501 500 24
p63 keratinocytesGSE17611 73587652 73588592 940 14895
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 73486294 73487066 772 1423
Nanog hESGSE18292 73467816 73468788 972 19801
RARA MCF7GSE15244 73486045 73487030 985 1565
STAT1 HeLaGSE12782 73481910 73487949 6039 3173
STAT1 HeLaGSE12783 73466438 73470030 3592 19869
STAT1 HeLaGSE12783 73481944 73487883 5939 3189
Sox2 hESGSE18292 73467920 73468556 636 19865
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 73530571 73531182 611 0
CBP T30-glioblastomaGSE21026 73530403 73531415 1012 0
ER Fulvestrant-MCF7GSE14664 73543529 73543567 38 0
ER Fulvestrant-MCF7GSE14664 73546631 73546712 81 0
FOXA1 MCF7GSE15244 73563578 73564020 442 0
Fos K562GSE19551 73530617 73531016 399 0
Fos K562GSE19551 73563422 73563951 529 0
FoxA1 MCF7MACSdata 73530740 73530892 152 0
FoxA1 MCF7MACSdata 73563661 73563894 233 0
H3K4me2 HCT116GSE10453 73571375 73572461 1086 0
H3K4me3 colorectalcancer 73571447 73573011 1564 0
H3ac HepG2E 73571115 73573173 2058 0
Jun K562GSE19551 73530645 73531027 382 0
Oct1 HelaGSE14283 73512837 73512887 50 0
Oct1 HelaGSE14283 73513156 73513186 30 0
Oct1 HelaGSE14283 73515031 73515059 28 0
Oct1 HelaGSE14283 73543524 73543566 42 0
P300 T0-glioblastomaGSE21026 73530376 73531428 1052 0
P300 T30-glioblastomaGSE21026 73530480 73531439 959 0
RNAII Tamoxifen-MCF7GSE14664 73543526 73543572 46 0
SRF k562GSE8489 73489903 73490580 677 0
TFAP2C MCF7GSE21234 73530714 73531078 364 0
p130 QuiescentGSE19898 73573061 73573355 294 0
p130 shRbSenescentGSE19898 73573047 73573384 337 0
p63 keratinocytesGSE17611 73507810 73508944 1134 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 16239240
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
605 mRNA repression TRUE miR-30a-3p TMEM2 n_a 16239240
903 Unknown pSILAC let-7b TMEM2 down 50-25% 18668040
931 Unknown pSILAC LNA_let-7b TMEM2 up 25-50% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000135048 n_a n_a n_a n_a n_a
ENSG00000135048 n_a n_a n_a n_a n_a
ENSG00000135048 n_a n_a n_a n_a n_a
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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