AutismKB 2.0

Annotation Detail for SH3BP4


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Basic Information Top
Gene Symbol:SH3BP4 ( BOG25,TTP )
Gene Full Name: SH3-domain binding protein 4
Band: 2q37.2
Quick LinksEntrez ID:23677; OMIM: 605611; Uniprot ID:SH3B4_HUMAN; ENSEMBL ID: ENSG00000130147; HGNC ID: 10826
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
131Phosphoserine.
246Phosphoserine.
637Phosphoserine.
Location(AA) Modifications Resource
637Phosphoserine.Swiss-Prot 53.0
877PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
50N-linkedHMM predict
56N-linkedHMM predict
70N-linkedHMM predict
97N-linkedHMM predict
116N-linkedHMM predict
131Phosphoserine(CDC2)HMM predict
201Phosphoserine(IKK)HMM predict
205O-linkedHMM predict
206O-linkedHMM predict
211N-linkedHMM predict
215N-linkedHMM predict
246Phosphoserine(CK1)HMM predict
246Phosphoserine(IKK)HMM predict
251Phosphoserine(CK1)HMM predict
271Phosphoserine(CDC2)HMM predict
271Phosphoserine(CDK)HMM predict
306Phosphoserine(ATM)HMM predict
375Phosphoserine(MAPK)HMM predict
383Phosphoserine(PKG)HMM predict
398Phosphoserine(PKG)HMM predict
407Phosphoserine(CK1)HMM predict
420Phosphoserine(IKK)HMM predict
420Phosphoserine(CK1)HMM predict
425Phosphotyrosine(Jak)HMM predict
425Phosphotyrosine(SRC)HMM predict
431N-linkedHMM predict
544N-linkedHMM predict
547N-linkedHMM predict
553Phosphoserine(CK2)HMM predict
578Phosphoserine(ATM)HMM predict
641O-linkedHMM predict
642O-linkedHMM predict
765N-linkedHMM predict
778Phosphotyrosine(Jak)HMM predict
810N-linkedHMM predict
811N-linkedHMM predict
814N-linkedHMM predict
868Phosphoserine(PKG)HMM predict
877Phosphoserine(CDK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014521
  • Location:chr2 235525366-235629094
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 235522759 235523808 1049 2083
CTCF G2GSE9613 235508796 235509129 333 16404
CTCF G2GSE9613 235513936 235514232 296 11283
CTCF G2GSE9613 235524871 235525163 292 350
Nanog ESGSE20650 235506038 235506632 594 19032
Nanog hESGSE18292 235506103 235506559 456 19036
Oct4 hESGSE21916 235506106 235506548 442 19040
P300 T30-glioblastomaGSE21026 235522702 235524013 1311 2009
hScc1 BcellGSE12603 235510827 235511094 267 14406
hScc1 G2GSE9613 235524626 235525163 537 472
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 235629175 235629823 648 405
CTCF G2GSE9613 235635307 235635506 199 6312
CTCF G2GSE9613 235648898 235649120 222 19915
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 235525632 235525999 367 0
CTCF G2GSE9613 235531148 235531483 335 0
CTCF G2GSE9613 235540577 235541284 707 0
CTCF G2GSE9613 235548691 235548840 149 0
CTCF G2GSE9613 235552138 235552491 353 0
CTCF G2GSE9613 235565800 235566844 1044 0
CTCF G2GSE9613 235568659 235568998 339 0
CTCF G2GSE9613 235569906 235570086 180 0
CTCF G2GSE9613 235570787 235571142 355 0
CTCF G2GSE9613 235579108 235579824 716 0
CTCF G2GSE9613 235581041 235581747 706 0
CTCF G2GSE9613 235585387 235585725 338 0
CTCF G2GSE9613 235589665 235589845 180 0
CTCF G2GSE9613 235592517 235592773 256 0
CTCF G2GSE9613 235602203 235602576 373 0
CTCF G2GSE9613 235615831 235616290 459 0
CTCF G2GSE9613 235618194 235618589 395 0
CTCF G2GSE9613 235620933 235621180 247 0
FOXA1 MCF7GSE15244 235554411 235555335 924 0
FOXA1 MCF7GSE15244 235580973 235582668 1695 0
FOXA1 MCF7GSE15244 235600168 235601220 1052 0
FoxA1 MCF7MACSdata 235554920 235555109 189 0
H3ac HepG2E 235526373 235527289 916 0
H3ac HepG2E 235527686 235528783 1097 0
H3ac HepG2E 235554015 235555366 1351 0
H3ac HepG2E 235555700 235556865 1165 0
Myc hESGSE17917 235578982 235579304 322 0
NRSF JurkatGSE13047 235614953 235615252 299 0
NRSF mAbJurkat 235615610 235616105 495 0
NRSF-mono JurkatQuESTdata 235614952 235615251 299 0
P300 T30-glioblastomaGSE21026 235623819 235625133 1314 0
RARA MCF7GSE15244 235580973 235582704 1731 0
Sox2 hESGSE18292 235534239 235534475 236 0
TFAP2C MCF7GSE21234 235543766 235544358 592 0
TFAP2C MCF7GSE21234 235556289 235556665 376 0
TFAP2C MCF7GSE21234 235574122 235574618 496 0
TFAP2C MCF7GSE21234 235618634 235619123 489 0
hScc1 BcellGSE12603 235525632 235526048 416 0
hScc1 BcellGSE12603 235568891 235569231 340 0
hScc1 G2GSE9613 235525632 235526373 741 0
hScc1 G2GSE9613 235581076 235581747 671 0
p130 QuiescentGSE19898 235530827 235531153 326 0
p130 SenescentGSE19898 235530912 235531147 235 0
p130 shRbSenescentGSE19898 235584577 235584810 233 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-100 hsa-mir-100 11 20585341
hsa-miR-100* hsa-mir-100 11 20585341
hsa-miR-125b hsa-mir-125b-1 11 20435889
hsa-miR-125b hsa-mir-125b-2 21 20435889
hsa-miR-146a hsa-mir-146a 5 20585341
hsa-miR-146a* hsa-mir-146a 5 20585341
hsa-miR-155 hsa-mir-155 21 19021522
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 19021522
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 15766526
hsa-miR-16 hsa-mir-16-2 3 15766526
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-196a hsa-mir-196a-2 12 20585341
hsa-miR-196a* hsa-mir-196a-2 12 20585341
hsa-miR-219-1-3p hsa-mir-219-1 6 20585341
hsa-miR-219-5p hsa-mir-219-1 6 20585341
hsa-miR-221 hsa-mir-221 X 20435889
hsa-miR-221* hsa-mir-221 X 20435889
hsa-miR-26a hsa-mir-26a-1 3 20585341
hsa-miR-26a hsa-mir-26a-2 12 20585341
hsa-miR-26a-1* hsa-mir-26a-1 3 20585341
hsa-miR-29a hsa-mir-29a 7 19247375
hsa-miR-29a* hsa-mir-29a 7 19247375
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
hsa-miR-423-3p hsa-mir-423 17 20585341
hsa-miR-423-5p hsa-mir-423 17 20585341
hsa-miR-579 hsa-mir-579 5 20435889
hsa-miR-604 hsa-mir-604 10 20585341
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1004 Unknown pSILAC miR-155 SH3BP4 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000130147 n_a n_a n_a "squamous cell, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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