AutismKB 2.0

Annotation Detail for ALOX5


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Basic Information Top
Gene Symbol:ALOX5 ( 5-LO,5-LOX,5LPG,LOG5,MGC163204 )
Gene Full Name: arachidonate 5-lipoxygenase
Band: 10q11.21
Quick LinksEntrez ID:240; OMIM: 152390; Uniprot ID:LOX5_HUMAN; ENSEMBL ID: ENSG00000012779; HGNC ID: 435
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
272Phosphoserine; by MAPKAPK2.
524Phosphoserine; by PKA.
Location(AA) Modifications Resource
271Phosphoserine (MAPKAPK2;PKA)Phospho.ELM 6.0
272Phosphoserine (by MAPKAPK2).Swiss-Prot 53.0
523Phosphoserine (PKA
524Phosphoserine (by PKA).Swiss-Prot 53.0
Location(AA) Modification Resource
7O-linkedHMM predict
43Phosphotyrosine(Syk)HMM predict
43Phosphotyrosine(EGFR)HMM predict
95SulfotyrosineHMM predict
143Phosphotyrosine(SRC)HMM predict
272Phosphoserine(CK1)HMM predict
272Phosphoserine(PKG)HMM predict
296N-linkedHMM predict
426N-linkedHMM predict
469SulfotyrosineHMM predict
571Phosphothreonine(PKC)HMM predict
578O-linkedHMM predict
659ProlineHMM predict
664Phosphoserine(CDC2)HMM predict
669ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000698
  • Location:chr10 45189634-45261566
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 45169594 45170397 803 19639
Oct1 H2O2-HelaGSE14283 45170396 45170426 30 19224
Oct1 H2O2-HelaGSE14283 45176830 45176857 27 12791
Oct1 HelaGSE14283 45170390 45170425 35 19227
P300 T0-glioblastomaGSE21026 45169516 45170386 870 19684
P300 T30-glioblastomaGSE21026 45169496 45170597 1101 19588
TAF k562GSE8489 45183638 45184012 374 5810
hScc1 BcellGSE12603 45188789 45189224 435 628
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 45259139 45260226 1087 0
NRSF-mono JurkatQuESTdata 45239528 45239932 404 0
SRF k562GSE8489 45226885 45228148 1263 0
VDR GM10861-stimGSE22484 45233670 45237603 3933 0
hScc1 BcellGSE12603 45189591 45190236 645 0
hScc1 BcellGSE12603 45195369 45195635 266 0
hScc1 BcellGSE12603 45243053 45243663 610 0
hScc1 BcellGSE12603 45258060 45258387 327 0
hScc1 CdLSGSE12603 45189422 45190197 775 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-135a hsa-mir-135a-1 3 20194722
hsa-miR-135a hsa-mir-135a-2 12 20194722
hsa-miR-199a-5p hsa-mir-199a-1 19 20194722
hsa-miR-199a-5p hsa-mir-199a-2 1 20194722
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
3074 mRNA ALOX5 chr10 45189691 45261567 1546 EST chr10 45260021 45268575 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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