Annotation Detail for ALOX5AP

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Basic Information Top

Gene Symbol:	ALOX5AP ( FLAP )
Gene Full Name:	arachidonate 5-lipoxygenase-activating protein
Band:	13q12.3
Quick Links	Entrez ID:241; OMIM: 603700; Uniprot ID:AL5AP_HUMAN; ENSEMBL ID: ENSG00000132965; HGNC ID: 436
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:4 results

No data

Location(AA)	Modification	Resource
79	Phosphoserine(ATM)	HMM predict
146	Phosphotyrosine(EGFR)	HMM predict
146	Phosphotyrosine(INSR)	HMM predict
155	Phosphoserine(MAPK)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001629
Location:chr13 30207668-30236555
strand:+

Upstream the gene:3 results
Downstream the gene:0 results
Inside the gene:12 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
NRSF-mono	Jurkat	QuESTdata	30200043	30200256	213	7519
Oct1	Hela	GSE14283	30203858	30203885	27	3797
P300	T30-glioblastoma	GSE21026	30190807	30191900	1093	16315

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
ER	MCF7	GSE19013	30214980	30216234	1254	0
FOXA1	MCF7	GSE15244	30215618	30216856	1238	0
Fos	K562	GSE19551	30212114	30212607	493	0
FoxA1	MCF7	MACSdata	30215818	30216009	191	0
Oct1	Hela	GSE14283	30224624	30224650	26	0
P300	T30-glioblastoma	GSE21026	30214999	30217116	2117	0
RARA	MCF7	GSE15244	30215316	30217143	1827	0
RARA	MCF7	GSE15244	30227110	30227419	309	0
RARG	MCF7	GSE15244	30215123	30217143	2020	0
RARG	MCF7	GSE15244	30227893	30228638	745	0
TFAP2C	MCF7	GSE21234	30215158	30216143	985	0
hScc1	CdLS	GSE12603	30216416	30216822	406	0

Validated miRNA targets

miR Walk:4 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-135a	hsa-mir-135a-1	3	20194722
hsa-miR-135a	hsa-mir-135a-2	12	20194722
hsa-miR-199a-5p	hsa-mir-199a-1	19	20194722
hsa-miR-199a-5p	hsa-mir-199a-2	1	20194722

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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