AutismKB 2.0

Annotation Detail for FRK


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Basic Information Top
Gene Symbol:FRK ( GTK,PTK5,RAK )
Gene Full Name: fyn-related kinase
Band: 6q22.1
Quick LinksEntrez ID:2444; OMIM: 606573; Uniprot ID:FRK_HUMAN; ENSEMBL ID: ENSG00000111816; HGNC ID: 3955
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
37Phosphoserine.
46Phosphotyrosine.
62Phosphoserine.
387Phosphotyrosine; by autocatalysis (By
497Phosphotyrosine.
Location(AA) Modifications Resource
387Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
497Phosphotyrosine.Swiss-Prot 53.0
497PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
37Phosphoserine(MAPK)HMM predict
135N-linkedHMM predict
147Phosphoserine(ATM)HMM predict
254N-linkedHMM predict
255N-linkedHMM predict
263Phosphothreonine(PKC)HMM predict
293Phosphotyrosine(Jak)HMM predict
303Phosphotyrosine(EGFR)HMM predict
303Phosphotyrosine(Jak)HMM predict
320N-linkedHMM predict
350Phosphotyrosine(INSR)HMM predict
368Phosphotyrosine(Jak)HMM predict
368Phosphotyrosine(Syk)HMM predict
387Phosphotyrosine(EGFR)HMM predict
490Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002031
  • Location:chr6 116369386-116488613
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 116501895 116502373 478 13521
ER MCF7GSE19013 116498833 116499826 993 10716
ER MCF7GSE19013 116501646 116502283 637 13351
FOXA1 MCF7GSE15244 116498911 116499348 437 10516
Fos K562GSE19551 116501850 116502380 530 13502
P300 T30-glioblastomaGSE21026 116501719 116502374 655 13433
SRF HelaGSE8489 116494430 116494752 322 5978
TFAP2C MCF7GSE21234 116501748 116502248 500 13385
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 116427901 116428449 548 0
CTCF HelaGSE12889 116438735 116438914 179 0
CTCF G2GSE9613 116438672 116439008 336 0
CTCF G2GSE9613 116458016 116458170 154 0
ER Fulvestrant-MCF7GSE14664 116454307 116454350 43 0
Fos K562GSE19551 116475326 116475701 375 0
FoxA1 MCF7MACSdata 116452968 116453284 316 0
H3ac HepG2E 116445644 116446141 497 0
H3ac HepG2E 116485071 116485713 642 0
H3ac HepG2E 116486097 116486444 347 0
H3ac HepG2E 116486804 116489589 2785 0
Jun K562GSE19551 116475470 116475730 260 0
Oct1 H2O2-HelaGSE14283 116454321 116454353 32 0
Oct1 HelaGSE14283 116423085 116423127 42 0
Oct1 HelaGSE14283 116435730 116435764 34 0
hScc1 CdLSGSE12603 116438485 116439045 560 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018