AutismKB 2.0

Annotation Detail for FYB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FYB ( ADAP,PRO0823,SLAP-130 )
Gene Full Name: FYN binding protein
Band: 5p13.1
Quick LinksEntrez ID:2533; OMIM: 602731; Uniprot ID:FYB_HUMAN; ENSEMBL ID: ENSG00000082074; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
3N6-acetyllysine.
28Phosphoserine (By similarity).
46Phosphoserine.
149N6-acetyllysine.
158Phosphothreonine.
265N6-acetyllysine.
425N6-acetyllysine.
457Phosphoserine.
465SH2-binding (Potential).
505Nuclear localization signal (Potential).
571Phosphotyrosine.
573Phosphoserine.
598SH2-binding; to LCP2.
628SH2-binding; to FYN.
651Phosphotyrosine.
700Nuclear localization signal (Potential).
711Phosphothreonine.
Location(AA) Modifications Resource
28Phosphoserine (By similarity).Swiss-Prot 53.0
571PhosphotyrosinePhospho.ELM 6.0
595Phosphotyrosine (Fyn)Phospho.ELM 6.0
651Phosphotyrosine (Fyn)Phospho.ELM 6.0
Location(AA) Modification Resource
9N-linkedHMM predict
44N-linkedHMM predict
46Phosphoserine(ATM)HMM predict
59Phosphoserine(CDC2)HMM predict
99Phosphothreonine(PKC)HMM predict
100O-linkedHMM predict
155O-linkedHMM predict
158Phosphothreonine(CDK)HMM predict
158Phosphothreonine(MAPK)HMM predict
162Phosphoserine(CK2)HMM predict
184Phosphoserine(ATM)HMM predict
218N-linkedHMM predict
221Phosphoserine(CK1)HMM predict
222O-linkedHMM predict
225Phosphoserine(CDC2)HMM predict
308Phosphothreonine(MAPK)HMM predict
341Phosphothreonine(MAPK)HMM predict
378N-linkedHMM predict
380O-linkedHMM predict
386O-linkedHMM predict
389O-linkedHMM predict
390O-linkedHMM predict
390O-linkedHMM predict
391O-linkedHMM predict
391O-linkedHMM predict
398O-linkedHMM predict
398O-linkedHMM predict
402Phosphoserine(ATM)HMM predict
402O-linkedHMM predict
409O-linkedHMM predict
412Phosphoserine(ATM)HMM predict
412O-linkedHMM predict
418O-linkedHMM predict
457Phosphoserine(CK2)HMM predict
457Phosphoserine(CK1)HMM predict
462SulfotyrosineHMM predict
462Phosphotyrosine(INSR)HMM predict
462PhosphotyrosineHMM predict
462Phosphotyrosine(Syk)HMM predict
462Phosphotyrosine(EGFR)HMM predict
462Phosphotyrosine(SRC)HMM predict
561Phosphotyrosine(Jak)HMM predict
595Phosphotyrosine(Syk)HMM predict
595SulfotyrosineHMM predict
605Phosphoserine(CK1)HMM predict
606Phosphoserine(CK1)HMM predict
608Phosphoserine(ATM)HMM predict
608Phosphoserine(IKK)HMM predict
625Phosphotyrosine(EGFR)HMM predict
625Phosphotyrosine(Syk)HMM predict
625Phosphotyrosine(INSR)HMM predict
625SulfotyrosineHMM predict
651Phosphotyrosine(Syk)HMM predict
651PhosphotyrosineHMM predict
667Phosphoserine(ATM)HMM predict
667Phosphoserine(IKK)HMM predict
714O-linkedHMM predict
715O-linkedHMM predict
716Phosphoserine(IKK)HMM predict
755Phosphotyrosine(Abl)HMM predict
755Phosphotyrosine(SRC)HMM predict
771Phosphotyrosine(Syk)HMM predict
771SulfotyrosineHMM predict
771Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001465
  • Location:chr5 39141114-39255423
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TFAP2C MCF7GSE21234 39255223 39255712 489 44
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 39136424 39137347 923 4229
CBP T30-glioblastomaGSE21026 39136360 39137430 1070 4220
P300 T0-glioblastomaGSE21026 39136364 39137326 962 4270
P300 T30-glioblastomaGSE21026 39136301 39137465 1164 4232
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 39184865 39185106 241 0
CTCF CD4SISSRdata 39184865 39185106 241 0
CTCF G2GSE9613 39173642 39173993 351 0
CTCF G2GSE9613 39184911 39185683 772 0
CTCF G2GSE9613 39251241 39251572 331 0
CTCF G2GSE9613 39253580 39254249 669 0
Fos K562GSE19551 39200617 39201194 577 0
Oct1 HelaGSE14283 39165960 39166004 44 0
STAT1 HeLaGSE12783 39173255 39175287 2032 0
TAF HelaGSE8489 39188009 39188673 664 0
hScc1 BcellGSE12603 39253580 39254050 470 0
hScc1 CdLSGSE12603 39253580 39254285 705 0
hScc1 G2GSE9613 39184693 39185683 990 0
hScc1 G2GSE9613 39253580 39254285 705 0
p130 SenescentGSE19898 39212644 39212769 125 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved