AutismKB 2.0

Annotation Detail for FYN


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Basic Information Top
Gene Symbol:FYN ( MGC45350,SLK,SYN )
Gene Full Name: FYN oncogene related to SRC, FGR, YES
Band: 6q21
Quick LinksEntrez ID:2534; OMIM: 137025; Uniprot ID:FYN_HUMAN; ENSEMBL ID: ENSG00000010810; HGNC ID: 4037
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
12Phosphothreonine; by PKC (By similarity).
15Phosphothreonine.
21Phosphoserine.
25Phosphoserine.
185Phosphotyrosine (By similarity).
213Phosphotyrosine.
214Phosphotyrosine.
254Phosphothreonine (By similarity).
257Phosphoserine.
420Phosphotyrosine; by autocatalysis.
440Phosphotyrosine.
512Phosphothreonine.
531Phosphotyrosine.
Location(AA) Modifications Resource
2N-myristoyl glycine.Swiss-Prot 53.0
3S-palmitoyl cysteine (By similarity).Swiss-Prot 53.0
6S-palmitoyl cysteine (By similarity).Swiss-Prot 53.0
11PhosphothreoninePhospho.ELM 6.0
12Phosphothreonine (by PKC) (Bysimilarity).Swiss-Prot 53.0
21Phosphoserine.Swiss-Prot 53.0
27Phosphotyrosine (Fyn;PDGFR be)Phospho.ELM 6.0
29Phosphotyrosine (Fyn)Phospho.ELM 6.0
38Phosphotyrosine (Fyn)Phospho.ELM 6.0
213PhosphotyrosinePhospho.ELM 6.0
419Phosphotyrosine (Fes;Fyn)Phospho.ELM 6.0
420Phosphotyrosine; by autocatalysis.Swiss-Prot 53.0
530Phosphotyrosine (Csk)Phospho.ELM 6.0
531Phosphotyrosine; negative regulation.Swiss-Prot 53.0
Location(AA) Modification Resource
21Phosphoserine(IKK)HMM predict
21Phosphoserine(CK1)HMM predict
35Phosphothreonine(MAPK)HMM predict
45O-linkedHMM predict
68N-linkedHMM predict
97Phosphothreonine(CK2)HMM predict
113N-linkedHMM predict
126Phosphothreonine(PKC)HMM predict
132Phosphotyrosine(Jak)HMM predict
132Phosphotyrosine(INSR)HMM predict
132Phosphotyrosine(EGFR)HMM predict
300Phosphothreonine(PKC)HMM predict
310Phosphoserine(CK2)HMM predict
330Phosphotyrosine(Jak)HMM predict
339Phosphotyrosine(Jak)HMM predict
339Phosphotyrosine(EGFR)HMM predict
339Phosphotyrosine(SRC)HMM predict
339Phosphotyrosine(INSR)HMM predict
339SulfotyrosineHMM predict
420Phosphotyrosine(INSR)HMM predict
420Phosphotyrosine(Syk)HMM predict
420PhosphotyrosineHMM predict
531Phosphotyrosine(SRC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002037
  • Location:chr6 112089179-112301319
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 112301059 112301791 732 106
KLF4 hESGSE17917 112301213 112301463 250 19
Rb QuiescentGSE19898 112301345 112301689 344 198
p130 SenescentGSE19898 112301261 112301629 368 126
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 112255865 112256097 232 0
CTCF G2GSE9613 112270023 112270308 285 0
CTCF G2GSE9613 112277209 112277533 324 0
CTCF G2GSE9613 112278528 112278709 181 0
Fos K562GSE19551 112196213 112196685 472 0
Gata1 K562GSE18868 112271309 112272038 729 0
Gata2 K562GSE18868 112271313 112271940 627 0
H3K27me3 colorectalcancer 112298977 112300393 1416 0
KLF4 hESGSE17917 112199703 112199874 171 0
Oct1 H2O2-HelaGSE14283 112237551 112237597 46 0
Oct1 HelaGSE14283 112199962 112200033 71 0
Oct1 HelaGSE14283 112237552 112237582 30 0
STAT1 HeLaGSE12783 112203844 112205253 1409 0
hScc1 BcellGSE12603 112193450 112193588 138 0
hScc1 BcellGSE12603 112301200 112301351 151 0
p130 shRbQuiescentGSE19898 112300020 112300552 532 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
23047 EST chr6 112122152 112122612 231 mRNA FYN chr6 112089177 112301320Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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