AutismKB 2.0

Annotation Detail for PLEKHG4


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Basic Information Top
Gene Symbol:PLEKHG4 ( ARHGEF44,DKFZp434I216,PRTPHN1,SCA4 )
Gene Full Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Band: 16q22.1
Quick LinksEntrez ID:25894; OMIM: 609526; Uniprot ID:PKHG4_HUMAN; ENSEMBL ID: ENSG00000196155; HGNC ID: 24501
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
64Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
14Phosphoserine(ATM)HMM predict
64Phosphoserine(CDK)HMM predict
86Phosphothreonine(PKC)HMM predict
134O-linkedHMM predict
139O-linkedHMM predict
225Phosphoserine(CK1)HMM predict
265Phosphoserine(CK1)HMM predict
268Phosphoserine(ATM)HMM predict
428Phosphotyrosine(Syk)HMM predict
460Phosphoserine(PKG)HMM predict
716O-linkedHMM predict
718O-linkedHMM predict
718Phosphothreonine(PKC)HMM predict
743Phosphothreonine(PKC)HMM predict
747Phosphotyrosine(EGFR)HMM predict
937Phosphothreonine(PKC)HMM predict
984S-palmitoylHMM predict
985S-palmitoylHMM predict
1057Phosphoserine(CK2)HMM predict
1080Phosphoserine(PKG)HMM predict
1117Phosphotyrosine(INSR)HMM predict
1159O-linkedHMM predict
1160Phosphoserine(ATM)HMM predict
1164Phosphoserine(IKK)HMM predict
1168O-linkedHMM predict
1173O-linkedHMM predict
1175S-farnesylHMM predict
1183ArginineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015432
  • Location:chr16 65868913-65880882
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
p130 SenescentGSE19898 65868693 65868979 286 78
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
P300 T30-glioblastomaGSE21026 65887243 65888765 1522 7122
TFAP2C MCF7GSE21234 65881059 65881440 381 367
p130 SenescentGSE19898 65887622 65887933 311 6895
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 65870708 65870969 261 0
CTCF CD4SISSRdata 65870708 65870969 261 0
CTCF G2GSE9613 65870330 65871338 1008 0
CTCF G2GSE9613 65879169 65879393 224 0
ETS1 JurkatGSE17954 65870374 65871295 921 0
P300 T30-glioblastomaGSE21026 65868228 65869871 1643 0
Rb shRbQuiescentGSE19898 65875096 65875326 230 0
TFAP2C MCF7GSE21234 65875466 65876721 1255 0
hScc1 BcellGSE12603 65870476 65871235 759 0
hScc1 CdLSGSE12603 65870476 65871061 585 0
p130 shRbSenescentGSE19898 65869158 65869386 228 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
10127 mRNA PLEKHG4 chr16 65869665 65880879 46 mRNA KCTD19 chr16 65880833 65918127Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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