AutismKB 2.0

Annotation Detail for PTPN23


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Basic Information Top
Gene Symbol:PTPN23 ( DKFZp564F0923,HD-PTP,HDPTP,KIAA1471,PTP-TD14 )
Gene Full Name: protein tyrosine phosphatase, non-receptor type 23
Band: 3p21.31
Quick LinksEntrez ID:25930; OMIM: 606584; Uniprot ID:PTN23_HUMAN; ENSEMBL ID: ENSG00000076201; HGNC ID: 14406
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1123Phosphoserine.
1126Phosphoserine.
1131Phosphothreonine.
1133Phosphoserine.
Location(AA) Modifications Resource
1126Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
41Phosphotyrosine(Abl)HMM predict
136Phosphoserine(CK2)HMM predict
320Phosphotyrosine(EGFR)HMM predict
345N-linkedHMM predict
370Phosphoserine(CK1)HMM predict
373Phosphoserine(CK1)HMM predict
434Phosphothreonine(PKC)HMM predict
486O-linkedHMM predict
542Phosphothreonine(MAPK)HMM predict
546Phosphoserine(ATM)HMM predict
592Phosphothreonine(PKC)HMM predict
652N-linkedHMM predict
665Phosphotyrosine(Syk)HMM predict
665SulfotyrosineHMM predict
679Phosphotyrosine(EGFR)HMM predict
679Phosphotyrosine(Syk)HMM predict
695Phosphoserine(IKK)HMM predict
767Phosphothreonine(MAPK)HMM predict
774O-linkedHMM predict
774Phosphoserine(CDC2)HMM predict
778O-linkedHMM predict
779O-linkedHMM predict
780O-linkedHMM predict
788O-linkedHMM predict
796Phosphotyrosine(SRC)HMM predict
796Phosphotyrosine(Abl)HMM predict
797Phosphoserine(IKK)HMM predict
838Phosphoserine(CDK)HMM predict
862O-linkedHMM predict
886O-linkedHMM predict
893O-linkedHMM predict
900N-linkedHMM predict
902O-linkedHMM predict
902O-linkedHMM predict
920O-linkedHMM predict
920O-linkedHMM predict
939O-linkedHMM predict
964Phosphoserine(ATM)HMM predict
964O-linkedHMM predict
1038Phosphoserine(CDC2)HMM predict
1038O-linkedHMM predict
1056O-linkedHMM predict
1073O-linkedHMM predict
1074O-linkedHMM predict
1074O-linkedHMM predict
1078Phosphoserine(IKK)HMM predict
1079Phosphothreonine(MAPK)HMM predict
1081O-linkedHMM predict
1081Phosphoserine(MAPK)HMM predict
1087O-linkedHMM predict
1087Phosphoserine(CDC2)HMM predict
1091Phosphoserine(CDK)HMM predict
1091Phosphoserine(ATM)HMM predict
1091Phosphoserine(CDC2)HMM predict
1091O-linkedHMM predict
1091PhosphoserineHMM predict
1122Phosphoserine(CK1)HMM predict
1123Phosphoserine(CDK)HMM predict
1123Phosphoserine(CDC2)HMM predict
1123Phosphoserine(MAPK)HMM predict
1126Phosphoserine(ATM)HMM predict
1165Phosphotyrosine(Syk)HMM predict
1165Phosphotyrosine(INSR)HMM predict
1218Phosphoserine(PKA)HMM predict
1243Phosphotyrosine(EGFR)HMM predict
1243Phosphotyrosine(INSR)HMM predict
1283Phosphoserine(PKG)HMM predict
1321Phosphoserine(CDC2)HMM predict
1325Phosphoserine(CK1)HMM predict
1363Phosphoserine(CDC2)HMM predict
1475Phosphoserine(ATM)HMM predict
1506Phosphoserine(PKG)HMM predict
1533O-linkedHMM predict
1538O-linkedHMM predict
1538O-linkedHMM predict
1542O-linkedHMM predict
1544O-linkedHMM predict
1544Phosphoserine(ATM)HMM predict
1550Phosphoserine(CDC2)HMM predict
1569O-linkedHMM predict
1570Phosphoserine(IKK)HMM predict
1570O-linkedHMM predict
1570Phosphoserine(ATM)HMM predict
1584Phosphothreonine(MAPK)HMM predict
1589Phosphoserine(CK1)HMM predict
1617Phosphothreonine(PKA)HMM predict
1620Phosphoserine(PKA)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015466
  • Location:chr3 47397494-47429934
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 47387704 47387895 191 9695
CTCF CD4SISSRdata 47387704 47387895 191 9695
CTCF JurkatGSE12889 47387637 47387926 289 9713
CTCF G2GSE9613 47386681 47386971 290 10669
CTCF G2GSE9613 47387408 47388082 674 9750
CTCF G2GSE9613 47392023 47392233 210 5367
CTCF G2GSE9613 47393586 47393918 332 3743
CTCF G2GSE9613 47396894 47397182 288 457
ETS1 JurkatGSE17954 47396657 47398326 1669 3
H3K4me3 colorectalcancer 47396180 47396522 342 1144
H3ac HepG2E 47396180 47397182 1002 814
PHF8 293TGSE20725 47396638 47398272 1634 40
PHF8 HeLaGSE20725 47396717 47398222 1505 25
TAF k562GSE8489 47396180 47397262 1082 774
TFAP2C MCF7GSE21234 47397046 47397517 471 213
VDR GM10855-stimGSE22484 47396080 47398514 2434 198
VDR GM10861-stimGSE22484 47395171 47398636 3465 591
hScc1 BcellGSE12603 47387408 47388049 641 9766
hScc1 CdLSGSE12603 47387335 47388049 714 9803
hScc1 G2GSE9613 47387372 47388049 677 9784
p130 shRbQuiescentGSE19898 47396626 47397408 782 478
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 47397432 47398166 734 0
CTCF G2GSE9613 47411393 47411754 361 0
CTCF G2GSE9613 47421549 47421790 241 0
CTCF G2GSE9613 47423531 47423704 173 0
CTCF G2GSE9613 47424912 47425157 245 0
CTCF G2GSE9613 47426116 47427821 1705 0
CTCF G2GSE9613 47429353 47429618 265 0
FOXA1 MCF7GSE15244 47398033 47398523 490 0
H3K4me3 colorectalcancer 47398166 47398766 600 0
H3ac HepG2E 47398238 47398766 528 0
H3ac HepG2E 47399495 47400652 1157 0
Oct1 H2O2-HelaGSE14283 47403125 47403164 39 0
Oct1 HelaGSE14283 47403127 47403163 36 0
Oct1 HelaGSE14283 47418515 47418563 48 0
PHF8 Hs68minusFBSGSE20725 47397388 47398343 955 0
PHF8 Hs68plusFBSGSE20725 47396532 47398477 1945 0
RARG MCF7GSE15244 47398095 47398559 464 0
hScc1 BcellGSE12603 47397644 47398166 522 0
hScc1 BcellGSE12603 47425979 47427479 1500 0
hScc1 G2GSE9613 47426258 47426997 739 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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