Annotation Detail for GARS

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	GARS ( CMT2D,DSMAV,GlyRS,HMN5,SMAD1 )
Gene Full Name:	glycyl-tRNA synthetase
Band:	7p14.3
Quick Links	Entrez ID:2617; OMIM: 600287; Uniprot ID:SYG_HUMAN; ENSEMBL ID: ENSG00000106105; HGNC ID: 4162
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

Top

PTM Sites from Uniprot:4 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:14 results

Location(AA)	Modification
204	N6-acetyllysine.
219	N6-acetyllysine.
453	Phosphotyrosine (By similarity).
501	N6-acetyllysine.

Location(AA)	Modification	Resource
35	Phosphoserine(PKA)	HMM predict
37	Phosphoserine(IKK)	HMM predict
45	O-linked	HMM predict
184	Phosphothreonine(MAPK)	HMM predict
273	Phosphoserine(ATM)	HMM predict
402	N-linked	HMM predict
403	N-linked	HMM predict
423	Phosphoserine(CDC2)	HMM predict
453	Phosphotyrosine(SRC)	HMM predict
476	Phosphothreonine(PKC)	HMM predict
622	Phosphoserine(ATM)	HMM predict
678	N-linked	HMM predict
713	N-linked	HMM predict
723	Phosphotyrosine(EGFR)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_002047
Location:chr7 30600705-30640170
strand:+

Upstream the gene:6 results
Downstream the gene:0 results
Inside the gene:24 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3ac	HepG2	E	30600163	30600887	724	181
Oct1	Hela	GSE14283	30581113	30581140	27	19579
Oct1	Hela	GSE14283	30581178	30581217	39	19508
Oct1	Hela	GSE14283	30598729	30598767	38	1958
p130	Quiescent	GSE19898	30600291	30600937	646	92
p130	shRbQuiescent	GSE19898	30600047	30600974	927	195

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	30600887	30601390	503
ER	E2-MCF7	GSE14664	30607949	30607985	36
ER	E2-MCF7	GSE14664	30608020	30608052	32
ER	E2-MCF7	GSE14664	30609842	30609886	44
ER	E2-MCF7	GSE14664	30611915	30611948	33
ETS1	Jurkat	GSE17954	30600019	30601585	1566
H3K4me3	colorectal	cancer	30601562	30602378	816
H3ac	HepG2	E	30601210	30602642	1432
Myc	hES	GSE17917	30600731	30601273	542
NRSF	mAb	Jurkat	30601602	30602342	740
Nanog	ES	GSE20650	30600715	30601138	423
Oct1	Hela	GSE14283	30610198	30610263	65
Oct1	Hela	GSE14283	30611915	30611945	30
Oct1	Hela	GSE14283	30611994	30612039	45
P300	T30-glioblastoma	GSE21026	30599830	30603515	3685
PHF8	HeLa	GSE20725	30600257	30601728	1471
TAF	Hela	GSE8489	30601519	30602378	859
TAF	k562	GSE8489	30601210	30603096	1886
TAFII	hES	GSE17917	30600799	30601391	592
VDR	GM10855-stim	GSE22484	30636824	30638005	1181
VDR	GM10861-stim	GSE22484	30636585	30638117	1532
p130	Senescent	GSE19898	30600551	30601153	602
p130	shRbQuiescent	GSE19898	30601135	30601603	468
p130	shRbSenescent	GSE19898	30600407	30601720	1313

Validated miRNA targets

Top

miR Walk:70 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	20427544
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155	hsa-mir-155	21	20427544
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	20427544
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	20427544
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-195	hsa-mir-195	17	20845893
hsa-miR-195	hsa-mir-195	17	20845893
hsa-miR-195*	hsa-mir-195	17	20845893
hsa-miR-195*	hsa-mir-195	17	20845893
hsa-miR-199a-3p	hsa-mir-199a-1	19	19251704
hsa-miR-199a-3p	hsa-mir-199a-2	1	19251704
hsa-miR-199a-3p	hsa-mir-199a-1	19	19251704
hsa-miR-199a-3p	hsa-mir-199a-2	1	19251704
hsa-miR-206	hsa-mir-206	6	19341710
hsa-miR-206	hsa-mir-206	6	19341710
hsa-miR-26a	hsa-mir-26a-1	3	20845893
hsa-miR-26a	hsa-mir-26a-2	12	20845893
hsa-miR-26a	hsa-mir-26a-1	3	18197755
hsa-miR-26a	hsa-mir-26a-2	12	18197755
hsa-miR-26a	hsa-mir-26a-1	3	17922609
hsa-miR-26a	hsa-mir-26a-2	12	17922609
hsa-miR-26a	hsa-mir-26a-1	3	20845893
hsa-miR-26a	hsa-mir-26a-2	12	20845893
hsa-miR-26a	hsa-mir-26a-1	3	18197755
hsa-miR-26a	hsa-mir-26a-2	12	18197755
hsa-miR-26a	hsa-mir-26a-1	3	17922609
hsa-miR-26a	hsa-mir-26a-2	12	17922609
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	20845893
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b	hsa-mir-30b	8	20845893
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	20845893
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	20845893
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

Cis-Nats regulation

Top

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for GARS

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics