Annotation Detail for GCH1
Basic Information Top
| Gene Symbol: | GCH1 ( DYT14,DYT5,DYT5a,GCH,GTP-CH-1,GTPCH1,HPABH4B ) |
|---|---|
| Gene Full Name: | GTP cyclohydrolase 1 |
| Band: | 14q22.2 |
| Quick Links | Entrez ID:2643; OMIM: 600225; Uniprot ID:GCH1_HUMAN; ENSEMBL ID: ENSG00000131979; HGNC ID: 4193 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 60 | Phosphoserine. | |
| 81 | Phosphoserine. | |
| Location(AA) | Modifications | Resource |
|---|
| Location(AA) | Modification | Resource |
|---|---|---|
| 33 | O-linked | HMM predict |
| 60 | Phosphoserine(IKK) | HMM predict |
| 60 | Phosphoserine | HMM predict |
| 80 | Phosphoserine(CK1) | HMM predict |
| 94 | Phosphothreonine(CDC2) | HMM predict |
- RefSeq ID: NM_001024071
- Location:chr14 54378475-54439291
- strand:-
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CTCF | G2 | GSE9613 | 54439017 | 54439766 | 749 | 100 |
| ER | E2-MCF7 | GSE14664 | 54454406 | 54454512 | 106 | 15168 |
| Oct1 | H2O2-Hela | GSE14283 | 54444680 | 54444708 | 28 | 5403 |
| Oct1 | H2O2-Hela | GSE14283 | 54456648 | 54456680 | 32 | 17373 |
| Oct1 | Hela | GSE14283 | 54456643 | 54456732 | 89 | 17396 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| FOXA1 | MCF7 | GSE15244 | 54376169 | 54376772 | 603 | 2005 |
| Rb | Growing | GSE19898 | 54376223 | 54376372 | 149 | 2178 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CTCF | CD4 | GSE12889 | 54429662 | 54429921 | 259 | 0 |
| CTCF | CD4 | SISSRdata | 54429662 | 54429921 | 259 | 0 |
| CTCF | Hela | GSE12889 | 54429748 | 54429922 | 174 | 0 |
| CTCF | G2 | GSE9613 | 54438419 | 54438693 | 274 | 0 |
| H3ac | HepG2 | E | 54437235 | 54438243 | 1008 | 0 |
| Myc | hES | GSE17917 | 54395595 | 54395867 | 272 | 0 |
| Nanog | ES | GSE20650 | 54390621 | 54391028 | 407 | 0 |
| Nanog | ES | GSE20650 | 54414138 | 54414571 | 433 | 0 |
| Nanog | hES | GSE18292 | 54399362 | 54399588 | 226 | 0 |
| Pol2 | GM12878 | GSE19551 | 54438321 | 54439603 | 1282 | 0 |
| TFAP2C | MCF7 | GSE21234 | 54438614 | 54439001 | 387 | 0 |
| hScc1 | Bcell | GSE12603 | 54438310 | 54439282 | 972 | 0 |
| hScc1 | CdLS | GSE12603 | 54417692 | 54417918 | 226 | 0 |
| Micro RNA Name | Stem Loop Name | The chromosome that miRNA located | Publication |
|---|---|---|---|
| hsa-miR-1 | hsa-mir-1-2 | 18 | 15685193 |
| hsa-miR-1 | hsa-mir-1-1 | 20 | 15685193 |
| hsa-miR-124 | hsa-mir-124-1 | 8 | 15685193 |
| hsa-miR-124 | hsa-mir-124-2 | 8 | 15685193 |
| hsa-miR-124 | hsa-mir-124-3 | 20 | 15685193 |
| hsa-miR-373 | hsa-mir-373 | 19 | 15685193 |
| hsa-miR-373* | hsa-mir-373 | 19 | 15685193 |
| ID in Tarbase | Data Type | Support Type | miRNA | Gene | Direct Support | Publication |
|---|---|---|---|---|---|---|
| 162 | Unknown | MicroArray | miR-1 | GCH1 | n_a | 15685193 |
| Ensembl | Protein Type | Differentially expressed in | Pathology or Event | Mis Regulation | Gene Expression | Tumour Involvement |
| ENSG00000131979 | "cardiac and skeletal muscles, cardiogenesis" | n_a | n_a | "lymphoblast, lymphocyte, leukocyte, muscle cell" | "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma" |
| Cluster ID | Plue Type | Plus Gene Name | Plus Chromosome | Plus Start | Plus End | Overlap Length | Minus Type | Minus Gene Name | Minus Chromosome | Minus Star | Minus End | Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7931 | HTC | GCH1 | chr14 | 54438773 | 54440268 | 491 | mRNA | GCH1 | chr14 | 54378484 | 54439279 | Sense/Antisense (SA) pairs |