AutismKB 2.0

Annotation Detail for LATS2


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Basic Information Top
Gene Symbol:LATS2 ( FLJ13161,KPM )
Gene Full Name: LATS, large tumor suppressor, homolog 2 (Drosophila)
Band: 13q12.11
Quick LinksEntrez ID:26524; OMIM: 604861; Uniprot ID:LATS2_HUMAN; ENSEMBL ID: ENSG00000150457; HGNC ID: 6515
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
83Phosphoserine; by STK6.
279Phosphothreonine.
380Phosphoserine.
518PPxY motif.
Location(AA) Modifications Resource
83Phosphoserine (by STK6).Swiss-Prot 53.0
83Phosphoserine (Aurora A)Phospho.ELM 6.0
Location(AA) Modification Resource
9O-linkedHMM predict
10O-linkedHMM predict
89N-linkedHMM predict
94O-linkedHMM predict
141Phosphotyrosine(Syk)HMM predict
172Phosphoserine(PKA)HMM predict
172Phosphoserine(PKC)HMM predict
191Phosphotyrosine(INSR)HMM predict
191Phosphotyrosine(Abl)HMM predict
191Phosphotyrosine(Syk)HMM predict
274Phosphoserine(PKB)HMM predict
274Phosphoserine(PKA)HMM predict
274Phosphoserine(PKC)HMM predict
277Phosphoserine(IKK)HMM predict
279Phosphothreonine(MAPK)HMM predict
279PhosphothreonineHMM predict
279O-linkedHMM predict
333O-linkedHMM predict
342Phosphoserine(ATM)HMM predict
342Phosphoserine(IKK)HMM predict
349Phosphothreonine(CDK)HMM predict
349Phosphothreonine(MAPK)HMM predict
366Phosphoserine(CK1)HMM predict
380Phosphoserine(PKG)HMM predict
408Phosphoserine(PKB)HMM predict
408Phosphoserine(IKK)HMM predict
425O-linkedHMM predict
431O-linkedHMM predict
461O-linkedHMM predict
576Phosphoserine(CDK)HMM predict
576Phosphoserine(CDC2)HMM predict
584Phosphoserine(PKG)HMM predict
592PhosphoserineHMM predict
596Phosphoserine(PKG)HMM predict
698Phosphothreonine(PKC)HMM predict
742Phosphotyrosine(INSR)HMM predict
839Phosphoserine(ATM)HMM predict
856Phosphothreonine(PKC)HMM predict
879Phosphotyrosine(INSR)HMM predict
917Phosphothreonine(MAPK)HMM predict
941Phosphoserine(CDC2)HMM predict
994O-linkedHMM predict
1018Phosphoserine(CK1)HMM predict
1027Phosphoserine(CDC2)HMM predict
1064Phosphoserine(IKK)HMM predict
1064Phosphoserine(ATM)HMM predict
1068Phosphoserine(CK2)HMM predict
1069Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014572
  • Location:chr13 20446578-20533653
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 20533183 20534161 978 19
CBP T30-glioblastomaGSE21026 20541583 20542480 897 8378
CTCF G2GSE9613 20547608 20547943 335 14122
CTCF G2GSE9613 20548438 20548698 260 14915
P300 T30-glioblastomaGSE21026 20541379 20542558 1179 8315
RARA MCF7GSE15244 20543133 20543498 365 9662
RARG MCF7GSE15244 20543133 20543813 680 9820
STAT1 HeLaGSE12783 20541399 20542394 995 8243
USF1 HepG2E 20533891 20534122 231 353
USF1 HepG2E 20534466 20535206 740 1183
hScc1 BcellGSE12603 20547868 20548007 139 14284
p130 shRbSenescentGSE19898 20546905 20547071 166 13335
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
RARA MCF7GSE15244 20433312 20434379 1067 12733
RARG MCF7GSE15244 20433312 20434379 1067 12733
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 20460798 20461493 695 0
CTCF G2GSE9613 20463553 20463740 187 0
CTCF G2GSE9613 20470650 20471499 849 0
CTCF G2GSE9613 20478836 20479052 216 0
CTCF G2GSE9613 20480203 20480449 246 0
CTCF G2GSE9613 20490473 20490775 302 0
CTCF G2GSE9613 20507789 20508006 217 0
CTCF G2GSE9613 20512554 20512743 189 0
CTCF G2GSE9613 20532384 20533934 1550 0
ER Fulvestrant-MCF7GSE14664 20520045 20520156 111 0
FOXA1 MCF7GSE15244 20486539 20487384 845 0
Fos K562GSE19551 20482716 20483178 462 0
Oct1 HelaGSE14283 20473016 20473052 36 0
P300 T30-glioblastomaGSE21026 20532684 20534273 1589 0
PHF8 HeLaGSE20725 20532433 20534107 1674 0
RARA MCF7GSE15244 20486672 20487199 527 0
RARG MCF7GSE15244 20453133 20453412 279 0
RARG MCF7GSE15244 20486672 20487163 491 0
RNAII Tamoxifen-MCF7GSE14664 20520001 20520160 159 0
TFAP2C MCF7GSE21234 20490341 20490882 541 0
hScc1 BcellGSE12603 20506802 20506997 195 0
hScc1 BcellGSE12603 20532898 20533853 955 0
hScc1 CdLSGSE12603 20532517 20534122 1605 0
p130 SenescentGSE19898 20469758 20470033 275 0
p130 shRbQuiescentGSE19898 20469456 20470008 552 0
p63 keratinocytesGSE17611 20525172 20526076 904 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 18155131
hsa-miR-1 hsa-mir-1-1 20 18155131
hsa-miR-136 hsa-mir-136 14 20237410
hsa-miR-136* hsa-mir-136 14 20237410
hsa-miR-155 hsa-mir-155 21 21062812
hsa-miR-155* hsa-mir-155 21 21062812
hsa-miR-206 hsa-mir-206 6 18155131
hsa-miR-221 hsa-mir-221 X 18155131
hsa-miR-221* hsa-mir-221 X 18155131
hsa-miR-31 hsa-mir-31 9 20237410
hsa-miR-31* hsa-mir-31 9 20237410
hsa-miR-371-3p hsa-mir-371 19 17695719
hsa-miR-371-5p hsa-mir-371 19 17695719
hsa-miR-372 hsa-mir-372 19 19937137
hsa-miR-372 hsa-mir-372 19 17695719
hsa-miR-372 hsa-mir-372 19 16564011
hsa-miR-372 hsa-mir-372 19 18155131
hsa-miR-373 hsa-mir-373 19 19501585
hsa-miR-373 hsa-mir-373 19 17695719
hsa-miR-373 hsa-mir-373 19 16564011
hsa-miR-373* hsa-mir-373 19 19501585
hsa-miR-373* hsa-mir-373 19 17695719
hsa-miR-373* hsa-mir-373 19 16564011
hsa-miR-376a hsa-mir-376a-1 0 20237410
hsa-miR-376a hsa-mir-376a-2 0 20237410
hsa-miR-424 hsa-mir-424 X 21062812
hsa-miR-424* hsa-mir-424 X 21062812
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
618 mRNA repression TRUE miR-372 LATS2 in vitro reporter gene assay (Luciferase) 16564011
619 mRNA cleavage TRUE miR-372 LATS2 in vitro reporter gene assay (Luciferase) 16564011
686 mRNA repression TRUE miR-373 LATS2 in vitro reporter gene assay (Luciferase) 16564011
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000150457 myocytes / breast n_a n_a n_a n_a
ENSG00000150457 myocytes / breast n_a n_a n_a n_a
ENSG00000150457 n_a n_a n_a n_a n_a
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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