AutismKB 2.0

Annotation Detail for RPS6KC1


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Basic Information Top
Gene Symbol:RPS6KC1 ( RPK118,humS6PKh1 )
Gene Full Name: ribosomal protein S6 kinase, 52kDa, polypeptide 1
Band: 1q32.3
Quick LinksEntrez ID:26750; OMIM: NA; Uniprot ID:KS6C1_HUMAN; ENSEMBL ID: ENSG00000136643; HGNC ID: 10439
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
423Phosphoserine.
427Phosphoserine.
583Phosphoserine (By similarity).
640Phosphoserine (By similarity).
Location(AA) Modifications Resource
423Phosphoserine.Swiss-Prot 53.0
427Phosphoserine.Swiss-Prot 53.0
640Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
30Phosphotyrosine(Syk)HMM predict
131N-linkedHMM predict
144Phosphoserine(CK1)HMM predict
161Phosphoserine(CK2)HMM predict
188Phosphoserine(CDC2)HMM predict
196N-linkedHMM predict
214Phosphoserine(CK1)HMM predict
216Phosphothreonine(CK2)HMM predict
259Phosphotyrosine(EGFR)HMM predict
259Phosphotyrosine(INSR)HMM predict
259Phosphotyrosine(Syk)HMM predict
259Phosphotyrosine(SRC)HMM predict
259PhosphotyrosineHMM predict
259SulfotyrosineHMM predict
282Phosphoserine(CDC2)HMM predict
284Phosphothreonine(PKC)HMM predict
293Phosphothreonine(PKA)HMM predict
302Phosphoserine(IKK)HMM predict
305Phosphoserine(CK1)HMM predict
316Phosphoserine(ATM)HMM predict
332Phosphoserine(CDK)HMM predict
332Phosphoserine(CDC2)HMM predict
421N-linkedHMM predict
423Phosphoserine(CDC2)HMM predict
423PhosphoserineHMM predict
437Phosphothreonine(PKC)HMM predict
437Phosphothreonine(PKA)HMM predict
449Phosphoserine(ATM)HMM predict
449Phosphoserine(CDC2)HMM predict
461Phosphoserine(CK1)HMM predict
477Phosphothreonine(MAPK)HMM predict
477Phosphothreonine(CDK)HMM predict
480Phosphoserine(ATM)HMM predict
484Phosphoserine(IKK)HMM predict
484Phosphoserine(CK2)HMM predict
494Phosphoserine(ATM)HMM predict
502Phosphoserine(CK1)HMM predict
504Phosphoserine(CK2)HMM predict
560Phosphoserine(IKK)HMM predict
560Phosphoserine(CK1)HMM predict
583PhosphoserineHMM predict
583Phosphoserine(CDK)HMM predict
583Phosphoserine(CDC2)HMM predict
593Phosphoserine(IKK)HMM predict
644Phosphoserine(IKK)HMM predict
646N-linkedHMM predict
667Phosphoserine(ATM)HMM predict
753Phosphoserine(ATM)HMM predict
784Phosphoserine(IKK)HMM predict
795Phosphoserine(ATM)HMM predict
812N-linkedHMM predict
813N-linkedHMM predict
823Phosphoserine(MAPK)HMM predict
957Phosphoserine(IKK)HMM predict
1026Phosphoserine(CK1)HMM predict
1052SerineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_012424
  • Location:chr1 211291219-211513429
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
GABP k562GSE8489 211288854 211289753 899 1916
GABP k562GSE8489 211290092 211292160 2068 94
H3K4me3 colorectalcancer 211290092 211291165 1073 591
Rb QuiescentGSE19898 211290911 211291321 410 104
TAF k562GSE8489 211288854 211289753 899 1916
TAF k562GSE8489 211290092 211290908 816 720
p130 SenescentGSE19898 211290765 211291273 508 201
p130 shRbQuiescentGSE19898 211290662 211291303 641 237
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 211291307 211291454 147 0
CTCF G2GSE9613 211362623 211362873 250 0
CTCF G2GSE9613 211484734 211484945 211 0
Fos K562GSE19551 211500643 211501079 436 0
H3K4me3 colorectalcancer 211291805 211292160 355 0
H3ac HepG2E 211291537 211291987 450 0
Nanog ESGSE20650 211471793 211472456 663 0
Nanog hESGSE18292 211416407 211416839 432 0
Nanog hESGSE18292 211471739 211472488 749 0
Rb QuiescentGSE19898 211359861 211360001 140 0
TAF k562GSE8489 211291622 211292160 538 0
TAFII hESGSE17917 211291086 211291470 384 0
hScc1 BcellGSE12603 211484696 211484945 249 0
hScc1 CdLSGSE12603 211484585 211485123 538 0
p63 keratinocytesGSE17611 211294840 211295635 795 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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