AutismKB 2.0

Annotation Detail for AKAP8L


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Basic Information Top
Gene Symbol:AKAP8L ( DKFZp434L0650,HA95,HAP95,NAKAP,NAKAP95 )
Gene Full Name: A kinase (PRKA) anchor protein 8-like
Band: 19p13.12
Quick LinksEntrez ID:26993; OMIM: 609475; Uniprot ID:AKP8L_HUMAN; ENSEMBL ID: ENSG00000011243; HGNC ID: 29857
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
257N6-acetyllysine.
279Nuclear localization signal (Potential).
283Phosphoserine.
292Phosphothreonine.
294Phosphothreonine.
297Phosphoserine.
300Phosphoserine.
302Phosphoserine.
308Phosphothreonine.
364Nuclear localization signal (Potential).
552Phosphoserine.
Location(AA) Modifications Resource
283Phosphoserine.Swiss-Prot 53.0
283PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
17O-linkedHMM predict
18Phosphotyrosine(Syk)HMM predict
19Phosphoserine(CK1)HMM predict
29SulfotyrosineHMM predict
49SulfotyrosineHMM predict
55N-linkedHMM predict
58N-linkedHMM predict
59SulfotyrosineHMM predict
74Phosphoserine(CK2)HMM predict
79N-linkedHMM predict
80O-linkedHMM predict
81O-linkedHMM predict
83Phosphoserine(CK2)HMM predict
85Phosphoserine(IKK)HMM predict
122Phosphotyrosine(INSR)HMM predict
124PhosphoserineHMM predict
127PhosphoserineHMM predict
140Phosphotyrosine(INSR)HMM predict
146Phosphotyrosine(INSR)HMM predict
146PhosphotyrosineHMM predict
161Phosphotyrosine(SRC)HMM predict
171MethylarginineHMM predict
173N-linkedHMM predict
213Phosphoserine(IKK)HMM predict
237MethylarginineHMM predict
247MethylarginineHMM predict
283Phosphoserine(IKK)HMM predict
283Phosphoserine(CDC2)HMM predict
354Phosphothreonine(CK2)HMM predict
361Phosphothreonine(PKC)HMM predict
400Phosphotyrosine(Syk)HMM predict
438N-linkedHMM predict
552Phosphoserine(CDC2)HMM predict
601Phosphoserine(CDC2)HMM predict
601O-linkedHMM predict
601Phosphoserine(CDK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014371
  • Location:chr19 15351858-15390832
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 15390928 15391352 424 308
CTCF CD4SISSRdata 15390928 15391352 424 308
CTCF G2GSE9613 15405361 15405751 390 14724
ETS1 JurkatGSE17954 15403808 15405264 1456 13704
H3ac HepG2E 15403255 15404148 893 12869
Myc K562GSE19551 15404409 15404915 506 13830
NFkBII GM10847GSE19485 15404006 15405335 1329 13838
P300 T30-glioblastomaGSE21026 15404192 15405133 941 13830
PHF8 HeLaGSE20725 15403758 15405254 1496 13674
TFAP2C MCF7GSE21234 15409874 15410358 484 19284
VDR GM10861-UnstimGSE22484 15403966 15405537 1571 13919
hScc1 BcellGSE12603 15390362 15391467 1105 82
hScc1 BcellGSE12603 15402587 15403010 423 11966
hScc1 BcellGSE12603 15404474 15405064 590 13937
hScc1 CdLSGSE12603 15390660 15391648 988 322
p130 SenescentGSE19898 15404661 15404973 312 13985
p130 shRbQuiescentGSE19898 15404493 15405184 691 14006
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
VDR GM10861-stimGSE22484 15349629 15353940 4311 74
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 15373979 15374293 314 0
CTCF G2GSE9613 15375036 15375264 228 0
Fos K562GSE19551 15390045 15391428 1383 0
H3K4me3 colorectalcancer 15389409 15390390 981 0
H3ac HepG2E 15352551 15353765 1214 0
H3ac HepG2E 15389437 15390042 605 0
Myc hESGSE17917 15390625 15390902 277 0
P300 T30-glioblastomaGSE21026 15389815 15391687 1872 0
PHF8 HeLaGSE20725 15390106 15391335 1229 0
TFAP2C MCF7GSE21234 15351992 15352526 534 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
12823 HTC chr19 15350886 15352656 479 mRNA AKAP8L chr19 15351858 15390833Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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