AutismKB 2.0

Annotation Detail for CYFIP2


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Basic Information Top
Gene Symbol:CYFIP2 ( PIR121 )
Gene Full Name: cytoplasmic FMR1 interacting protein 2
Band: 5q33.3
Quick LinksEntrez ID:26999; OMIM: 606323; Uniprot ID:CYFP2_HUMAN; ENSEMBL ID: ENSG00000055163; HGNC ID: 13760
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
108Phosphotyrosine.
1062N6-acetyllysine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
79Phosphotyrosine(Syk)HMM predict
79Phosphotyrosine(Jak)HMM predict
79Phosphotyrosine(Abl)HMM predict
79Phosphotyrosine(INSR)HMM predict
188Phosphotyrosine(Syk)HMM predict
203Phosphoserine(IKK)HMM predict
256Phosphothreonine(MAPK)HMM predict
321Phosphothreonine(PKC)HMM predict
328N-linkedHMM predict
340Phosphoserine(CDC2)HMM predict
340Phosphoserine(ATM)HMM predict
379Phosphoserine(ATM)HMM predict
382Phosphoserine(CK2)HMM predict
386Phosphotyrosine(Syk)HMM predict
386Phosphotyrosine(EGFR)HMM predict
441N-linkedHMM predict
442Phosphotyrosine(INSR)HMM predict
442SulfotyrosineHMM predict
490Phosphothreonine(PKC)HMM predict
536O-linkedHMM predict
603Phosphothreonine(PKC)HMM predict
640S-palmitoylHMM predict
770Phosphotyrosine(Syk)HMM predict
793Phosphothreonine(PKC)HMM predict
797Phosphoserine(PKG)HMM predict
818Phosphoserine(CK1)HMM predict
855N-linkedHMM predict
882N-linkedHMM predict
886N-linkedHMM predict
991Phosphotyrosine(INSR)HMM predict
991Phosphotyrosine(Syk)HMM predict
1039Phosphoserine(ATM)HMM predict
1039Phosphoserine(CK2)HMM predict
1039Phosphoserine(CK1)HMM predict
1257O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001037332
  • Location:chr5 156625764-156755181
  • strand:+
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 156625407 156626588 1181 0
FoxA1 MCF7MACSdata 156627429 156627703 274 0
TFAP2C MCF7GSE21234 156627269 156628028 759 0
hScc1 BcellGSE12603 156625407 156626372 965 0
hScc1 CdLSGSE12603 156625379 156626340 961 0
p63 keratinocytesGSE17611 156627203 156627825 622 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 21252116
hsa-let-7a hsa-let-7a-2 11 21252116
hsa-let-7a hsa-let-7a-3 22 21252116
hsa-let-7a* hsa-let-7a-1 9 21252116
hsa-let-7a* hsa-let-7a-3 22 21252116
hsa-let-7b hsa-let-7b 22 21252116
hsa-let-7b* hsa-let-7b 22 21252116
hsa-let-7c hsa-let-7c 21 21252116
hsa-let-7c* hsa-let-7c 21 21252116
hsa-let-7d hsa-let-7d 9 21252116
hsa-let-7d* hsa-let-7d 9 21252116
hsa-let-7e hsa-let-7e 19 21252116
hsa-let-7e* hsa-let-7e 19 21252116
hsa-let-7f hsa-let-7f-1 9 21252116
hsa-let-7f hsa-let-7f-2 X 21252116
hsa-let-7f-1* hsa-let-7f-1 9 21252116
hsa-let-7f-2* hsa-let-7f-2 X 21252116
hsa-let-7g hsa-let-7g 3 21252116
hsa-let-7g* hsa-let-7g 3 21252116
hsa-let-7i hsa-let-7i 12 21252116
hsa-let-7i* hsa-let-7i 12 21252116
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
21733 HTC CYFIP2 chr5 156753561 156755170 51 mRNA ADAM19 chr5 156755119 156935361Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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