AutismKB 2.0

Annotation Detail for TNFRSF21


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Basic Information Top
Gene Symbol:TNFRSF21 ( BM-018,DR6,MGC31965 )
Gene Full Name: tumor necrosis factor receptor superfamily, member 21
Band: 6p12.3
Quick LinksEntrez ID:27242; OMIM: 605732; Uniprot ID:TNR21_HUMAN; ENSEMBL ID: ENSG00000146072; HGNC ID: 13469
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
82N-linked (GlcNAc...) (Potential).
141N-linked (GlcNAc...) (Potential).
252N-linked (GlcNAc...) (Potential).
257N-linked (GlcNAc...) (Potential).
278N-linked (GlcNAc...) (Potential).
289N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
82N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
141N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
252N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
257N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
278N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
289N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
7O-linkedHMM predict
8O-linkedHMM predict
9O-linkedHMM predict
22Phosphothreonine(PKA)HMM predict
38O-linkedHMM predict
53Phosphothreonine(PKC)HMM predict
82N-linkedHMM predict
141N-linkedHMM predict
216O-linkedHMM predict
218Phosphoserine(CK1)HMM predict
218O-linkedHMM predict
219Phosphoserine(IKK)HMM predict
219O-linkedHMM predict
220O-linkedHMM predict
221O-linkedHMM predict
222Phosphoserine(CDC2)HMM predict
222Phosphoserine(MAPK)HMM predict
222Phosphoserine(ATM)HMM predict
224Phosphoserine(CDC2)HMM predict
243O-linkedHMM predict
252N-linkedHMM predict
257N-linkedHMM predict
278N-linkedHMM predict
289N-linkedHMM predict
294N-linkedHMM predict
326Phosphothreonine(CDC2)HMM predict
376Phosphothreonine(PKC)HMM predict
399Phosphothreonine(MAPK)HMM predict
399Phosphothreonine(CDK)HMM predict
439N-linkedHMM predict
514Phosphoserine(MAPK)HMM predict
516Phosphoserine(CDK)HMM predict
516Phosphoserine(CDC2)HMM predict
519Phosphoserine(CDC2)HMM predict
521PhosphoserineHMM predict
521Phosphoserine(CDC2)HMM predict
525Phosphoserine(MAPK)HMM predict
537Phosphothreonine(PKC)HMM predict
562Phosphoserine(IKK)HMM predict
562Phosphoserine(CK1)HMM predict
563O-linkedHMM predict
565Phosphoserine(CK1)HMM predict
640Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014452
  • Location:chr6 47307227-47385638
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 47385643 47385868 225 117
CTCF CD4SISSRdata 47385643 47385868 225 117
CTCF HelaGSE12889 47385574 47385860 286 79
H3ac HepG2E 47385755 47385949 194 214
Myc K562GSE19551 47385411 47385949 538 42
Oct1 H2O2-HelaGSE14283 47392328 47392363 35 6707
Oct1 HelaGSE14283 47392327 47392367 40 6709
TFAP2C MCF7GSE21234 47385525 47385869 344 59
USF1 HepG2E 47385608 47385949 341 140
hScc1 CdLSGSE12603 47385332 47386212 880 134
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog ESGSE20650 47297221 47297734 513 9750
Nanog ESGSE20650 47304953 47305489 536 2007
Nanog hESGSE18292 47305064 47305433 369 1979
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 47351634 47351932 298 0
CTCF G2GSE9613 47384873 47385949 1076 0
ER E2-MCF7GSE14664 47362174 47362214 40 0
ER E2-MCF7GSE14664 47383741 47383774 33 0
Fos K562GSE19551 47317983 47319005 1022 0
H3K4me3 colorectalcancer 47382797 47383048 251 0
H3K4me3 colorectalcancer 47383385 47384015 630 0
H3ac HepG2E 47381359 47382306 947 0
H3ac HepG2E 47383385 47384181 796 0
H3ac HepG2E 47384583 47384909 326 0
KLF4 hESGSE17917 47312281 47312550 269 0
Myc K562GSE19551 47318166 47318636 470 0
Nanog hESGSE18292 47342110 47342570 460 0
Oct1 H2O2-HelaGSE14283 47315620 47315657 37 0
Oct1 HelaGSE14283 47314696 47314734 38 0
Oct1 HelaGSE14283 47315620 47315656 36 0
Oct1 HelaGSE14283 47360762 47360794 32 0
Oct1 HelaGSE14283 47380801 47380833 32 0
hScc1 BcellGSE12603 47384764 47385949 1185 0
hScc1 G2GSE9613 47384267 47385949 1682 0
p130 SenescentGSE19898 47317989 47318256 267 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
252 Unknown MicroArray miR-124 TNFRSF21 n_a 15685193
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000146072 G1-to-S transition n_a n_a "squamous cell, epithelium, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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