AutismKB 2.0

Annotation Detail for SESN1


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Basic Information Top
Gene Symbol:SESN1 ( MGC138241,MGC142129,PA26,RP11-787I22.1,SEST1 )
Gene Full Name: sestrin 1
Band: 6q21
Quick LinksEntrez ID:27244; OMIM: 606103; Uniprot ID:SESN1_HUMAN; ENSEMBL ID: ENSG00000080546; HGNC ID: 21595
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
293Phosphoserine.
314Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
83N-linkedHMM predict
211Phosphoserine(CAMK2)HMM predict
252Phosphoserine(CK2)HMM predict
263N-linkedHMM predict
293PhosphoserineHMM predict
293Phosphoserine(IKK)HMM predict
293Phosphoserine(ATM)HMM predict
293Phosphoserine(CK2)HMM predict
293Phosphoserine(CK1)HMM predict
314PhosphoserineHMM predict
314Phosphoserine(CK2)HMM predict
320Phosphothreonine(CDC2)HMM predict
320Phosphothreonine(MAPK)HMM predict
334SulfotyrosineHMM predict
361Phosphotyrosine(INSR)HMM predict
384N-linkedHMM predict
387Phosphotyrosine(INSR)HMM predict
388N-linkedHMM predict
422Phosphotyrosine(INSR)HMM predict
422SulfotyrosineHMM predict
443Phosphothreonine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014454
  • Location:chr6 109414339-109521969
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 109522339 109523188 849 794
ETS1 JurkatGSE17954 109522459 109524025 1566 1273
H3K4me3 colorectalcancer 109524003 109524391 388 2228
H3ac HepG2E 109523111 109523635 524 1404
H3ac HepG2E 109523930 109525031 1101 2511
H3ac HepG2E 109527756 109527940 184 5879
PHF8 HeLaGSE20725 109522103 109524054 1951 1109
PHF8 Hs68plusFBSGSE20725 109521974 109523884 1910 960
TFAP2C MCF7GSE21234 109522025 109522523 498 305
TFAP2C MCF7GSE21234 109522967 109523816 849 1422
hScc1 BcellGSE12603 109522235 109523255 1020 776
hScc1 G2GSE9613 109522304 109522864 560 615
p130 SenescentGSE19898 109522880 109523949 1069 1445
p130 shRbQuiescentGSE19898 109522534 109523860 1326 1228
p130 shRbSenescentGSE19898 109522754 109524085 1331 1450
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 109501249 109501627 378 0
CTCF CD4SISSRdata 109501249 109501627 378 0
CTCF G2GSE9613 109437034 109437639 605 0
CTCF G2GSE9613 109501195 109501531 336 0
Fos K562GSE19551 109437235 109438005 770 0
H3K4me3 colorectalcancer 109521499 109522085 586 0
H3ac HepG2E 109435959 109436469 510 0
H3ac HepG2E 109437765 109438280 515 0
H3ac HepG2E 109521499 109522085 586 0
KLF4 hESGSE17917 109437144 109437509 365 0
Myc K562GSE19551 109437163 109437915 752 0
Myc K562GSE19551 109473326 109473621 295 0
Myc hESGSE17917 109437217 109437580 363 0
Oct1 HelaGSE14283 109471026 109471123 97 0
Oct1 HelaGSE14283 109471193 109471250 57 0
hScc1 BcellGSE12603 109437277 109437420 143 0
hScc1 BcellGSE12603 109501080 109501531 451 0
hScc1 CdLSGSE12603 109501080 109501600 520 0
hScc1 G2GSE9613 109501080 109501564 484 0
p63 keratinocytesGSE17611 109436510 109437920 1410 0
p63 keratinocytesGSE17611 109442800 109443651 851 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-21 hsa-mir-21 17 17991735
hsa-miR-21* hsa-mir-21 17 17991735
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
23012 mRNA chr6 109437599 109438021 422 mRNA SESN1 chr6 109414339 109521970 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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