AutismKB 2.0

Annotation Detail for GLDC


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Basic Information Top
Gene Symbol:GLDC ( GCE,GCSP,HYGN1,MGC138198,MGC138200 )
Gene Full Name: glycine dehydrogenase (decarboxylating)
Band: 9p24.1
Quick LinksEntrez ID:2731; OMIM: 238300; Uniprot ID:GCSP_HUMAN; ENSEMBL ID: ENSG00000178445; HGNC ID: 4313
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
38Phosphoserine.
39Phosphoserine.
754N6-(pyridoxal phosphate)lysine (By
Location(AA) Modifications Resource
Location(AA) Modification Resource
37Phosphoserine(CK1)HMM predict
38Phosphoserine(CK1)HMM predict
140N-linkedHMM predict
175Phosphoserine(PKG)HMM predict
179Phosphotyrosine(INSR)HMM predict
235Phosphothreonine(PKC)HMM predict
339Phosphoserine(PKA)HMM predict
413N-linkedHMM predict
415Phosphothreonine(PKA)HMM predict
591Phosphotyrosine(EGFR)HMM predict
628Phosphothreonine(PKC)HMM predict
673Phosphotyrosine(INSR)HMM predict
709N-linkedHMM predict
801O-linkedHMM predict
858Phosphotyrosine(Jak)HMM predict
1008Phosphotyrosine(Syk)HMM predict
1010Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000170
  • Location:chr9 6522465-6635691
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Breast-CancerGSE22609 6654382 6655134 752 19067
ER E2-MCF7GSE14664 6636039 6636072 33 364
ER MCF7GSE19013 6654451 6655053 602 19061
H3K27me3 colorectalcancer 6638097 6638355 258 2535
H3ac HepG2E 6637047 6637663 616 1664
Oct1 H2O2-HelaGSE14283 6636040 6636073 33 365
Oct1 H2O2-HelaGSE14283 6643919 6643946 27 8241
PolII HeLaGSE12783 6635528 6636398 870 272
hScc1 BcellGSE12603 6635300 6636105 805 11
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 6520850 6520892 42 1595
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 6556397 6557510 1113 0
CTCF CD4GSE12889 6558141 6558410 269 0
CTCF CD4GSE12889 6575227 6575502 275 0
CTCF CD4SISSRdata 6558141 6558410 269 0
CTCF CD4SISSRdata 6575227 6575502 275 0
H3K27me3 colorectalcancer 6633211 6633706 495 0
H3K27me3 colorectalcancer 6634077 6635054 977 0
H3ac HepG2E 6634077 6634978 901 0
Nanog ESGSE20650 6584705 6584822 117 0
Nanog hESGSE18292 6575150 6575412 262 0
Oct1 H2O2-HelaGSE14283 6530100 6530132 32 0
Oct1 H2O2-HelaGSE14283 6634056 6634083 27 0
Oct1 HelaGSE14283 6570500 6570531 31 0
Oct4 ESGSE20650 6584715 6584811 96 0
P300 T0-glioblastomaGSE21026 6541807 6542620 813 0
STAT1 HeLaGSE12782 6631455 6632422 967 0
STAT1 HeLaGSE12783 6631372 6632388 1016 0
Sox2 hESGSE18292 6575144 6575550 406 0
Stat6 IL-4-hr4GSE17850 6524291 6524890 599 0
TAF k562GSE8489 6546837 6547019 182 0
hScc1 BcellGSE12603 6557166 6557504 338 0
hScc1 BcellGSE12603 6558064 6558527 463 0
hScc1 BcellGSE12603 6629030 6629385 355 0
hScc1 CdLSGSE12603 6588429 6588784 355 0
p63 keratinocytesGSE17611 6618580 6619410 830 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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