AutismKB 2.0

Annotation Detail for GLI3


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Basic Information Top
Gene Symbol:GLI3 ( ACLS,GCPS,PAP-A,PAPA,PAPA1,PAPB,PHS,PPDIV )
Gene Full Name: GLI family zinc finger 3
Band: 7p14.1
Quick LinksEntrez ID:2737; OMIM: 165240; Uniprot ID:GLI3_HUMAN; ENSEMBL ID: ENSG00000106571; HGNC ID: 4319
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
19Phosphoserine.
849Phosphoserine; by PKA.
865Phosphoserine; by PKA.
877Phosphoserine; by PKA.
907Phosphoserine; by PKA.
980Phosphoserine; by PKA.
1006Phosphoserine; by PKA.
Location(AA) Modifications Resource
19Phosphoserine.Swiss-Prot 53.0
19PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
7Phosphoserine(CK1)HMM predict
7Phosphoserine(IKK)HMM predict
10Phosphothreonine(PKC)HMM predict
36O-linkedHMM predict
37Phosphoserine(IKK)HMM predict
40Phosphoserine(CK2)HMM predict
72Phosphoserine(CK2)HMM predict
76Phosphoserine(CK1)HMM predict
77Phosphothreonine(CK2)HMM predict
79Phosphoserine(CK1)HMM predict
117Phosphotyrosine(INSR)HMM predict
117Phosphotyrosine(Syk)HMM predict
151Phosphoserine(CDK)HMM predict
160O-linkedHMM predict
163O-linkedHMM predict
165Phosphoserine(CDC2)HMM predict
165Phosphoserine(ATM)HMM predict
177Phosphoserine(CDC2)HMM predict
188Phosphoserine(ATM)HMM predict
191O-linkedHMM predict
191Phosphoserine(CDC2)HMM predict
191Phosphoserine(ATM)HMM predict
196Phosphotyrosine(INSR)HMM predict
196Phosphotyrosine(Syk)HMM predict
203Phosphotyrosine(Jak)HMM predict
210Phosphoserine(ATM)HMM predict
210PhosphoserineHMM predict
212Phosphoserine(CK1)HMM predict
225O-linkedHMM predict
281Phosphoserine(PKB)HMM predict
293Phosphothreonine(PKA)HMM predict
293Phosphothreonine(PKC)HMM predict
295Phosphoserine(PKG)HMM predict
297Phosphoserine(ATM)HMM predict
322N-linkedHMM predict
323N-linkedHMM predict
327Phosphoserine(CK1)HMM predict
327Phosphoserine(CK2)HMM predict
343Phosphoserine(MAPK)HMM predict
369Phosphoserine(PKA)HMM predict
369Phosphoserine(PKG)HMM predict
369Phosphoserine(CAMK2)HMM predict
369Phosphoserine(IKK)HMM predict
389O-linkedHMM predict
421Phosphoserine(IKK)HMM predict
424Phosphoserine(CK1)HMM predict
424Phosphoserine(CK2)HMM predict
445Phosphoserine(MAPK)HMM predict
576Phosphotyrosine(Jak)HMM predict
598N-linkedHMM predict
603N-linkedHMM predict
619Phosphothreonine(PKA)HMM predict
658Phosphoserine(IKK)HMM predict
660Phosphoserine(ATM)HMM predict
660Phosphoserine(IKK)HMM predict
662PhosphoserineHMM predict
664Phosphoserine(CDC2)HMM predict
681N-linkedHMM predict
703O-linkedHMM predict
703Phosphoserine(ATM)HMM predict
706O-linkedHMM predict
711Phosphoserine(IKK)HMM predict
712Phosphoserine(IKK)HMM predict
715Phosphoserine(CK1)HMM predict
715Phosphoserine(ATM)HMM predict
715Phosphoserine(IKK)HMM predict
718Phosphoserine(IKK)HMM predict
722N-linkedHMM predict
725N-linkedHMM predict
753O-linkedHMM predict
755O-linkedHMM predict
758O-linkedHMM predict
759O-linkedHMM predict
810N-linkedHMM predict
815N-linkedHMM predict
816N-linkedHMM predict
849Phosphoserine(IKK)HMM predict
852O-linkedHMM predict
864Phosphoserine(CK1)HMM predict
865Phosphoserine(PKG)HMM predict
865PhosphoserineHMM predict
872Phosphoserine(CDC2)HMM predict
876Phosphoserine(CK1)HMM predict
876Phosphoserine(CK2)HMM predict
877Phosphoserine(PKA)HMM predict
877Phosphoserine(PKG)HMM predict
877Phosphoserine(CAMK2)HMM predict
877Phosphoserine(CK1)HMM predict
877Phosphoserine(CK2)HMM predict
877Phosphoserine(IKK)HMM predict
880Phosphoserine(ATM)HMM predict
880Phosphoserine(IKK)HMM predict
890Phosphoserine(IKK)HMM predict
906Phosphoserine(CK1)HMM predict
907Phosphoserine(PKA)HMM predict
907Phosphoserine(PKG)HMM predict
907Phosphoserine(CAMK2)HMM predict
907Phosphoserine(CK1)HMM predict
907Phosphoserine(CK2)HMM predict
907Phosphoserine(IKK)HMM predict
910Phosphoserine(CK1)HMM predict
910Phosphoserine(ATM)HMM predict
943O-linkedHMM predict
943O-linkedHMM predict
943Phosphothreonine(MAPK)HMM predict
943Phosphothreonine(CDK)HMM predict
1026Phosphoserine(IKK)HMM predict
1026Phosphoserine(PKB)HMM predict
1048N-linkedHMM predict
1063Phosphoserine(CDK)HMM predict
1070O-linkedHMM predict
1072N-linkedHMM predict
1102Phosphoserine(ATM)HMM predict
1108Phosphotyrosine(EGFR)HMM predict
1215Phosphothreonine(PKC)HMM predict
1223Phosphotyrosine(INSR)HMM predict
1223Phosphotyrosine(Abl)HMM predict
1372Phosphoserine(ATM)HMM predict
1438N-linkedHMM predict
1451Phosphoserine(ATM)HMM predict
1461O-linkedHMM predict
1481Phosphoserine(CDC2)HMM predict
1481Phosphoserine(MAPK)HMM predict
1488O-linkedHMM predict
1520Phosphoserine(IKK)HMM predict
1524Phosphoserine(CDC2)HMM predict
1524Phosphoserine(ATM)HMM predict
1530N-linkedHMM predict
1540Phosphothreonine(PKC)HMM predict
1540Phosphothreonine(MAPK)HMM predict
1553Phosphoserine(IKK)HMM predict
1577AlanineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000168
  • Location:chr7 41970202-42229419
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 42234202 42234365 163 4864
CTCF G2GSE9613 42242381 42243970 1589 13756
H3K27me3 colorectalcancer 42233608 42234077 469 4423
H3K27me3 colorectalcancer 42238400 42238785 385 9173
Myc hESGSE17917 42243231 42243455 224 13924
TFAP2C MCF7GSE21234 42245114 42245535 421 15905
hScc1 BcellGSE12603 42242279 42242750 471 13095
hScc1 BcellGSE12603 42243759 42244318 559 14619
p130 SenescentGSE19898 42243315 42243823 508 14150
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 41963812 41963992 180 6301
Oct1 H2O2-HelaGSE14283 41952612 41952640 28 17577
P300 T30-glioblastomaGSE21026 41961527 41962527 1000 8176
TFAP2C MCF7GSE21234 41961892 41962599 707 7957
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 41972043 41972652 609 0
CTCF G2GSE9613 41983324 41984076 752 0
CTCF G2GSE9613 41986051 41986418 367 0
CTCF G2GSE9613 42020767 42020944 177 0
CTCF G2GSE9613 42031170 42031316 146 0
CTCF G2GSE9613 42087020 42087234 214 0
CTCF G2GSE9613 42098546 42098883 337 0
CTCF G2GSE9613 42100898 42102105 1207 0
CTCF G2GSE9613 42103988 42104400 412 0
CTCF G2GSE9613 42119322 42119485 163 0
CTCF G2GSE9613 42189378 42189573 195 0
CTCF G2GSE9613 42191861 42192572 711 0
ER Fulvestrant-MCF7GSE14664 41995555 41995588 33 0
ER Fulvestrant-MCF7GSE14664 42020406 42020439 33 0
ER Fulvestrant-MCF7GSE14664 42112768 42112805 37 0
ER MCF7GSE19013 42162570 42163014 444 0
FOXA1 MCF7GSE15244 42076026 42076558 532 0
FOXA1 MCF7GSE15244 42097521 42098689 1168 0
FOXA1 MCF7GSE15244 42110104 42110743 639 0
FOXA1 MCF7GSE15244 42157963 42159461 1498 0
FoxA1 MCF7MACSdata 42158661 42159104 443 0
GABP k562GSE8489 41970737 41971301 564 0
Myc K562GSE19551 41983330 41983594 264 0
Nanog ESGSE20650 42072059 42072579 520 0
Nanog hESGSE18292 42033528 42034224 696 0
Nanog hESGSE18292 42199079 42199674 595 0
Oct1 H2O2-HelaGSE14283 41992570 41992608 38 0
Oct1 H2O2-HelaGSE14283 42199564 42199591 27 0
Oct1 H2O2-HelaGSE14283 42200953 42200979 26 0
Oct1 HelaGSE14283 41992570 41992608 38 0
Oct1 HelaGSE14283 42020356 42020447 91 0
Oct1 HelaGSE14283 42079063 42079140 77 0
Oct1 HelaGSE14283 42093113 42093140 27 0
Oct1 HelaGSE14283 42199561 42199590 29 0
RARA MCF7GSE15244 42075768 42076814 1046 0
Rb QuiescentGSE19898 42113574 42113885 311 0
Rb SenescentGSE19898 42113503 42113817 314 0
Rb shRbQuiescentGSE19898 42113650 42113964 314 0
STAT1 HeLaGSE12782 42103401 42104752 1351 0
STAT1 HeLaGSE12783 42103361 42104624 1263 0
STAT1 IFNSISSRdata 42103577 42104554 977 0
Sox2 hESGSE18292 42033696 42034237 541 0
TAF HelaGSE8489 41974929 41975698 769 0
TFAP2C MCF7GSE21234 42182556 42182987 431 0
VDR GM10855-stimGSE22484 41990458 41991998 1540 0
VDR GM10861-stimGSE22484 41990484 41991813 1329 0
hScc1 BcellGSE12603 42020699 42020909 210 0
hScc1 BcellGSE12603 42119485 42119674 189 0
hScc1 G2GSE9613 41972147 41972652 505 0
hScc1 G2GSE9613 41983180 41984076 896 0
p130 shRbSenescentGSE19898 42157440 42157601 161 0
p63 keratinocytesGSE17611 42204159 42205001 842 0
p63 keratinocytesGSE17611 42225312 42226098 786 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-141 hsa-mir-141 12 18698484
hsa-miR-141 hsa-mir-141 12 18698484
hsa-miR-141* hsa-mir-141 12 18698484
hsa-miR-141* hsa-mir-141 12 18698484
hsa-miR-200a hsa-mir-200a 1 18698484
hsa-miR-200a hsa-mir-200a 1 18698484
hsa-miR-200a* hsa-mir-200a 1 18698484
hsa-miR-200a* hsa-mir-200a 1 18698484
hsa-miR-200b hsa-mir-200b 1 18698484
hsa-miR-200b hsa-mir-200b 1 18698484
hsa-miR-200b* hsa-mir-200b 1 18698484
hsa-miR-200b* hsa-mir-200b 1 18698484
hsa-miR-200c hsa-mir-200c 12 18698484
hsa-miR-200c hsa-mir-200c 12 18698484
hsa-miR-200c* hsa-mir-200c 12 18698484
hsa-miR-200c* hsa-mir-200c 12 18698484
hsa-miR-205 hsa-mir-205 1 18698484
hsa-miR-205 hsa-mir-205 1 18698484
hsa-miR-25 hsa-mir-25 7 21256124
hsa-miR-25 hsa-mir-25 7 21256124
hsa-miR-25* hsa-mir-25 7 21256124
hsa-miR-25* hsa-mir-25 7 21256124
hsa-miR-32 hsa-mir-32 9 21256124
hsa-miR-32 hsa-mir-32 9 21256124
hsa-miR-32* hsa-mir-32 9 21256124
hsa-miR-32* hsa-mir-32 9 21256124
hsa-miR-363 hsa-mir-363 X 21256124
hsa-miR-363 hsa-mir-363 X 21256124
hsa-miR-363* hsa-mir-363 X 21256124
hsa-miR-363* hsa-mir-363 X 21256124
hsa-miR-367 hsa-mir-367 4 21256124
hsa-miR-367 hsa-mir-367 4 21256124
hsa-miR-367* hsa-mir-367 4 21256124
hsa-miR-367* hsa-mir-367 4 21256124
hsa-miR-429 hsa-mir-429 1 18698484
hsa-miR-429 hsa-mir-429 1 18698484
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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