Annotation Detail for GNAO1

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Basic Information Top

Gene Symbol:	GNAO1 ( DKFZp686O0962,G-ALPHA-o,GNAO )
Gene Full Name:	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Band:	16q13
Quick Links	Entrez ID:2775; OMIM: 139311; Uniprot ID:GNAO_HUMAN; ENSEMBL ID: ENSG00000087258; HGNC ID: 4389
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:0 results

Location(AA)	Modification
179	ADP-ribosylarginine; by cholera toxin (By
351	ADP-ribosylcysteine; by pertussis toxin

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_020988
Location:chr16 54783648-54948647
strand:+

Upstream the gene:0 results
Downstream the gene:2 results
Inside the gene:12 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
hScc1	Bcell	GSE12603	54949015	54949263	248	492
p130	shRbQuiescent	GSE19898	54948505	54949413	908	312

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	54947908	54948114	206	0
CTCF	CD4	SISSRdata	54947908	54948114	206	0
CTCF	G2	GSE9613	54937169	54937423	254	0
CTCF	G2	GSE9613	54947571	54948312	741	0
H3ac	HepG2	E	54948043	54949119	1076	0
Myc	K562	GSE19551	54947743	54948270	527	0
TFAP2C	MCF7	GSE21234	54935390	54937408	2018	0
TFAP2C	MCF7	GSE21234	54941061	54941743	682	0
hScc1	Bcell	GSE12603	54938741	54939336	595	0
hScc1	Bcell	GSE12603	54947304	54948419	1115	0
hScc1	CdLS	GSE12603	54947783	54948419	636	0
hScc1	G2	GSE9613	54947464	54948348	884	0

Validated miRNA targets

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
10029	mRNA	GNAO1	chr16	54783648	54948651	202	mRNA	GNAO1	chr16	54782879	54867384	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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