Annotation Detail for GNRHR

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Basic Information Top

Gene Symbol:	GNRHR ( GNRHR1,GRHR,LHRHR,LRHR )
Gene Full Name:	gonadotropin-releasing hormone receptor
Band:	4q13.2
Quick Links	Entrez ID:2798; OMIM: 138850; Uniprot ID:GNRHR_HUMAN; ENSEMBL ID: ENSG00000109163; HGNC ID: 4421
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:2 results
Predicted PTM Sites by profile HMM from dbPTM:6 results

Location(AA)	Modification
18	N-linked (GlcNAc...) (Potential).
102	N-linked (GlcNAc...) (Potential).

Location(AA)	Modification	Resource
102	N-linked	HMM predict
153	Phosphoserine(CK1)	HMM predict
252	N-linked	HMM predict
256	N-linked	HMM predict
257	N-linked	HMM predict
265	Phosphothreonine(PKC)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_000406
Location:chr4 68285700-68304398
strand:-

Upstream the gene:0 results
Downstream the gene:7 results
Inside the gene:3 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	68271555	68271758	203	14044
Oct1	Hela	GSE14283	68274175	68274211	36	11508
Oct1	Hela	GSE14283	68285051	68285121	70	615
Rb	Growing	GSE19898	68270534	68270833	299	15017
STAT1	HeLa	GSE12782	68269338	68271048	1710	15508
STAT1	HeLa	GSE12783	68268956	68271014	2058	15716
hScc1	Bcell	GSE12603	68271592	68271758	166	14026

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	68295108	68295379	271	0
CTCF	CD4	SISSRdata	68295108	68295379	271	0
CTCF	G2	GSE9613	68295183	68295425	242	0

Validated miRNA targets

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
19747	HTC		chr4	68437008	68438078	1070	mRNA	GNRHR	chr4	68431871	68450570	Non-exonic Bidirectional (NOB) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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