Annotation Detail for NKIRAS2

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Basic Information Top

Gene Symbol:	NKIRAS2 ( DKFZp434N1526,KBRAS2,MGC74742,kappaB-Ras2 )
Gene Full Name:	NFKB inhibitor interacting Ras-like 2
Band:	17q21.2
Quick Links	Entrez ID:28511; OMIM: 604497; Uniprot ID:KBRS2_HUMAN; ENSEMBL ID: ENSG00000168256; HGNC ID: 17898
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:1 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:3 results

Location(AA)	Modification
43	Effector region.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001001349
Location:chr17 37422563-37431179
strand:+

Upstream the gene:0 results
Downstream the gene:0 results
Inside the gene:14 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	37425422	37425719	297	0
CTCF	CD4	SISSRdata	37425422	37425719	297	0
CTCF	G2	GSE9613	37425238	37425781	543	0
ETS1	Jurkat	GSE17954	37421772	37423744	1972	0
ETS1	Jurkat	GSE17954	37425103	37426004	901	0
GABP	Hela	GSE8489	37423904	37424517	613	0
H3ac	HepG2	E	37423331	37425238	1907	0
PHF8	HeLa	GSE20725	37421969	37423601	1632	0
PHF8	HeLa	GSE20725	37425138	37425980	842	0
PHF8	Hs68plusFBS	GSE20725	37422260	37424059	1799	0
Rb	Growing	GSE19898	37425378	37425633	255	0
Rb	Quiescent	GSE19898	37425441	37425636	195	0
TAF	k562	GSE8489	37423568	37425203	1635	0
p130	shRbQuiescent	GSE19898	37422281	37423218	937	0

Validated miRNA targets

miR Walk:8 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	20351193
hsa-let-7a	hsa-let-7a-2	11	20351193
hsa-let-7a	hsa-let-7a-3	22	20351193
hsa-miR-125b	hsa-mir-125b-1	11	20351193
hsa-miR-125b	hsa-mir-125b-2	21	20351193
hsa-miR-29b	hsa-mir-29b-1	7	19956414
hsa-miR-29b	hsa-mir-29b-2	1	19956414
hsa-miR-29b-1*	hsa-mir-29b-1	7	19956414

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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