AutismKB 2.0

Annotation Detail for GRK5


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Basic Information Top
Gene Symbol:GRK5 ( FLJ39780,GPRK5 )
Gene Full Name: G protein-coupled receptor kinase 5
Band: 10q26.11
Quick LinksEntrez ID:2869; OMIM: 600870; Uniprot ID:GRK5_HUMAN; ENSEMBL ID: ENSG00000198873; HGNC ID: 4544
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
484Phosphoserine; by autocatalysis (By
485Phosphothreonine; by autocatalysis (By
Location(AA) Modifications Resource
484Phosphoserine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
484Phosphoserine (GRK-5)Phospho.ELM 6.0
485Phosphothreonine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
485Phosphothreonine (GRK-5)Phospho.ELM 6.0
Location(AA) Modification Resource
40Phosphoserine(ATM)HMM predict
111Phosphothreonine(CDK)HMM predict
114Phosphoserine(CDC2)HMM predict
127Phosphoserine(ATM)HMM predict
161SulfotyrosineHMM predict
161Phosphotyrosine(Syk)HMM predict
309Phosphotyrosine(SRC)HMM predict
351Phosphotyrosine(INSR)HMM predict
418Phosphoserine(IKK)HMM predict
499Phosphotyrosine(Syk)HMM predict
499Phosphotyrosine(EGFR)HMM predict
499Phosphotyrosine(Jak)HMM predict
506Phosphoserine(IKK)HMM predict
530N-linkedHMM predict
561N-linkedHMM predict
562N-linkedHMM predict
566Phosphoserine(CDK)HMM predict
566Phosphoserine(CDC2)HMM predict
568Phosphoserine(CK2)HMM predict
568Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005308
  • Location:chr10 120957186-121205119
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 120948981 120949223 242 8085
CTCF CD4SISSRdata 120948981 120949223 242 8085
Rb GrowingGSE19898 120949076 120949254 178 8022
hScc1 BcellGSE12603 120948083 120948476 393 8907
hScc1 BcellGSE12603 120948931 120949332 401 8055
hScc1 BcellGSE12603 120955904 120957066 1162 702
hScc1 CdLSGSE12603 120948083 120948590 507 8850
hScc1 CdLSGSE12603 120948931 120949478 547 7982
hScc1 CdLSGSE12603 120956091 120957066 975 608
hScc1 G2GSE9613 120948931 120949478 547 7982
hScc1 G2GSE9613 120956159 120957066 907 574
p130 SenescentGSE19898 120947468 120948032 564 9437
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NFkBII GM12892GSE19485 121204808 121205993 1185 281
Nanog hESGSE18292 121211871 121212249 378 6941
RARG MCF7GSE15244 121210813 121211058 245 5816
TFAP2C MCF7GSE21234 121210874 121211315 441 5975
hScc1 BcellGSE12603 121215699 121216030 331 10745
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 121199257 121200001 744 0
CBP T30-glioblastomaGSE21026 121055098 121056213 1115 0
CBP T30-glioblastomaGSE21026 121120102 121121284 1182 0
CBP T30-glioblastomaGSE21026 121151118 121151953 835 0
CTCF CD4GSE12889 121056167 121056577 410 0
CTCF CD4GSE12889 121166493 121166683 190 0
CTCF CD4GSE12889 121194937 121195268 331 0
CTCF CD4SISSRdata 121056167 121056577 410 0
CTCF CD4SISSRdata 121166493 121166683 190 0
CTCF CD4SISSRdata 121194937 121195268 331 0
CTCF HelaGSE12889 121166433 121166740 307 0
CTCF HelaGSE12889 121194878 121195237 359 0
CTCF JurkatGSE12889 121194929 121195176 247 0
ER E2-MCF7GSE14664 121143029 121143158 129 0
ER E2-MCF7GSE14664 121143190 121143295 105 0
ER E2-MCF7GSE14664 121145592 121145633 41 0
Fos K562GSE19551 121020927 121021360 433 0
Fos K562GSE19551 121055297 121056139 842 0
Fos K562GSE19551 121065095 121065541 446 0
Fos K562GSE19551 121128271 121128651 380 0
H3K4me2 HCT116GSE10453 120957631 120957987 356 0
H3K4me3 colorectalcancer 120957550 120958484 934 0
H3ac HepG2E 120957452 120959728 2276 0
H3ac HepG2E 120987230 120987779 549 0
H3ac HepG2E 121002632 121003973 1341 0
H3ac HepG2E 121067631 121068265 634 0
KLF4 hESGSE17917 121109236 121109594 358 0
KLF4 hESGSE17917 121116663 121116821 158 0
NFkBII GM10847GSE19485 121018037 121019196 1159 0
NFkBII GM12878GSE19485 121017993 121019216 1223 0
NFkBII GM12892GSE19485 121017996 121019241 1245 0
NFkBII GM18526GSE19485 121018087 121019213 1126 0
Oct1 H2O2-HelaGSE14283 121017389 121017418 29 0
Oct1 H2O2-HelaGSE14283 121077559 121077587 28 0
Oct1 H2O2-HelaGSE14283 121166295 121166345 50 0
Oct1 HelaGSE14283 120962273 120962309 36 0
Oct1 HelaGSE14283 121005162 121005209 47 0
Oct1 HelaGSE14283 121017389 121017418 29 0
Oct1 HelaGSE14283 121145594 121145623 29 0
Oct1 HelaGSE14283 121166291 121166349 58 0
P300 T0-glioblastomaGSE21026 121151156 121151805 649 0
P300 T30-glioblastomaGSE21026 121020786 121021591 805 0
P300 T30-glioblastomaGSE21026 121055189 121056092 903 0
P300 T30-glioblastomaGSE21026 121119775 121121430 1655 0
RARA MCF7GSE15244 121020878 121021198 320 0
RARA MCF7GSE15244 121024240 121025591 1351 0
RARG MCF7GSE15244 121003050 121003532 482 0
RARG MCF7GSE15244 121020913 121021468 555 0
RARG MCF7GSE15244 121127614 121128093 479 0
RNAII Tamoxifen-MCF7GSE14664 121127226 121127317 91 0
Rb QuiescentGSE19898 121113074 121113272 198 0
Rb shRbSenescenceGSE19898 121106146 121106313 167 0
TFAP2C MCF7GSE21234 121052365 121052812 447 0
TFAP2C MCF7GSE21234 121120422 121120922 500 0
TFAP2C MCF7GSE21234 121127356 121127774 418 0
USF1 HepG2E 121052601 121053286 685 0
USF1 HepG2E 121066646 121067132 486 0
USF1 HepG2E 121088067 121088350 283 0
USF2 HepG2E 121066646 121067355 709 0
hScc1 BcellGSE12603 120959135 120959420 285 0
hScc1 BcellGSE12603 121005658 121006093 435 0
hScc1 BcellGSE12603 121014164 121014421 257 0
hScc1 BcellGSE12603 121040704 121040987 283 0
hScc1 BcellGSE12603 121055572 121055966 394 0
hScc1 BcellGSE12603 121159306 121159523 217 0
hScc1 BcellGSE12603 121161659 121162026 367 0
hScc1 BcellGSE12603 121166411 121167205 794 0
hScc1 BcellGSE12603 121194365 121196265 1900 0
hScc1 BcellGSE12603 121200315 121200797 482 0
hScc1 BcellGSE12603 121204271 121204642 371 0
hScc1 CdLSGSE12603 120958777 120959364 587 0
hScc1 CdLSGSE12603 121039892 121040240 348 0
hScc1 CdLSGSE12603 121049170 121049570 400 0
hScc1 CdLSGSE12603 121056008 121056387 379 0
hScc1 CdLSGSE12603 121166411 121166773 362 0
hScc1 CdLSGSE12603 121194402 121195262 860 0
hScc1 G2GSE9613 121194365 121195369 1004 0
p130 QuiescentGSE19898 120987473 120987653 180 0
p130 QuiescentGSE19898 121151539 121151797 258 0
p130 SenescentGSE19898 121064518 121064729 211 0
p130 SenescentGSE19898 121065513 121065800 287 0
p130 SenescentGSE19898 121066292 121066560 268 0
p130 SenescentGSE19898 121138253 121138472 219 0
p130 SenescentGSE19898 121159142 121159780 638 0
p130 shRbQuiescentGSE19898 121064823 121065425 602 0
p130 shRbSenescentGSE19898 121055573 121055837 264 0
p63 keratinocytesGSE17611 121074223 121075462 1239 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
3748 mRNA GRK5 chr10 120957186 121205120 1401 EST chr10 121084131 121085532 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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