AutismKB 2.0

Annotation Detail for ANK2


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Basic Information Top
Gene Symbol:ANK2 ( DKFZp686M09125,DKFZp686P0948,FLJ38277,LQT4 )
Gene Full Name: ankyrin 2, neuronal
Band: 4q25-q26
Quick LinksEntrez ID:287; OMIM: 106410; Uniprot ID:ANK2_HUMAN; ENSEMBL ID: ENSG00000145362; HGNC ID: 493
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
31Phosphoserine (By similarity).
34Phosphoserine (By similarity).
378Phosphotyrosine (By similarity).
531Phosphotyrosine (By similarity).
846Phosphoserine (By similarity).
898Phosphoserine (By similarity).
911Phosphoserine.
1349Phosphotyrosine (By similarity).
1428Phosphoserine (By similarity).
1475Phosphoserine.
1490Phosphothreonine.
2550Phosphothreonine.
3060Phosphothreonine (By similarity).
3240Phosphoserine (By similarity).
3329Phosphoserine (By similarity).
3357Phosphoserine (By similarity).
3376Phosphoserine (By similarity).
3377Phosphotyrosine (By similarity).
3702Phosphoserine (By similarity).
3743Phosphothreonine (By similarity).
3760Phosphoserine.
3762Phosphoserine.
3764Phosphothreonine.
3769Phosphoserine (By similarity).
3770Phosphothreonine (By similarity).
3790Phosphoserine (By similarity).
3811Phosphothreonine (By similarity).
Location(AA) Modifications Resource
31PhosphoserinePhospho.ELM 6.0
34PhosphoserinePhospho.ELM 6.0
1467PhosphoserinePhospho.ELM 6.0
2435PhosphoserinePhospho.ELM 6.0
2439PhosphoserinePhospho.ELM 6.0
2550Phosphothreonine.Swiss-Prot 53.0
2550PhosphothreoninePhospho.ELM 6.0
Location(AA) Modification Resource
17N-linkedHMM predict
89Phosphoserine(PKA)HMM predict
89Phosphoserine(PKB)HMM predict
92O-linkedHMM predict
155N-linkedHMM predict
185N-linkedHMM predict
227N-linkedHMM predict
499Phosphothreonine(MAPK)HMM predict
528O-linkedHMM predict
532O-linkedHMM predict
565Phosphothreonine(MAPK)HMM predict
598Phosphothreonine(MAPK)HMM predict
664Phosphothreonine(MAPK)HMM predict
694Phosphoserine(IKK)HMM predict
729Phosphotyrosine(INSR)HMM predict
762Phosphotyrosine(INSR)HMM predict
763Phosphothreonine(MAPK)HMM predict
763Phosphothreonine(CDK)HMM predict
788N-linkedHMM predict
793N-linkedHMM predict
806Phosphotyrosine(INSR)HMM predict
821O-linkedHMM predict
822O-linkedHMM predict
824O-linkedHMM predict
826O-linkedHMM predict
861Phosphotyrosine(INSR)HMM predict
861Phosphotyrosine(Jak)HMM predict
874Phosphoserine(IKK)HMM predict
878Phosphoserine(ATM)HMM predict
898Phosphoserine(PKA)HMM predict
898Phosphoserine(PKC)HMM predict
903Phosphoserine(CK1)HMM predict
907Phosphoserine(PKA)HMM predict
909Phosphothreonine(PKC)HMM predict
962Phosphoserine(CDC2)HMM predict
962Phosphoserine(CDK)HMM predict
962PhosphoserineHMM predict
982MethylarginineHMM predict
999Phosphothreonine(PKA)HMM predict
1005Phosphothreonine(PKA)HMM predict
1079SulfotyrosineHMM predict
1139O-linkedHMM predict
1156Phosphothreonine(PKC)HMM predict
1247Phosphothreonine(MAPK)HMM predict
1261N-linkedHMM predict
1285Phosphotyrosine(EGFR)HMM predict
1349Phosphotyrosine(EGFR)HMM predict
1416N-linkedHMM predict
1422Phosphotyrosine(INSR)HMM predict
1428Phosphoserine(CK1)HMM predict
1428Phosphoserine(CK2)HMM predict
1448Phosphoserine(CK1)HMM predict
1543Phosphoserine(IKK)HMM predict
1550Phosphoserine(CK1)HMM predict
1581Phosphotyrosine(EGFR)HMM predict
1624Phosphothreonine(PKC)HMM predict
1699Phosphoserine(CK2)HMM predict
1699PhosphoserineHMM predict
1703Phosphoserine(CK1)HMM predict
1717O-linkedHMM predict
1717O-linkedHMM predict
1717Phosphothreonine(PKC)HMM predict
1722Phosphoserine(CDC2)HMM predict
1722Phosphoserine(MAPK)HMM predict
1768Phosphothreonine(PKC)HMM predict
1789Phosphoserine(CDC2)HMM predict
1789Phosphoserine(CDK)HMM predict
1791Phosphoserine(CDC2)HMM predict
1794Phosphothreonine(PKC)HMM predict
1798Phosphoserine(IKK)HMM predict
1799Phosphothreonine(PKC)HMM predict
1801Phosphoserine(CK1)HMM predict
1802Phosphoserine(CDC2)HMM predict
1806Phosphothreonine(PKC)HMM predict
1813O-linkedHMM predict
1813Phosphoserine(CDC2)HMM predict
1813Phosphoserine(MAPK)HMM predict
1813Phosphoserine(CDK)HMM predict
1815Phosphoserine(CK2)HMM predict
1818Phosphothreonine(PKC)HMM predict
1818Phosphothreonine(CDK)HMM predict
1822Phosphoserine(IKK)HMM predict
1825Phosphoserine(MAPK)HMM predict
1830Phosphothreonine(PKC)HMM predict
1834Phosphoserine(IKK)HMM predict
1837O-linkedHMM predict
1837Phosphoserine(CK2)HMM predict
1838Phosphoserine(CDC2)HMM predict
1840Phosphoserine(CK1)HMM predict
1842Phosphothreonine(PKC)HMM predict
1846Phosphoserine(IKK)HMM predict
1849Phosphoserine(CDK)HMM predict
1858Phosphoserine(MAPK)HMM predict
1858Phosphoserine(IKK)HMM predict
1861O-linkedHMM predict
1865Phosphothreonine(PKC)HMM predict
1872O-linkedHMM predict
1872Phosphoserine(CDC2)HMM predict
1872Phosphoserine(MAPK)HMM predict
1884Phosphoserine(CDC2)HMM predict
1884Phosphoserine(CDK)HMM predict
1884Phosphoserine(CDK)HMM predict
1889Phosphothreonine(CDK)HMM predict
1896Phosphoserine(CDC2)HMM predict
1900Phosphothreonine(PKC)HMM predict
1907Phosphoserine(CDC2)HMM predict
1907Phosphoserine(CDK)HMM predict
1924Phosphothreonine(PKC)HMM predict
1931Phosphoserine(CDC2)HMM predict
1931Phosphoserine(CDK)HMM predict
1933Phosphoserine(CK2)HMM predict
1943Phosphoserine(CDC2)HMM predict
1943Phosphoserine(MAPK)HMM predict
1943Phosphoserine(CDK)HMM predict
2005Phosphothreonine(PKC)HMM predict
2014N-linkedHMM predict
2094Phosphoserine(CDK)HMM predict
2100Phosphoserine(PKB)HMM predict
2117Phosphotyrosine(EGFR)HMM predict
2123Phosphoserine(CK2)HMM predict
2139Phosphoserine(CDC2)HMM predict
2142N-linkedHMM predict
2143O-linkedHMM predict
2180Phosphoserine(IKK)HMM predict
2193Phosphoserine(CK2)HMM predict
2206Phosphothreonine(MAPK)HMM predict
2206Phosphothreonine(CDK)HMM predict
2217Phosphoserine(CDC2)HMM predict
2217Phosphoserine(CDK)HMM predict
2217Phosphoserine(ATM)HMM predict
2231O-linkedHMM predict
2231Phosphoserine(PKG)HMM predict
2236O-linkedHMM predict
2267O-linkedHMM predict
2287Phosphoserine(CDC2)HMM predict
2287Phosphoserine(CDK)HMM predict
2287PhosphoserineHMM predict
2325Phosphoserine(CDK)HMM predict
2332Phosphothreonine(CK2)HMM predict
2339Phosphoserine(IKK)HMM predict
2340O-linkedHMM predict
2342Phosphothreonine(CK2)HMM predict
2343Phosphoserine(CK2)HMM predict
2372Phosphoserine(CDC2)HMM predict
2413N-linkedHMM predict
2418Phosphothreonine(CDC2)HMM predict
2418Phosphothreonine(CDK)HMM predict
2425Phosphoserine(CDC2)HMM predict
2439Phosphoserine(CDC2)HMM predict
2439Phosphoserine(CDK)HMM predict
2439Phosphoserine(ATM)HMM predict
2439Phosphoserine(IKK)HMM predict
2439PhosphoserineHMM predict
2483Phosphoserine(CK2)HMM predict
2488Phosphoserine(CK1)HMM predict
2488Phosphoserine(IKK)HMM predict
2501Phosphoserine(CDC2)HMM predict
2501Phosphoserine(CDK)HMM predict
2501Phosphoserine(IKK)HMM predict
2504O-linkedHMM predict
2504Phosphoserine(CDC2)HMM predict
2504Phosphoserine(CDK)HMM predict
2504Phosphoserine(ATM)HMM predict
2504Phosphoserine(IKK)HMM predict
2507Phosphothreonine(CDC2)HMM predict
2507Phosphothreonine(MAPK)HMM predict
2509O-linkedHMM predict
2509Phosphoserine(CK1)HMM predict
2509Phosphoserine(MAPK)HMM predict
2515Phosphotyrosine(SRC)HMM predict
2518Phosphothreonine(MAPK)HMM predict
2522O-linkedHMM predict
2522O-linkedHMM predict
2541Phosphoserine(CK1)HMM predict
2550Phosphothreonine(PKA)HMM predict
2550Phosphothreonine(CK2)HMM predict
2550Phosphothreonine(MAPK)HMM predict
2550PhosphothreonineHMM predict
2578Phosphotyrosine(EGFR)HMM predict
2578Phosphotyrosine(Jak)HMM predict
2587Phosphoserine(CK2)HMM predict
2587Phosphoserine(IKK)HMM predict
2588Phosphoserine(CK1)HMM predict
2589Phosphoserine(CK1)HMM predict
2590Phosphoserine(CK2)HMM predict
2591Phosphoserine(CK1)HMM predict
2591Phosphoserine(CK2)HMM predict
2591Phosphoserine(ATM)HMM predict
2628Phosphoserine(PKA)HMM predict
2628Phosphoserine(PKG)HMM predict
2628Phosphoserine(CK2)HMM predict
2628PhosphoserineHMM predict
2629Phosphoserine(PKG)HMM predict
2630Phosphoserine(CK2)HMM predict
2631Phosphoserine(CK1)HMM predict
2633Phosphoserine(CK1)HMM predict
2633Phosphoserine(CK2)HMM predict
2660O-linkedHMM predict
2660Phosphoserine(CDC2)HMM predict
2660Phosphoserine(MAPK)HMM predict
2660Phosphoserine(CDK)HMM predict
2660Phosphoserine(MAPK)HMM predict
2664O-linkedHMM predict
2665Phosphoserine(IKK)HMM predict
2668Phosphoserine(IKK)HMM predict
2669N-linkedHMM predict
2670Phosphoserine(CK2)HMM predict
2671Phosphoserine(CDC2)HMM predict
2706Phosphoserine(CK1)HMM predict
2726Phosphotyrosine(EGFR)HMM predict
2748PhosphoserineHMM predict
2752O-linkedHMM predict
2758O-linkedHMM predict
2789Phosphothreonine(CK2)HMM predict
2797Phosphoserine(CK2)HMM predict
2808O-linkedHMM predict
2812O-linkedHMM predict
2812Phosphoserine(CK1)HMM predict
2814O-linkedHMM predict
2816Phosphoserine(CK1)HMM predict
2859Phosphoserine(CK1)HMM predict
2859Phosphoserine(ATM)HMM predict
2859Phosphoserine(IKK)HMM predict
2863Phosphoserine(CK1)HMM predict
2863Phosphoserine(IKK)HMM predict
2887Phosphotyrosine(INSR)HMM predict
2887SulfotyrosineHMM predict
2893Phosphoserine(CDC2)HMM predict
2895Phosphotyrosine(Syk)HMM predict
2905Phosphoserine(CK1)HMM predict
2905Phosphoserine(CDK)HMM predict
2909Phosphoserine(CK1)HMM predict
2909Phosphoserine(IKK)HMM predict
2916N-linkedHMM predict
2924O-linkedHMM predict
2927Phosphotyrosine(SRC)HMM predict
2933Phosphoserine(MAPK)HMM predict
2943Phosphoserine(CDC2)HMM predict
2944O-linkedHMM predict
2945Phosphoserine(CK1)HMM predict
2947O-linkedHMM predict
2964Phosphoserine(ATM)HMM predict
2977Phosphoserine(IKK)HMM predict
2981Phosphoserine(IKK)HMM predict
2985O-linkedHMM predict
3009Phosphoserine(CK1)HMM predict
3046O-linkedHMM predict
3046Phosphothreonine(MAPK)HMM predict
3050O-linkedHMM predict
3050Phosphothreonine(MAPK)HMM predict
3054Phosphothreonine(MAPK)HMM predict
3054Phosphothreonine(CDK)HMM predict
3056Phosphothreonine(MAPK)HMM predict
3060Phosphothreonine(MAPK)HMM predict
3138Phosphoserine(CK1)HMM predict
3154Phosphoserine(CK2)HMM predict
3179Phosphothreonine(CDC2)HMM predict
3179Phosphothreonine(MAPK)HMM predict
3179Phosphothreonine(CDK)HMM predict
3214PhosphoserineHMM predict
3240Phosphoserine(ATM)HMM predict
3240Phosphoserine(IKK)HMM predict
3243Phosphoserine(CK2)HMM predict
3244Phosphoserine(CK1)HMM predict
3244Phosphoserine(CK2)HMM predict
3244Phosphoserine(CDK)HMM predict
3250Phosphoserine(CK2)HMM predict
3278O-linkedHMM predict
3279O-linkedHMM predict
3279O-linkedHMM predict
3280O-linkedHMM predict
3291Phosphoserine(CK1)HMM predict
3291Phosphoserine(CK2)HMM predict
3291Phosphoserine(ATM)HMM predict
3329Phosphoserine(CK2)HMM predict
3353N-linkedHMM predict
3355Phosphoserine(CK1)HMM predict
3357PhosphoserineHMM predict
3362Phosphoserine(IKK)HMM predict
3363Phosphoserine(CK1)HMM predict
3395Phosphoserine(CK1)HMM predict
3417Phosphothreonine(PKC)HMM predict
3424Phosphothreonine(PKA)HMM predict
3425Phosphoserine(CDC2)HMM predict
3449Phosphoserine(CK2)HMM predict
3470Phosphoserine(CK2)HMM predict
3474Phosphoserine(CK1)HMM predict
3475Phosphoserine(CK2)HMM predict
3476Phosphoserine(CK1)HMM predict
3494Phosphoserine(CK1)HMM predict
3494Phosphoserine(IKK)HMM predict
3667Phosphoserine(CK2)HMM predict
3680PhosphoserineHMM predict
3685Phosphoserine(ATM)HMM predict
3731Phosphoserine(CK1)HMM predict
3731Phosphoserine(CK2)HMM predict
3732Phosphoserine(CK1)HMM predict
3735Phosphotyrosine(INSR)HMM predict
3735SulfotyrosineHMM predict
3760Phosphoserine(CDC2)HMM predict
3760Phosphoserine(CDK)HMM predict
3760Phosphoserine(IKK)HMM predict
3762O-linkedHMM predict
3764O-linkedHMM predict
3764Phosphothreonine(CDC2)HMM predict
3764Phosphothreonine(MAPK)HMM predict
3770Phosphothreonine(CK2)HMM predict
3778Phosphotyrosine(Abl)HMM predict
3781Phosphothreonine(MAPK)HMM predict
3783Phosphothreonine(MAPK)HMM predict
3784Phosphoserine(MAPK)HMM predict
3800Phosphoserine(CK1)HMM predict
3806Phosphoserine(CK1)HMM predict
3807Phosphoserine(CDC2)HMM predict
3854Phosphotyrosine(INSR)HMM predict
3854SulfotyrosineHMM predict
3867Phosphothreonine(PKC)HMM predict
3880Phosphothreonine(CK2)HMM predict
3903Phosphotyrosine(EGFR)HMM predict
3903Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001148
  • Location:chr4 114190318-114524333
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Myc hESGSE17917 114189708 114190021 313 454
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 114535258 114535647 389 11119
CTCF CD4SISSRdata 114535258 114535647 389 11119
CTCF G2GSE9613 114535317 114535701 384 11176
CTCF G2GSE9613 114538797 114539051 254 14591
Oct1 H2O2-HelaGSE14283 114541690 114541723 33 17373
Oct1 HelaGSE14283 114541689 114541723 34 17373
hScc1 BcellGSE12603 114535424 114535771 347 11264
hScc1 G2GSE9613 114535317 114535771 454 11211
p130 QuiescentGSE19898 114535459 114535620 161 11206
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 114373549 114373762 213 0
CTCF CD4GSE12889 114419034 114419212 178 0
CTCF CD4GSE12889 114496173 114496322 149 0
CTCF CD4SISSRdata 114419034 114419212 178 0
CTCF CD4SISSRdata 114496173 114496322 149 0
CTCF G2GSE9613 114209704 114209996 292 0
CTCF G2GSE9613 114235363 114235801 438 0
CTCF G2GSE9613 114236547 114236882 335 0
CTCF G2GSE9613 114257407 114257715 308 0
CTCF G2GSE9613 114286229 114286380 151 0
CTCF G2GSE9613 114322108 114322394 286 0
CTCF G2GSE9613 114418637 114419262 625 0
CTCF G2GSE9613 114433013 114433222 209 0
CTCF G2GSE9613 114495888 114496660 772 0
CTCF G2GSE9613 114499242 114499963 721 0
CTCF G2GSE9613 114510092 114510352 260 0
ER E2-MCF7GSE14664 114368290 114368323 33 0
ER E2-MCF7GSE14664 114402528 114402571 43 0
ER Fulvestrant-MCF7GSE14664 114368147 114368197 50 0
ER MCF7GSE19013 114282358 114283004 646 0
FOXA1 MCF7GSE15244 114282288 114283126 838 0
FOXA1 eGFPGSE10845 114282288 114283126 838 0
Fos K562GSE19551 114441027 114441261 234 0
FoxA1 MCF7MACSdata 114282561 114282898 337 0
FoxA1 MCF7MACSdata 114321921 114322188 267 0
NRSF mAbJurkat 114322007 114324516 2509 0
NRSF-mono JurkatQuESTdata 114321867 114322203 336 0
NRSF-poly JurkatQuESTdata 114321928 114322310 382 0
Nanog hESGSE18292 114410895 114411941 1046 0
Oct1 H2O2-HelaGSE14283 114233388 114233425 37 0
Oct1 H2O2-HelaGSE14283 114419262 114419290 28 0
Oct1 H2O2-HelaGSE14283 114461870 114461916 46 0
Oct1 H2O2-HelaGSE14283 114482126 114482160 34 0
Oct1 H2O2-HelaGSE14283 114517714 114517752 38 0
Oct1 HelaGSE14283 114233388 114233423 35 0
Oct1 HelaGSE14283 114327810 114327855 45 0
Oct1 HelaGSE14283 114358374 114358449 75 0
Oct1 HelaGSE14283 114367793 114367825 32 0
Oct1 HelaGSE14283 114382439 114382470 31 0
Oct1 HelaGSE14283 114436255 114436284 29 0
Oct1 HelaGSE14283 114461869 114461903 34 0
Oct1 HelaGSE14283 114482125 114482163 38 0
Oct1 HelaGSE14283 114517715 114517752 37 0
Oct4 hESGSE17917 114204853 114205271 418 0
P300 T30-glioblastomaGSE21026 114282249 114282976 727 0
RNAII Tamoxifen-MCF7GSE14664 114384411 114384502 91 0
RNAII Tamoxifen-MCF7GSE14664 114436247 114436284 37 0
RNAII Tamoxifen-MCF7GSE14664 114446015 114446108 93 0
hScc1 BcellGSE12603 114235363 114235765 402 0
hScc1 BcellGSE12603 114354637 114354965 328 0
hScc1 BcellGSE12603 114418930 114419262 332 0
hScc1 CdLSGSE12603 114418712 114419303 591 0
hScc1 G2GSE9613 114235400 114235876 476 0
hScc1 G2GSE9613 114418824 114419262 438 0
hScc1 G2GSE9613 114499242 114499999 757 0
p130 QuiescentGSE19898 114433976 114434183 207 0
p130 QuiescentGSE19898 114441191 114441435 244 0
p130 SenescentGSE19898 114433305 114434290 985 0
p130 shRbQuiescentGSE19898 114432781 114433760 979 0
p130 shRbSenescentGSE19898 114441184 114441485 301 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-122 hsa-mir-122 18 19296470
hsa-miR-122* hsa-mir-122 18 19296470
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
20092 mRNA ANK2 chr4 114328473 114662489 2911 EST chr4 114493019 114495930 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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