AutismKB 2.0

Annotation Detail for MKNK2


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Basic Information Top
Gene Symbol:MKNK2 ( GPRK7,MNK2 )
Gene Full Name: MAP kinase interacting serine/threonine kinase 2
Band: 19p13.3
Quick LinksEntrez ID:2872; OMIM: 605069; Uniprot ID:MKNK2_HUMAN; ENSEMBL ID: ENSG00000099875; HGNC ID: 7111
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
244Phosphothreonine.
249Phosphothreonine.
379Phosphothreonine.
452Phosphoserine.
Location(AA) Modifications Resource
244Phosphothreonine.Swiss-Prot 53.0
249Phosphothreonine.Swiss-Prot 53.0
379Phosphothreonine.Swiss-Prot 53.0
Location(AA) Modification Resource
51Phosphoserine(ATM)HMM predict
72Phosphothreonine(PKA)HMM predict
156Phosphotyrosine(Syk)HMM predict
220Phosphoserine(CDC2)HMM predict
220Phosphoserine(CDK)HMM predict
244Phosphothreonine(CDK)HMM predict
249PhosphothreonineHMM predict
256Phosphotyrosine(SRC)HMM predict
256Phosphotyrosine(Syk)HMM predict
256Phosphotyrosine(INSR)HMM predict
266Phosphoserine(CK2)HMM predict
266Phosphoserine(CK1)HMM predict
327Phosphotyrosine(SRC)HMM predict
430Phosphothreonine(PKA)HMM predict
431Phosphoserine(PKA)HMM predict
440Phosphoserine(ATM)HMM predict
452Phosphoserine(PKG)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_017572
  • Location:chr19 1988469-2002232
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF JurkatGSE12889 2002305 2002447 142 144
HIF1 NormHepG2 2001845 2002675 830 28
NFkBII GM10847GSE19485 2006087 2007341 1254 4482
NFkBII GM12878GSE19485 2001802 2004082 2280 710
NFkBII GM12878GSE19485 2005928 2007468 1540 4466
NFkBII GM12892GSE19485 2001803 2003937 2134 638
NFkBII GM12892GSE19485 2005690 2008208 2518 4717
NFkBII GM15510GSE19485 2000638 2004067 3429 120
NFkBII GM15510GSE19485 2005952 2007859 1907 4673
NFkBII GM18505GSE19485 2005996 2007174 1178 4353
NFkBII GM18526GSE19485 2000453 2004062 3609 25
NFkBII GM18526GSE19485 2005942 2007360 1418 4419
PHF8 Hs68minusFBSGSE20725 2007300 2007969 669 5402
TFAP2C MCF7GSE21234 2010309 2011405 1096 8625
hScc1 BcellGSE12603 2001535 2003238 1703 154
hScc1 BcellGSE12603 2007870 2008129 259 5767
p130 QuiescentGSE19898 2007455 2007720 265 5355
p130 shRbQuiescentGSE19898 2007203 2007701 498 5220
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog hESGSE18292 1979874 1980104 230 8481
Pol2 GM12878GSE19551 1988147 1988598 451 97
Rb QuiescentGSE19898 1986449 1986589 140 1951
STAT1 HeLaGSE12782 1978079 1980490 2411 9185
STAT1 HeLaGSE12783 1978157 1979277 1120 9753
STAT1 IFNSISSRdata 1978461 1979026 565 9726
TFAP2C MCF7GSE21234 1979710 1980130 420 8550
VDR GM10861-stimGSE22484 1982704 1983725 1021 5255
hScc1 BcellGSE12603 1984840 1985041 201 3529
hScc1 BcellGSE12603 1985751 1986653 902 2268
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 2001429 2002575 1146 0
Fos K562GSE19551 1992850 1993644 794 0
FoxA1 MCF7MACSdata 2000781 2000935 154 0
NFkBII GM10847GSE19485 1992320 1993793 1473 0
NFkBII GM12878GSE19485 1991980 1993673 1693 0
NFkBII GM12892GSE19485 1991760 1993845 2085 0
NFkBII GM15510GSE19485 1992278 1993955 1677 0
Oct4 hESGSE21916 1992781 1994151 1370 0
P300 T30-glioblastomaGSE21026 2000491 2002631 2140 0
TFAP2C MCF7GSE21234 2000505 2001241 736 0
VDR GM10861-UnstimGSE22484 1999870 2004058 4188 0
VDR GM10861-stimGSE22484 1987241 1990026 2785 0
hScc1 BcellGSE12603 1997182 1997420 238 0
hScc1 BcellGSE12603 2000083 2000412 329 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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