AutismKB 2.0

Annotation Detail for GRN


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Basic Information Top
Gene Symbol:GRN ( GEP,GP88,PCDGF,PEPI,PGRN )
Gene Full Name: granulin
Band: 17q21.31
Quick LinksEntrez ID:2896; OMIM: 138945; Uniprot ID:GRN_HUMAN; ENSEMBL ID: ENSG00000030582; HGNC ID: 4601
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
118N-linked (GlcNAc...) (Potential).
236N-linked (GlcNAc...) (Potential).
265N-linked (GlcNAc...).
368N-linked (GlcNAc...).
530N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
118N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
236N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
265N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
368N-linked (GlcNAc...).Swiss-Prot 53.0
530N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
40Phosphoserine(IKK)HMM predict
99S-palmitoylHMM predict
236N-linkedHMM predict
262Phosphoserine(CK1)HMM predict
265N-linkedHMM predict
368N-linkedHMM predict
435Phosphoserine(PKG)HMM predict
435Phosphoserine(CAMK2)HMM predict
530N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002087
  • Location:chr17 39778016-39785995
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 39776446 39776791 345 1398
TAF HelaGSE8489 39777820 39778033 213 90
TFAP2C MCF7GSE21234 39777753 39778276 523 2
USF1 HepG2E 39776194 39777280 1086 1280
USF2 HepG2E 39776194 39777280 1086 1280
hScc1 BcellGSE12603 39776477 39777004 527 1276
hScc1 BcellGSE12603 39777820 39778112 292 51
p130 QuiescentGSE19898 39777754 39778150 396 65
p130 shRbSenescentGSE19898 39777801 39778204 403 14
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 39786621 39787956 1335 1293
CTCF G2GSE9613 39789084 39789412 328 3253
hScc1 BcellGSE12603 39786085 39786756 671 425
hScc1 BcellGSE12603 39793742 39794014 272 7883
hScc1 CdLSGSE12603 39787464 39787956 492 1715
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 39783750 39784040 290 0
CTCF CD4SISSRdata 39783750 39784040 290 0
CTCF HelaGSE12889 39783626 39783919 293 0
CTCF JurkatGSE12889 39783713 39783941 228 0
CTCF G2GSE9613 39783602 39784002 400 0
ETS1 JurkatGSE17954 39777577 39779144 1567 0
Fos K562GSE19551 39777759 39778373 614 0
PHF8 293TGSE20725 39778067 39778854 787 0
Rb SenescentGSE19898 39777813 39778382 569 0
USF1 HepG2E 39777820 39778887 1067 0
USF2 HepG2E 39777820 39778597 777 0
hScc1 BcellGSE12603 39778771 39779237 466 0
hScc1 BcellGSE12603 39783440 39784069 629 0
hScc1 CdLSGSE12603 39778658 39779189 531 0
hScc1 CdLSGSE12603 39783674 39784069 395 0
p130 SenescentGSE19898 39777738 39778351 613 0
p130 shRbQuiescentGSE19898 39777692 39778373 681 0
p130 SGSE7516 39777820 39778423 603 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-107 hsa-mir-107 10 20884628
hsa-miR-107 hsa-mir-107 10 20489155
hsa-miR-15a hsa-mir-15a 13 20884628
hsa-miR-15a* hsa-mir-15a 13 20884628
hsa-miR-15b hsa-mir-15b 3 20884628
hsa-miR-15b* hsa-mir-15b 3 20884628
hsa-miR-16 hsa-mir-16-1 13 20884628
hsa-miR-16 hsa-mir-16-2 3 20884628
hsa-miR-195 hsa-mir-195 17 20884628
hsa-miR-195* hsa-mir-195 17 20884628
hsa-miR-29b hsa-mir-29b-1 7 20479936
hsa-miR-29b hsa-mir-29b-2 1 20479936
hsa-miR-29b-1* hsa-mir-29b-1 7 20479936
hsa-miR-29b-2* hsa-mir-29b-2 1 20479936
hsa-miR-659 hsa-mir-659 22 18723524
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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