AutismKB 2.0

Annotation Detail for GRIK1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GRIK1 ( EAA3,EEA3,GLR5,GLUR5 )
Gene Full Name: glutamate receptor, ionotropic, kainate 1
Band: 21q21.3
Quick LinksEntrez ID:2897; OMIM: 138245; Uniprot ID:GRIK1_HUMAN; ENSEMBL ID: ENSG00000171189; HGNC ID: 4579
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
68N-linked (GlcNAc...) (Potential).
74N-linked (GlcNAc...) (Potential).
276N-linked (GlcNAc...) (Potential).
379N-linked (GlcNAc...) (Potential).
428N-linked (GlcNAc...) (Potential).
439N-linked (GlcNAc...) (Potential).
446N-linked (GlcNAc...) (Potential).
561N-linked (GlcNAc...) (Potential).
725Phosphoserine; by PKC (Potential).
761Phosphothreonine; by PKC (Potential).
Location(AA) Modifications Resource
68N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
74N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
276N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
379N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
428N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
439N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
446N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
561N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
725Phosphoserine (by PKC) (Potential).Swiss-Prot 53.0
761Phosphothreonine (by PKC) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
18Phosphoserine(CAMK2)HMM predict
18Phosphoserine(IKK)HMM predict
68N-linkedHMM predict
74N-linkedHMM predict
115Phosphoserine(CK1)HMM predict
115O-linkedHMM predict
117Phosphoserine(IKK)HMM predict
147Phosphotyrosine(INSR)HMM predict
276N-linkedHMM predict
339Phosphoserine(PKG)HMM predict
379N-linkedHMM predict
382N-linkedHMM predict
428N-linkedHMM predict
433N-linkedHMM predict
439N-linkedHMM predict
446N-linkedHMM predict
561N-linkedHMM predict
564N-linkedHMM predict
620N-linkedHMM predict
625N-linkedHMM predict
712Phosphoserine(PKC)HMM predict
766N-linkedHMM predict
779Phosphotyrosine(INSR)HMM predict
886N-linkedHMM predict
887O-linkedHMM predict
888O-linkedHMM predict
889O-linkedHMM predict
891O-linkedHMM predict
892O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000830
  • Location:chr21 29847736-30234152
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TAF HelaGSE8489 30251847 30252021 174 17782
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 29950848 29951489 641 0
CTCF CD4GSE12889 30143989 30144315 326 0
CTCF CD4SISSRdata 30143989 30144315 326 0
CTCF G2GSE9613 30143737 30144275 538 0
Fos K562GSE19551 29950672 29951440 768 0
Fos K562GSE19551 30168050 30168453 403 0
Gata2 K562GSE18868 29935868 29937839 1971 0
Nanog hESGSE18292 29910482 29910903 421 0
Nanog hESGSE18292 30080796 30081367 571 0
Nanog hESGSE18292 30211512 30211901 389 0
Oct4 hESGSE17917 30144022 30144276 254 0
P300 T30-glioblastomaGSE21026 29950500 29951407 907 0
TAF k562GSE8489 30207936 30208155 219 0
hScc1 BcellGSE12603 29895676 29895903 227 0
hScc1 BcellGSE12603 30143863 30144275 412 0
hScc1 BcellGSE12603 30233135 30233778 643 0
hScc1 CdLSGSE12603 30143486 30144541 1055 0
hScc1 G2GSE9613 30143669 30144458 789 0
p63 keratinocytesGSE17611 30208263 30209130 867 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
16823 EST chr21 29831391 29832097 130 EST GRIK1 chr21 29831124 29831521Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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