AutismKB 2.0

Annotation Detail for GRIK2


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Basic Information Top
Gene Symbol:GRIK2 ( EAA4,GLR6,GLUK6,GLUR6,MGC74427,MRT6 )
Gene Full Name: glutamate receptor, ionotropic, kainate 2
Band: 6q16.3
Quick LinksEntrez ID:2898; OMIM: 138244; Uniprot ID:GRIK2_HUMAN; ENSEMBL ID: ENSG00000164418; HGNC ID: 4580
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
67N-linked (GlcNAc...) (Potential).
73N-linked (GlcNAc...) (Potential).
275N-linked (GlcNAc...) (Potential).
378N-linked (GlcNAc...) (Potential).
412N-linked (GlcNAc...) (Potential).
423N-linked (GlcNAc...) (Potential).
430N-linked (GlcNAc...) (Potential).
546N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
67N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
73N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
275N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
378N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
412N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
423N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
430N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
546N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
697Phosphoserine (PKA
715Phosphoserine (PKA
Location(AA) Modification Resource
67N-linkedHMM predict
73N-linkedHMM predict
146Phosphotyrosine(INSR)HMM predict
146Phosphotyrosine(EGFR)HMM predict
251SulfotyrosineHMM predict
254SulfotyrosineHMM predict
275N-linkedHMM predict
341Phosphothreonine(PKC)HMM predict
378N-linkedHMM predict
381N-linkedHMM predict
412N-linkedHMM predict
416Phosphoserine(ATM)HMM predict
423N-linkedHMM predict
430N-linkedHMM predict
546N-linkedHMM predict
549N-linkedHMM predict
605N-linkedHMM predict
610N-linkedHMM predict
697Phosphoserine(PKC)HMM predict
715Phosphoserine(PKG)HMM predict
715Phosphoserine(PKA)HMM predict
751N-linkedHMM predict
764Phosphotyrosine(INSR)HMM predict
809Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_175768
  • Location:chr6 101953674-102623473
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 101947963 101948592 629 5397
H3K27me3 colorectalcancer 101945896 101946274 378 7590
H3K27me3 colorectalcancer 101946632 101948151 1519 6283
NRSF JurkatGSE13047 101950813 101952127 1314 2205
NRSF mAbJurkat 101948700 101956125 7425 1262
NRSF-mono JurkatQuESTdata 101950934 101951899 965 2258
NRSF-poly JurkatQuESTdata 101950970 101951595 625 2392
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 102277473 102278294 821 0
CTCF G2GSE9613 101956920 101957186 266 0
CTCF G2GSE9613 101975617 101975841 224 0
ER E2-MCF7GSE14664 102000192 102000228 36 0
ER E2-MCF7GSE14664 102038144 102038185 41 0
ER E2-MCF7GSE14664 102060236 102060269 33 0
ER E2-MCF7GSE14664 102426199 102426235 36 0
FoxA1 MCF7MACSdata 102163326 102163564 238 0
H3K27me3 colorectalcancer 101954441 101956093 1652 0
Nanog ESGSE20650 102169339 102169936 597 0
Nanog ESGSE20650 102271001 102271946 945 0
Nanog hESGSE18292 102236725 102237118 393 0
Nanog hESGSE18292 102271383 102272001 618 0
Oct1 H2O2-HelaGSE14283 102120518 102120554 36 0
Oct1 H2O2-HelaGSE14283 102249002 102249034 32 0
Oct1 H2O2-HelaGSE14283 102367240 102367275 35 0
Oct1 H2O2-HelaGSE14283 102390902 102390939 37 0
Oct1 H2O2-HelaGSE14283 102394888 102394923 35 0
Oct1 H2O2-HelaGSE14283 102435266 102435304 38 0
Oct1 H2O2-HelaGSE14283 102446454 102446504 50 0
Oct1 H2O2-HelaGSE14283 102522099 102522129 30 0
Oct1 HelaGSE14283 102000204 102000239 35 0
Oct1 HelaGSE14283 102034726 102034756 30 0
Oct1 HelaGSE14283 102058358 102058392 34 0
Oct1 HelaGSE14283 102060231 102060265 34 0
Oct1 HelaGSE14283 102200267 102200320 53 0
Oct1 HelaGSE14283 102221710 102221750 40 0
Oct1 HelaGSE14283 102240869 102240897 28 0
Oct1 HelaGSE14283 102249001 102249033 32 0
Oct1 HelaGSE14283 102390859 102390939 80 0
Oct1 HelaGSE14283 102394892 102394921 29 0
Oct1 HelaGSE14283 102426205 102426241 36 0
Oct1 HelaGSE14283 102435265 102435302 37 0
Oct1 HelaGSE14283 102442706 102442738 32 0
Oct1 HelaGSE14283 102446454 102446504 50 0
Oct1 HelaGSE14283 102493829 102493862 33 0
Oct1 HelaGSE14283 102520483 102520520 37 0
Oct4 hESGSE21916 102271332 102271811 479 0
P300 T30-glioblastomaGSE21026 102277231 102278424 1193 0
Sox2 hESGSE18292 102271457 102272008 551 0
USF1 HepG2E 102130366 102130874 508 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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