Annotation Detail for GRIK2

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Basic Information Top

Gene Symbol:	GRIK2 ( EAA4,GLR6,GLUK6,GLUR6,MGC74427,MRT6 )
Gene Full Name:	glutamate receptor, ionotropic, kainate 2
Band:	6q16.3
Quick Links	Entrez ID:2898; OMIM: 138244; Uniprot ID:GRIK2_HUMAN; ENSEMBL ID: ENSG00000164418; HGNC ID: 4580
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:8 results
Experimental PTM Sites from dbPTM:10 results
Predicted PTM Sites by profile HMM from dbPTM:24 results

Location(AA)	Modification
67	N-linked (GlcNAc...) (Potential).
73	N-linked (GlcNAc...) (Potential).
275	N-linked (GlcNAc...) (Potential).
378	N-linked (GlcNAc...) (Potential).
412	N-linked (GlcNAc...) (Potential).
423	N-linked (GlcNAc...) (Potential).
430	N-linked (GlcNAc...) (Potential).
546	N-linked (GlcNAc...) (Potential).

Location(AA)	Modifications	Resource
67	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
73	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
275	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
378	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
412	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
423	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
430	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
546	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
697	Phosphoserine (PKA
715	Phosphoserine (PKA

Location(AA)	Modification	Resource
67	N-linked	HMM predict
73	N-linked	HMM predict
146	Phosphotyrosine(INSR)	HMM predict
146	Phosphotyrosine(EGFR)	HMM predict
251	Sulfotyrosine	HMM predict
254	Sulfotyrosine	HMM predict
275	N-linked	HMM predict
341	Phosphothreonine(PKC)	HMM predict
378	N-linked	HMM predict
381	N-linked	HMM predict
412	N-linked	HMM predict
416	Phosphoserine(ATM)	HMM predict
423	N-linked	HMM predict
430	N-linked	HMM predict
546	N-linked	HMM predict
549	N-linked	HMM predict
605	N-linked	HMM predict
610	N-linked	HMM predict
697	Phosphoserine(PKC)	HMM predict
715	Phosphoserine(PKG)	HMM predict
715	Phosphoserine(PKA)	HMM predict
751	N-linked	HMM predict
764	Phosphotyrosine(INSR)	HMM predict
809	Phosphoserine(CK1)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_175768
Location:chr6 101953674-102623473
strand:+

Upstream the gene:7 results
Downstream the gene:0 results
Inside the gene:41 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	101947963	101948592	629	5397
H3K27me3	colorectal	cancer	101945896	101946274	378	7590
H3K27me3	colorectal	cancer	101946632	101948151	1519	6283
NRSF	Jurkat	GSE13047	101950813	101952127	1314	2205
NRSF	mAb	Jurkat	101948700	101956125	7425	1262
NRSF-mono	Jurkat	QuESTdata	101950934	101951899	965	2258
NRSF-poly	Jurkat	QuESTdata	101950970	101951595	625	2392

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CBP	T30-glioblastoma	GSE21026	102277473	102278294	821
CTCF	G2	GSE9613	101956920	101957186	266
CTCF	G2	GSE9613	101975617	101975841	224
ER	E2-MCF7	GSE14664	102000192	102000228	36
ER	E2-MCF7	GSE14664	102038144	102038185	41
ER	E2-MCF7	GSE14664	102060236	102060269	33
ER	E2-MCF7	GSE14664	102426199	102426235	36
FoxA1	MCF7	MACSdata	102163326	102163564	238
H3K27me3	colorectal	cancer	101954441	101956093	1652
Nanog	ES	GSE20650	102169339	102169936	597
Nanog	ES	GSE20650	102271001	102271946	945
Nanog	hES	GSE18292	102236725	102237118	393
Nanog	hES	GSE18292	102271383	102272001	618
Oct1	H2O2-Hela	GSE14283	102120518	102120554	36
Oct1	H2O2-Hela	GSE14283	102249002	102249034	32
Oct1	H2O2-Hela	GSE14283	102367240	102367275	35
Oct1	H2O2-Hela	GSE14283	102390902	102390939	37
Oct1	H2O2-Hela	GSE14283	102394888	102394923	35
Oct1	H2O2-Hela	GSE14283	102435266	102435304	38
Oct1	H2O2-Hela	GSE14283	102446454	102446504	50
Oct1	H2O2-Hela	GSE14283	102522099	102522129	30
Oct1	Hela	GSE14283	102000204	102000239	35
Oct1	Hela	GSE14283	102034726	102034756	30
Oct1	Hela	GSE14283	102058358	102058392	34
Oct1	Hela	GSE14283	102060231	102060265	34
Oct1	Hela	GSE14283	102200267	102200320	53
Oct1	Hela	GSE14283	102221710	102221750	40
Oct1	Hela	GSE14283	102240869	102240897	28
Oct1	Hela	GSE14283	102249001	102249033	32
Oct1	Hela	GSE14283	102390859	102390939	80
Oct1	Hela	GSE14283	102394892	102394921	29
Oct1	Hela	GSE14283	102426205	102426241	36
Oct1	Hela	GSE14283	102435265	102435302	37
Oct1	Hela	GSE14283	102442706	102442738	32
Oct1	Hela	GSE14283	102446454	102446504	50
Oct1	Hela	GSE14283	102493829	102493862	33
Oct1	Hela	GSE14283	102520483	102520520	37
Oct4	hES	GSE21916	102271332	102271811	479
P300	T30-glioblastoma	GSE21026	102277231	102278424	1193
Sox2	hES	GSE18292	102271457	102272008	551
USF1	HepG2	E	102130366	102130874	508

Validated miRNA targets

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Cis-Nats regulation

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Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for GRIK2

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics