AutismKB 2.0

Annotation Detail for HIPK2


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Basic Information Top
Gene Symbol:HIPK2 ( DKFZp686K02111,FLJ23711,PRO0593 )
Gene Full Name: homeodomain interacting protein kinase 2
Band: 7q34
Quick LinksEntrez ID:28996; OMIM: 606868; Uniprot ID:HIPK2_HUMAN; ENSEMBL ID: ENSG00000064393; HGNC ID: 14402
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
361Phosphotyrosine.
827Phosphoserine.
838Phosphothreonine.
Location(AA) Modifications Resource
32Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
1191Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
60O-linkedHMM predict
60Phosphoserine(ATM)HMM predict
64O-linkedHMM predict
65O-linkedHMM predict
66O-linkedHMM predict
68O-linkedHMM predict
68O-linkedHMM predict
69O-linkedHMM predict
70O-linkedHMM predict
75N-linkedHMM predict
96O-linkedHMM predict
99O-linkedHMM predict
99O-linkedHMM predict
100O-linkedHMM predict
100O-linkedHMM predict
101O-linkedHMM predict
102O-linkedHMM predict
102Phosphoserine(CK1)HMM predict
102Phosphoserine(IKK)HMM predict
118Phosphoserine(PKA)HMM predict
118Phosphoserine(PKG)HMM predict
119Phosphothreonine(PKA)HMM predict
121Phosphoserine(IKK)HMM predict
140N-linkedHMM predict
157N-linkedHMM predict
162O-linkedHMM predict
165O-linkedHMM predict
168O-linkedHMM predict
169O-linkedHMM predict
169Phosphoserine(IKK)HMM predict
170O-linkedHMM predict
172O-linkedHMM predict
173O-linkedHMM predict
180Phosphoserine(CK2)HMM predict
184Phosphotyrosine(SRC)HMM predict
184SulfotyrosineHMM predict
199Phosphotyrosine(SRC)HMM predict
251Phosphoserine(PKG)HMM predict
271N-linkedHMM predict
294Phosphoserine(CDC2)HMM predict
354O-linkedHMM predict
367Phosphotyrosine(EGFR)HMM predict
414Phosphoserine(ATM)HMM predict
480N-linkedHMM predict
562N-linkedHMM predict
575O-linkedHMM predict
579N-linkedHMM predict
581O-linkedHMM predict
585N-linkedHMM predict
599O-linkedHMM predict
600Phosphoserine(IKK)HMM predict
602O-linkedHMM predict
797Phosphoserine(IKK)HMM predict
804Phosphoserine(CK1)HMM predict
810Phosphoserine(PKA)HMM predict
813N-linkedHMM predict
822O-linkedHMM predict
822Phosphoserine(ATM)HMM predict
822Phosphoserine(IKK)HMM predict
827Phosphoserine(CDC2)HMM predict
827Phosphoserine(CDK)HMM predict
838Phosphothreonine(MAPK)HMM predict
848O-linkedHMM predict
866Phosphothreonine(PKC)HMM predict
880O-linkedHMM predict
880Phosphothreonine(MAPK)HMM predict
882Phosphoserine(CDC2)HMM predict
882Phosphoserine(MAPK)HMM predict
884O-linkedHMM predict
906O-linkedHMM predict
924Phosphoserine(ATM)HMM predict
927Phosphoserine(CK2)HMM predict
931Phosphoserine(CK1)HMM predict
931Phosphoserine(IKK)HMM predict
932N-linkedHMM predict
933O-linkedHMM predict
934Phosphoserine(CDC2)HMM predict
990N-linkedHMM predict
1004Phosphoserine(IKK)HMM predict
1005N-linkedHMM predict
1007O-linkedHMM predict
1008O-linkedHMM predict
1008Phosphoserine(CK1)HMM predict
1010Phosphoserine(CK2)HMM predict
1014O-linkedHMM predict
1016Phosphoserine(CK1)HMM predict
1018O-linkedHMM predict
1018Phosphoserine(IKK)HMM predict
1065O-linkedHMM predict
1071Phosphotyrosine(Abl)HMM predict
1077PhosphoserineHMM predict
1079O-linkedHMM predict
1103Phosphotyrosine(Abl)HMM predict
1113O-linkedHMM predict
1130Phosphothreonine(PKC)HMM predict
1155O-linkedHMM predict
1155Phosphoserine(CDC2)HMM predict
1161Phosphoserine(ATM)HMM predict
1172Phosphotyrosine(Jak)HMM predict
1174O-linkedHMM predict
1176O-linkedHMM predict
1176Phosphoserine(CDC2)HMM predict
1179O-linkedHMM predict
1179O-linkedHMM predict
1188Phosphoserine(CDC2)HMM predict
1193AsparagineHMM predict
1197TyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_022740
  • Location:chr7 138907920-138967013
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 138981271 138981534 263 14389
CTCF CD4SISSRdata 138981271 138981534 263 14389
CTCF G2GSE9613 138977696 138977935 239 10802
CTCF G2GSE9613 138980644 138981438 794 14028
ER MCF7GSE19013 138985920 138987047 1127 19470
Oct1 HelaGSE14283 138971486 138971519 33 4489
Oct1 HelaGSE14283 138974781 138974859 78 7807
hScc1 BcellGSE12603 138980998 138981438 440 14205
hScc1 BcellGSE12603 138981825 138982144 319 14971
hScc1 CdLSGSE12603 138981041 138981438 397 14226
hScc1 CdLSGSE12603 138983786 138984781 995 17270
hScc1 G2GSE9613 138980847 138981438 591 14129
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF JurkatGSE12889 138893606 138893813 207 14211
CTCF G2GSE9613 138894716 138895321 605 12902
CTCF G2GSE9613 138896152 138896441 289 11624
CTCF G2GSE9613 138897853 138898530 677 9729
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 138917050 138920254 3204 0
CTCF CD4GSE12889 138956241 138956471 230 0
CTCF CD4SISSRdata 138956241 138956471 230 0
CTCF G2GSE9613 138908320 138908698 378 0
CTCF G2GSE9613 138910453 138910747 294 0
CTCF G2GSE9613 138917574 138917896 322 0
CTCF G2GSE9613 138937553 138937768 215 0
CTCF G2GSE9613 138953922 138954519 597 0
CTCF G2GSE9613 138955670 138956625 955 0
CTCF G2GSE9613 138961085 138961306 221 0
Myc hESGSE17917 138954083 138954365 282 0
Oct1 HelaGSE14283 138940153 138940214 61 0
Rb GrowingGSE19898 138956511 138956706 195 0
Sox2 hESGSE18292 138937492 138937761 269 0
Stat6 IL-4-hr1GSE17850 138961730 138962652 922 0
hScc1 BcellGSE12603 138937553 138937803 250 0
hScc1 BcellGSE12603 138955936 138956589 653 0
hScc1 CdLSGSE12603 138937553 138938000 447 0
hScc1 CdLSGSE12603 138954103 138954909 806 0
hScc1 CdLSGSE12603 138955936 138956625 689 0
hScc1 G2GSE9613 138937553 138937768 215 0
hScc1 G2GSE9613 138955857 138956373 516 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-181a hsa-mir-181a-2 9 21274007
hsa-miR-181a hsa-mir-181a-1 1 21274007
hsa-miR-27a hsa-mir-27a 19 20646448
hsa-miR-27a hsa-mir-27a 19 20624637
hsa-miR-27a* hsa-mir-27a 19 20646448
hsa-miR-27a* hsa-mir-27a 19 20624637
hsa-miR-374a hsa-mir-374a X 21274007
hsa-miR-374a* hsa-mir-374a X 21274007
hsa-miR-519a hsa-mir-519a-1 19 21274007
hsa-miR-519a hsa-mir-519a-2 19 21274007
hsa-miR-630 hsa-mir-630 15 21274007
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
24715 EST chr7 138756117 138757849 1732 mRNA HIPK2 chr7 138714635 138773729 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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