AutismKB 2.0

Annotation Detail for GRIN2B


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Basic Information Top
Gene Symbol:GRIN2B ( MGC142178,MGC142180,NMDAR2B,NR2B,hNR3 )
Gene Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Band: 12p13.1
Quick LinksEntrez ID:2904; OMIM: 138252; Uniprot ID:NMDE2_HUMAN; ENSEMBL ID: ENSG00000150086; HGNC ID: 4586
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
74N-linked (GlcNAc...) (Potential).
341N-linked (GlcNAc...) (Potential).
348N-linked (GlcNAc...) (Potential).
444N-linked (GlcNAc...) (Potential).
491N-linked (GlcNAc...) (Potential).
542N-linked (GlcNAc...) (Potential).
688N-linked (GlcNAc...) (Potential).
917Phosphoserine (By similarity).
930Phosphoserine (By similarity).
932Phosphotyrosine (By similarity).
949Phosphotyrosine (By similarity).
962Phosphotyrosine (By similarity).
1039Phosphotyrosine (By similarity).
1049Phosphotyrosine (By similarity).
1061Phosphoserine (By similarity).
1065Phosphothreonine (By similarity).
1070Phosphotyrosine (By similarity).
1109Phosphotyrosine (By similarity).
1155Phosphotyrosine (By similarity).
1166Phosphoserine (By similarity).
1252Phosphotyrosine (By similarity).
1303Phosphoserine (By similarity).
1304Phosphotyrosine (By similarity).
1474Phosphotyrosine (By similarity).
1484PDZ-binding (By similarity).
Location(AA) Modifications Resource
74N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
341N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
348N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
444N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
491N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
542N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
688N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
917Phosphoserine (By similarity).Swiss-Prot 53.0
1166Phosphoserine (By similarity).Swiss-Prot 53.0
1303Phosphoserine (By similarity).Swiss-Prot 53.0
1303Phosphoserine (PKC alpha)Phospho.ELM 6.0
1323Phosphoserine (PKC alpha)Phospho.ELM 6.0
1474Phosphotyrosine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
28Phosphoserine(PKG)HMM predict
28Phosphoserine(CAMK2)HMM predict
28Phosphoserine(ATM)HMM predict
28Phosphoserine(IKK)HMM predict
31Phosphoserine(IKK)HMM predict
74N-linkedHMM predict
173O-linkedHMM predict
239Phosphotyrosine(SRC)HMM predict
260O-linkedHMM predict
341N-linkedHMM predict
356Phosphotyrosine(Syk)HMM predict
356Phosphotyrosine(EGFR)HMM predict
433Phosphothreonine(PKA)HMM predict
444N-linkedHMM predict
452Phosphotyrosine(EGFR)HMM predict
479Phosphotyrosine(Jak)HMM predict
491N-linkedHMM predict
495N-linkedHMM predict
542N-linkedHMM predict
615N-linkedHMM predict
616N-linkedHMM predict
626Phosphothreonine(PKC)HMM predict
688N-linkedHMM predict
694N-linkedHMM predict
699Phosphotyrosine(INSR)HMM predict
811Phosphoserine(ATM)HMM predict
869Phosphotyrosine(INSR)HMM predict
886Phosphoserine(CDK)HMM predict
886Phosphoserine(CDC2)HMM predict
886Phosphoserine(IKK)HMM predict
892N-linkedHMM predict
893N-linkedHMM predict
897N-linkedHMM predict
910N-linkedHMM predict
915N-linkedHMM predict
917Phosphoserine(CDC2)HMM predict
929Phosphoserine(PKG)HMM predict
929Phosphoserine(PKA)HMM predict
930PhosphoserineHMM predict
962Phosphotyrosine(INSR)HMM predict
981Phosphotyrosine(Syk)HMM predict
981Phosphotyrosine(EGFR)HMM predict
1019Phosphoserine(PKG)HMM predict
1033Phosphoserine(ATM)HMM predict
1033Phosphoserine(IKK)HMM predict
1050PhosphoserineHMM predict
1050Phosphoserine(CK1)HMM predict
1116Phosphoserine(CDK)HMM predict
1116Phosphoserine(CDC2)HMM predict
1116Phosphoserine(ATM)HMM predict
1133Phosphotyrosine(Syk)HMM predict
1155Phosphotyrosine(Syk)HMM predict
1175N-linkedHMM predict
1200N-linkedHMM predict
1203N-linkedHMM predict
1224N-linkedHMM predict
1225Phosphotyrosine(INSR)HMM predict
1242S-palmitoylHMM predict
1259Phosphoserine(CK1)HMM predict
1274O-linkedHMM predict
1274O-linkedHMM predict
1275N-linkedHMM predict
1278O-linkedHMM predict
1279O-linkedHMM predict
1284Phosphoserine(CDC2)HMM predict
1303Phosphoserine(CAMK2)HMM predict
1352N-linkedHMM predict
1450N-linkedHMM predict
1453N-linkedHMM predict
1466N-linkedHMM predict
1470N-linkedHMM predict
1479Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000834
  • Location:chr12 13605410-14024318
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 14024660 14025341 681 682
CTCF G2GSE9613 14025921 14026573 652 1929
FOXA1 DLD1GSE12801 14036838 14037152 314 12677
H3K27me3 colorectalcancer 14025317 14025921 604 1301
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 DLD1GSE12801 13603481 13604069 588 1636
hScc1 CdLSGSE12603 13588858 13589292 434 16336
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 13705575 13705762 187 0
CTCF CD4GSE12889 13908364 13908672 308 0
CTCF CD4SISSRdata 13705575 13705762 187 0
CTCF CD4SISSRdata 13908364 13908672 308 0
CTCF JurkatGSE12889 13908395 13908668 273 0
CTCF JurkatGSE12889 14006995 14007189 194 0
CTCF G2GSE9613 13606714 13606913 199 0
CTCF G2GSE9613 13607210 13607968 758 0
CTCF G2GSE9613 13608271 13608816 545 0
CTCF G2GSE9613 13671082 13671249 167 0
CTCF G2GSE9613 13705474 13705803 329 0
CTCF G2GSE9613 13783727 13784228 501 0
CTCF G2GSE9613 13788911 13789054 143 0
CTCF G2GSE9613 13875513 13875753 240 0
CTCF G2GSE9613 13908363 13908842 479 0
CTCF G2GSE9613 13910213 13910500 287 0
CTCF G2GSE9613 13924108 13924395 287 0
CTCF G2GSE9613 13956766 13957123 357 0
CTCF G2GSE9613 13985782 13986334 552 0
CTCF G2GSE9613 14007605 14007949 344 0
CTCF G2GSE9613 14011816 14011955 139 0
ER Fulvestrant-MCF7GSE14664 13712184 13712310 126 0
FOXA1 DLD1GSE12801 13672696 13673576 880 0
FOXA1 DLD1GSE12801 13922779 13922996 217 0
FOXA1 MCF7GSE15244 13686513 13686881 368 0
Myc K562GSE19551 13908389 13908620 231 0
NRSF JurkatGSE13047 13845659 13846283 624 0
NRSF JurkatSISSRdata 13622425 13622564 139 0
NRSF JurkatSISSRdata 13845847 13846006 159 0
NRSF-mono JurkatQuESTdata 13845729 13846191 462 0
NRSF-poly JurkatQuESTdata 13845775 13846160 385 0
Nanog hESGSE18292 13793508 13794142 634 0
Nanog hESGSE18292 13843576 13844210 634 0
Nanog hESGSE18292 13985454 13985924 470 0
Oct1 H2O2-HelaGSE14283 13756579 13756609 30 0
Oct1 H2O2-HelaGSE14283 13783193 13783224 31 0
Oct1 H2O2-HelaGSE14283 14006346 14006382 36 0
Oct1 HelaGSE14283 13712185 13712315 130 0
Oct1 HelaGSE14283 13783193 13783224 31 0
Oct1 HelaGSE14283 13805583 13805646 63 0
Oct1 HelaGSE14283 14006346 14006381 35 0
Oct4 hESGSE17917 13670993 13671154 161 0
Oct4 hESGSE17917 13896139 13896553 414 0
Sox2 hESGSE18292 13985291 13985856 565 0
hScc1 BcellGSE12603 13705439 13705803 364 0
hScc1 BcellGSE12603 13908325 13908842 517 0
hScc1 CdLSGSE12603 13705370 13705803 433 0
hScc1 CdLSGSE12603 13908286 13909249 963 0
hScc1 CdLSGSE12603 13985782 13986403 621 0
hScc1 G2GSE9613 13705557 13705803 246 0
hScc1 G2GSE9613 13908363 13908708 345 0
hScc1 G2GSE9613 13985782 13986334 552 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-132 hsa-mir-132 17 19958814
hsa-miR-132* hsa-mir-132 17 19958814
hsa-miR-9 hsa-mir-9-1 1 19958814
hsa-miR-9 hsa-mir-9-2 5 19958814
hsa-miR-9 hsa-mir-9-3 15 19958814
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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