AutismKB 2.0

Annotation Detail for NR3C1


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Basic Information Top
Gene Symbol:NR3C1 ( GCCR,GCR,GR,GRL )
Gene Full Name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Band: 5q31.3
Quick LinksEntrez ID:2908; OMIM: 138040; Uniprot ID:GCR_HUMAN; ENSEMBL ID: ENSG00000113580; HGNC ID: 7978
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
8Phosphothreonine.
45Phosphoserine.
113Phosphoserine (By similarity).
134Phosphoserine.
141Phosphoserine (By similarity).
203Phosphoserine.
211Phosphoserine.
226Phosphoserine.
234Phosphoserine.
267Phosphoserine.
Location(AA) Modifications Resource
113Phosphoserine (By similarity).Swiss-Prot 53.0
113PhosphoserinePhospho.ELM 6.0
141Phosphoserine (By similarity).Swiss-Prot 53.0
141PhosphoserinePhospho.ELM 6.0
203Phosphoserine.Swiss-Prot 53.0
203PhosphoserinePhospho.ELM 6.0
211Phosphoserine.Swiss-Prot 53.0
211PhosphoserinePhospho.ELM 6.0
226Phosphoserine (By similarity).Swiss-Prot 53.0
226Phosphoserine (MAPK
277Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
293Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
508Phosphoserine (DNA-PK)Phospho.ELM 6.0
Location(AA) Modification Resource
8Phosphothreonine(MAPK)HMM predict
42Phosphoserine(PKG)HMM predict
44O-linkedHMM predict
47O-linkedHMM predict
71Phosphoserine(IKK)HMM predict
130N-linkedHMM predict
134Phosphoserine(IKK)HMM predict
134Phosphoserine(CK1)HMM predict
141Phosphoserine(IKK)HMM predict
142O-linkedHMM predict
144O-linkedHMM predict
148O-linkedHMM predict
164Phosphoserine(CK1)HMM predict
165Phosphoserine(CK1)HMM predict
203Phosphoserine(CDC2)HMM predict
203PhosphoserineHMM predict
209N-linkedHMM predict
211PhosphoserineHMM predict
226Phosphoserine(MAPK)HMM predict
266Phosphoserine(CK1)HMM predict
267Phosphoserine(CDC2)HMM predict
270N-linkedHMM predict
278Phosphothreonine(CK2)HMM predict
327Phosphoserine(IKK)HMM predict
342Phosphoserine(ATM)HMM predict
374N-linkedHMM predict
393Phosphotyrosine(INSR)HMM predict
393Phosphotyrosine(Abl)HMM predict
393Phosphotyrosine(Jak)HMM predict
394Phosphoserine(INSR)HMM predict
395Phosphoserine(CDK)HMM predict
395Phosphoserine(CDC2)HMM predict
403O-linkedHMM predict
407O-linkedHMM predict
407O-linkedHMM predict
408O-linkedHMM predict
410Phosphoserine(IKK)HMM predict
411O-linkedHMM predict
413O-linkedHMM predict
413O-linkedHMM predict
455Phosphotyrosine(INSR)HMM predict
493Phosphothreonine(PKC)HMM predict
517N-linkedHMM predict
551Phosphoserine(ATM)HMM predict
635Phosphothreonine(PKA)HMM predict
663Phosphotyrosine(Jak)HMM predict
663Phosphotyrosine(INSR)HMM predict
663Phosphotyrosine(Syk)HMM predict
707N-linkedHMM predict
709Phosphoserine(ATM)HMM predict
711N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001018074
  • Location:chr5 142637688-142795269
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 142801313 142801340 27 6057
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 142777376 142777419 43 0
ETS1 JurkatGSE17954 142764176 142765782 1606 0
FOXA1 MCF7GSE15244 142777442 142778519 1077 0
H3ac HepG2E 142764509 142764979 470 0
NFkBII GM12878GSE19485 142777169 142779118 1949 0
Oct1 HelaGSE14283 142768085 142768145 60 0
Oct1 HelaGSE14283 142768696 142768734 38 0
Oct1 HelaGSE14283 142777385 142777420 35 0
P300 T0-glioblastomaGSE21026 142764302 142765926 1624 0
P300 T30-glioblastomaGSE21026 142762830 142765897 3067 0
RARA MCF7GSE15244 142777486 142778519 1033 0
TAF HelaGSE8489 142765081 142765913 832 0
hScc1 CdLSGSE12603 142773936 142774559 623 0
hScc1 CdLSGSE12603 142794465 142795512 1047 0
p130 QuiescentGSE19898 142764911 142765545 634 0
p130 SenescentGSE19898 142764179 142765734 1555 0
p130 shRbQuiescentGSE19898 142764845 142765668 823 0
p130 shRbSenescentGSE19898 142765132 142765757 625 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-124 hsa-mir-124-1 8 19131573
hsa-miR-124 hsa-mir-124-2 8 19131573
hsa-miR-124 hsa-mir-124-3 20 19131573
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
21608 EST chr5 142644689 142645109 420 mRNA NR3C1 chr5 142639324 142763087 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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