AutismKB 2.0

Annotation Detail for TBK1


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Basic Information Top
Gene Symbol:TBK1 ( FLJ11330,NAK,T2K )
Gene Full Name: TANK-binding kinase 1
Band: 12q14.2
Quick LinksEntrez ID:29110; OMIM: 604834; Uniprot ID:TBK1_HUMAN; ENSEMBL ID: ENSG00000183735; HGNC ID: 11584
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
172Phosphoserine; by autocatalysis.
509Phosphoserine.
510Phosphoserine.
716Phosphoserine.
Location(AA) Modifications Resource
172Phosphoserine (by autocatalysis).Swiss-Prot 53.0
172PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
31Phosphothreonine(PKA)HMM predict
78Phosphothreonine(PKC)HMM predict
105Phosphotyrosine(SRC)HMM predict
105Phosphotyrosine(INSR)HMM predict
179Phosphotyrosine(Syk)HMM predict
179Phosphotyrosine(Jak)HMM predict
185Phosphotyrosine(EGFR)HMM predict
325SulfotyrosineHMM predict
454Phosphotyrosine(EGFR)HMM predict
455N-linkedHMM predict
509Phosphoserine(CK1)HMM predict
511Phosphoserine(ATM)HMM predict
527Phosphoserine(MAPK)HMM predict
527Phosphoserine(CDC2)HMM predict
614N-linkedHMM predict
645Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_013254
  • Location:chr12 63132203-63182157
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
HIF1 HypoHepG2 63131850 63132244 394 157
USF1 HepG2E 63130507 63131974 1467 963
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 63193310 63193336 26 11166
Oct1 H2O2-HelaGSE14283 63198387 63198420 33 16246
Oct1 HelaGSE14283 63198376 63198420 44 16241
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 63131765 63132657 892 0
H3K4me3 colorectalcancer 63132585 63133186 601 0
H3ac HepG2E 63132621 63134001 1380 0
Oct1 H2O2-HelaGSE14283 63181341 63181387 46 0
Oct1 HelaGSE14283 63174532 63174572 40 0
Oct1 HelaGSE14283 63181341 63181383 42 0
Oct1 HelaGSE14283 63181906 63181932 26 0
PHF8 HeLaGSE20725 63131624 63132859 1235 0
PHF8 Hs68plusFBSGSE20725 63131396 63133363 1967 0
RARA MCF7GSE15244 63132732 63133155 423 0
TAF HelaGSE8489 63132512 63133423 911 0
TAF k562GSE8489 63132512 63134244 1732 0
USF1 HepG2E 63132585 63133788 1203 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7c hsa-let-7c 21 20018759
hsa-let-7c* hsa-let-7c 21 20018759
hsa-miR-21 hsa-mir-21 17 20018759
hsa-miR-21* hsa-mir-21 17 20018759
hsa-miR-211 hsa-mir-211 15 20018759
hsa-miR-221 hsa-mir-221 X 20018759
hsa-miR-221* hsa-mir-221 X 20018759
hsa-miR-222 hsa-mir-222 X 20018759
hsa-miR-222* hsa-mir-222 X 20018759
hsa-miR-34a hsa-mir-34a 1 20018759
hsa-miR-34a* hsa-mir-34a 1 20018759
hsa-miR-519a hsa-mir-519a-1 19 20018759
hsa-miR-519a hsa-mir-519a-2 19 20018759
hsa-miR-93 hsa-mir-93 7 20018759
hsa-miR-93* hsa-mir-93 7 20018759
hsa-miR-96 hsa-mir-96 7 20018759
hsa-miR-96* hsa-mir-96 7 20018759
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
6229 mRNA TBK1 chr12 63132203 63182158 31 mRNA TBK1 chr12 63131638 63132948Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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