AutismKB 2.0

Annotation Detail for GSK3B


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Basic Information Top
Gene Symbol:GSK3B ( - )
Gene Full Name: glycogen synthase kinase 3 beta
Band: 3q13.33
Quick LinksEntrez ID:2932; OMIM: 605004; Uniprot ID:GSK3B_HUMAN; ENSEMBL ID: ENSG00000082701; HGNC ID: 4617
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
7Phosphothreonine.
9Phosphoserine; by PKB/AKT1.
25Phosphoserine.
215Phosphoserine.
216Phosphotyrosine.
219Phosphoserine.
275Phosphothreonine.
277Phosphothreonine.
389Phosphoserine.
390Phosphothreonine.
392Phosphothreonine.
395Phosphothreonine (By similarity).
398Phosphoserine.
413Phosphoserine.
415Phosphoserine.
417Phosphoserine.
419Phosphoserine.
Location(AA) Modifications Resource
7Phosphothreonine (By similarity).Swiss-Prot 53.0
9Phosphoserine (by PKB/AKT1).Swiss-Prot 53.0
9Phosphoserine (PKA
21Phosphoserine (SGK
43Phosphothreonine (MAPK1;MAPK3)Phospho.ELM 6.0
215Phosphoserine (By similarity).Swiss-Prot 53.0
216Phosphotyrosine (MAP2K1)Phospho.ELM 6.0
216Phosphotyrosine.Swiss-Prot 53.0
219Phosphoserine (By similarity).Swiss-Prot 53.0
389Phosphoserine (By similarity).Swiss-Prot 53.0
390Phosphothreonine.Swiss-Prot 53.0
395Phosphothreonine (By similarity).Swiss-Prot 53.0
402PhosphothreoninePhospho.ELM 6.0
Location(AA) Modification Resource
7Phosphothreonine(PKC)HMM predict
9Phosphoserine(IKK)HMM predict
9Phosphoserine(PKA)HMM predict
9Phosphoserine(PKB)HMM predict
29Phosphoserine(PKG)HMM predict
39O-linkedHMM predict
43O-linkedHMM predict
140Phosphotyrosine(SRC)HMM predict
275Phosphothreonine(MAPK)HMM predict
287N-linkedHMM predict
288SulfotyrosineHMM predict
309PhosphothreonineHMM predict
309Phosphothreonine(MAPK)HMM predict
330Phosphothreonine(MAPK)HMM predict
330Phosphothreonine(CDK)HMM predict
338Phosphoserine(CK2)HMM predict
361N-linkedHMM predict
390Phosphothreonine(MAPK)HMM predict
392O-linkedHMM predict
393N-linkedHMM predict
395O-linkedHMM predict
415Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002093
  • Location:chr3 121028237-121295202
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 121295470 121296938 1468 1002
ER MCF7GSE19013 121299905 121300713 808 5107
FOXA1 MCF7GSE15244 121296074 121296710 636 1190
FOXA1 MCF7GSE15244 121297220 121297733 513 2274
FOXA1 MCF7GSE15244 121300361 121300628 267 5292
H3K4me3 colorectalcancer 121297304 121297733 429 2316
H3ac HepG2E 121297220 121297733 513 2274
Oct1 H2O2-HelaGSE14283 121304975 121305003 28 9787
Oct1 HelaGSE14283 121296577 121296607 30 1390
Oct1 HelaGSE14283 121304974 121305012 38 9791
Oct1 HelaGSE14283 121311739 121311769 30 16552
PHF8 HeLaGSE20725 121295324 121296250 926 585
PHF8 HeLaGSE20725 121296333 121297757 1424 1843
RARA MCF7GSE15244 121297220 121297733 513 2274
RARA MCF7GSE15244 121300295 121300694 399 5292
RARG MCF7GSE15244 121297220 121297733 513 2274
TAF k562GSE8489 121297413 121297733 320 2371
hScc1 BcellGSE12603 121295548 121297261 1713 1202
hScc1 CdLSGSE12603 121297121 121297733 612 2225
hScc1 G2GSE9613 121295585 121297595 2010 1388
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 121093451 121093892 441 0
CTCF CD4SISSRdata 121093451 121093892 441 0
CTCF G2GSE9613 121085513 121085872 359 0
CTCF G2GSE9613 121093491 121093860 369 0
ER Fulvestrant-MCF7GSE14664 121245789 121245821 32 0
FOXA1 MCF7GSE15244 121043462 121043695 233 0
FOXA1 MCF7GSE15244 121085295 121085906 611 0
FOXA1 MCF7GSE15244 121093491 121094087 596 0
FOXA1 MCF7GSE15244 121214930 121215342 412 0
FoxA1 MCF7MACSdata 121128135 121128279 144 0
FoxA1 MCF7MACSdata 121174891 121175156 265 0
H3K4me3 colorectalcancer 121293151 121295036 1885 0
H3ac HepG2E 121290202 121290871 669 0
H3ac HepG2E 121291630 121292746 1116 0
H3ac HepG2E 121293039 121293766 727 0
H3ac HepG2E 121294015 121295315 1300 0
NRSF JurkatGSE13047 121263903 121264583 680 0
NRSF mAbJurkat 121260626 121261955 1329 0
NRSF mAbJurkat 121263581 121264940 1359 0
NRSF-mono JurkatQuESTdata 121263902 121264482 580 0
NRSF-poly JurkatQuESTdata 121263988 121264454 466 0
Nanog hESGSE18292 121114408 121115064 656 0
Oct1 H2O2-HelaGSE14283 121154685 121154713 28 0
Oct1 H2O2-HelaGSE14283 121215058 121215098 40 0
Oct1 HelaGSE14283 121116020 121116060 40 0
Oct1 HelaGSE14283 121154685 121154717 32 0
Oct1 HelaGSE14283 121215059 121215098 39 0
Oct1 HelaGSE14283 121241837 121241906 69 0
Oct1 HelaGSE14283 121241923 121241990 67 0
Oct1 HelaGSE14283 121291571 121291670 99 0
Oct1 HelaGSE14283 121291778 121291858 80 0
RARA MCF7GSE15244 121043047 121043770 723 0
RARA MCF7GSE15244 121044762 121044969 207 0
RARA MCF7GSE15244 121085295 121085906 611 0
RARG MCF7GSE15244 121085476 121085906 430 0
RNAII Tamoxifen-MCF7GSE14664 121291561 121291623 62 0
Sox2 hESGSE18292 121114555 121114842 287 0
Stat6 IL-4-hr4GSE17850 121028332 121028858 526 0
TFAP2C MCF7GSE21234 121033705 121034172 467 0
TFAP2C MCF7GSE21234 121043251 121043846 595 0
TFAP2C MCF7GSE21234 121174832 121175231 399 0
hScc1 BcellGSE12603 121093389 121093908 519 0
hScc1 CdLSGSE12603 121093275 121094197 922 0
hScc1 G2GSE9613 121093458 121094051 593 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-26a hsa-mir-26a-1 3 20525681
hsa-miR-26a hsa-mir-26a-2 12 20525681
hsa-miR-26a-1* hsa-mir-26a-1 3 20525681
hsa-miR-26a-2* hsa-mir-26a-2 12 20525681
hsa-miR-26b hsa-mir-26b 2 20525681
hsa-miR-26b* hsa-mir-26b 2 20525681
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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