AutismKB 2.0

Annotation Detail for GSN


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Basic Information Top
Gene Symbol:GSN ( DKFZp313L0718 )
Gene Full Name: gelsolin
Band: 9q33.2
Quick LinksEntrez ID:2934; OMIM: 137350; Uniprot ID:GELS_HUMAN; ENSEMBL ID: ENSG00000148180; HGNC ID: 4620
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
86Phosphotyrosine; by SRC; in vitro.
409Phosphotyrosine; by SRC; in vitro.
465Phosphotyrosine; by SRC.
603Phosphotyrosine; by SRC; in vitro.
651Phosphotyrosine; by SRC; in vitro.
Location(AA) Modifications Resource
86Phosphotyrosine; by SRC; in vitro.Swiss-Prot 53.0
409Phosphotyrosine; by SRC; in vitro.Swiss-Prot 53.0
465Phosphotyrosine (by SRC).Swiss-Prot 53.0
465Phosphotyrosine (Src)Phospho.ELM 6.0
603Phosphotyrosine; by SRC; in vitro.Swiss-Prot 53.0
651Phosphotyrosine; by SRC; in vitro.Swiss-Prot 53.0
Location(AA) Modification Resource
31O-linkedHMM predict
32MethylarginineHMM predict
121Phosphoserine(ATM)HMM predict
430O-linkedHMM predict
465Phosphotyrosine(EGFR)HMM predict
499Phosphothreonine(PKC)HMM predict
499Phosphothreonine(CK2)HMM predict
651Phosphotyrosine(EGFR)HMM predict
653Phosphothreonine(PKC)HMM predict
654Phosphoserine(MAPK)HMM predict
715Phosphoserine(CK2)HMM predict
742Phosphothreonine(PKA)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000177
  • Location:chr9 123101899-123134940
  • strand:+
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
STAT1 HeLaGSE12783 123135858 123139491 3633 2734
TFAP2C MCF7GSE21234 123136282 123137919 1637 2160
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 123122155 123122480 325 0
CTCF CD4SISSRdata 123122155 123122480 325 0
ER E2-MCF7GSE14664 123108531 123108638 107 0
ER Fulvestrant-MCF7GSE14664 123125685 123125729 44 0
Fos K562GSE19551 123122029 123122547 518 0
H3ac HepG2E 123102243 123102839 596 0
Myc K562GSE19551 123122085 123122541 456 0
Oct1 H2O2-HelaGSE14283 123125685 123125716 31 0
Oct1 HelaGSE14283 123125684 123125718 34 0
Oct4 hESGSE17917 123122295 123122543 248 0
P300 T0-glioblastomaGSE21026 123124308 123125226 918 0
P300 T30-glioblastomaGSE21026 123124043 123125172 1129 0
Rb shRbSenescenceGSE19898 123122149 123122377 228 0
STAT1 HeLaGSE12783 123124029 123125626 1597 0
TAFII hESGSE17917 123122238 123122575 337 0
TFAP2C MCF7GSE21234 123128181 123128698 517 0
hScc1 BcellGSE12603 123110936 123111128 192 0
hScc1 BcellGSE12603 123122099 123122420 321 0
hScc1 CdLSGSE12603 123121828 123122420 592 0
hScc1 G2GSE9613 123121142 123122420 1278 0
p130 QuiescentGSE19898 123122302 123122444 142 0
p63 keratinocytesGSE17611 123124198 123125172 974 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
388 Unknown MicroArray miR-124 GSN n_a 15685193
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000148180 G1-to-S transition n_a n_a "epithelium, lymphoblast, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
26986 mRNA GSN chr9 121109960 121174674 93 mRNA MOST2 chr9 121122599 121127362Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018