AutismKB 2.0

Annotation Detail for EEF2K


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:EEF2K ( HSU93850,MGC45041,eEF-2K )
Gene Full Name: eukaryotic elongation factor-2 kinase
Band: 16p12.2
Quick LinksEntrez ID:29904; OMIM: 606968; Uniprot ID:EF2K_HUMAN; ENSEMBL ID: ENSG00000103319; HGNC ID: 24615
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
18Phosphoserine.
27Phosphoserine.
31Phosphoserine.
69Phosphotyrosine.
70Phosphoserine.
71Phosphoserine (By similarity).
135Phosphoserine.
348Phosphothreonine.
445Phosphoserine.
470Phosphoserine.
474Phosphoserine.
477Phosphoserine.
Location(AA) Modifications Resource
18Phosphoserine.Swiss-Prot 53.0
18PhosphoserinePhospho.ELM 6.0
27Phosphoserine.Swiss-Prot 53.0
31Phosphoserine.Swiss-Prot 53.0
69Phosphotyrosine.Swiss-Prot 53.0
70Phosphoserine.Swiss-Prot 53.0
71Phosphoserine (By similarity).Swiss-Prot 53.0
78Phosphoserine (AMPK
359Phosphoserine (MAPK13)Phospho.ELM 6.0
366Phosphoserine (AMPK
377Phosphoserine (MAPKAPK2)Phospho.ELM 6.0
396Phosphoserine (eEF2K)Phospho.ELM 6.0
398Phosphoserine (AMPK
445Phosphoserine.Swiss-Prot 53.0
470Phosphoserine.Swiss-Prot 53.0
470PhosphoserinePhospho.ELM 6.0
474Phosphoserine.Swiss-Prot 53.0
474PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
20MethylarginineHMM predict
31Phosphoserine(CK2)HMM predict
62N-linkedHMM predict
70Phosphoserine(IKK)HMM predict
70Phosphoserine(CK1)HMM predict
72O-linkedHMM predict
74Phosphoserine(IKK)HMM predict
74Phosphoserine(CDC2)HMM predict
113Phosphothreonine(PKC)HMM predict
282Phosphotyrosine(INSR)HMM predict
282Phosphotyrosine(Abl)HMM predict
359Phosphoserine(CDC2)HMM predict
380Phosphoserine(CK1)HMM predict
380Phosphoserine(CK2)HMM predict
384N-linkedHMM predict
395Phosphoserine(CK1)HMM predict
395O-linkedHMM predict
396Phosphoserine(CDC2)HMM predict
396Phosphoserine(ATM)HMM predict
396Phosphoserine(CDK)HMM predict
398O-linkedHMM predict
398Phosphoserine(IKK)HMM predict
399O-linkedHMM predict
438Phosphoserine(CK1)HMM predict
438PhosphoserineHMM predict
443Phosphotyrosine(INSR)HMM predict
468SulfotyrosineHMM predict
470Phosphoserine(CK2)HMM predict
474Phosphoserine(IKK)HMM predict
474Phosphoserine(CK1)HMM predict
490N-linkedHMM predict
575Phosphoserine(ATM)HMM predict
593N-linkedHMM predict
625N-linkedHMM predict
656Phosphotyrosine(INSR)HMM predict
656Phosphotyrosine(Abl)HMM predict
656SulfotyrosineHMM predict
665Phosphotyrosine(INSR)HMM predict
693Phosphotyrosine(INSR)HMM predict
713Phosphotyrosine(Syk)HMM predict
713Phosphotyrosine(EGFR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_013302
  • Location:chr16 22125092-22207565
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 22114669 22115055 386 10231
CTCF CD4SISSRdata 22114669 22115055 386 10231
CTCF G2GSE9613 22107410 22107915 505 17430
CTCF G2GSE9613 22114704 22115143 439 10169
Fos K562GSE19551 22114257 22115102 845 10413
H3ac HepG2E 22107485 22108842 1357 16929
KLF4 hESGSE17917 22114498 22114767 269 10460
Oct1 H2O2-HelaGSE14283 22115083 22115116 33 9993
PHF8 Hs68minusFBSGSE20725 22114093 22114990 897 10551
PHF8 Hs68plusFBSGSE20725 22114118 22115281 1163 10393
Pol3 GM12878GSE19551 22114324 22115091 767 10385
Pol3 K562GSE19551 22114219 22114778 559 10594
Rb GrowingGSE19898 22109742 22109991 249 15226
Rb QuiescentGSE19898 22109680 22109960 280 15273
Rb SenescentGSE19898 22109166 22110492 1326 15264
Rb shRbSenescenceGSE19898 22109677 22109995 318 15257
TFAP2C MCF7GSE21234 22120522 22121008 486 4328
USF1 HepG2E 22108118 22108658 540 16705
USF1 HepG2E 22109619 22111964 2345 14301
USF1 HepG2E 22112282 22113130 848 12387
USF1 HepG2E 22120488 22120790 302 4454
USF1 HepG2E 22124366 22125082 716 369
USF2 HepG2E 22110662 22111964 1302 13780
hScc1 BcellGSE12603 22107410 22107915 505 17430
hScc1 BcellGSE12603 22109010 22109550 540 15813
hScc1 BcellGSE12603 22114668 22115306 638 10106
hScc1 BcellGSE12603 22124655 22125510 855 10
hScc1 CdLSGSE12603 22107132 22107849 717 17602
hScc1 CdLSGSE12603 22114403 22115342 939 10220
hScc1 CdLSGSE12603 22124366 22125720 1354 50
p130 SenescentGSE19898 22109686 22110071 385 15214
p130 shRbQuiescentGSE19898 22110136 22110481 345 14784
p130 shRbSenescentGSE19898 22118385 22118709 324 6546
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TAF HelaGSE8489 22211425 22211717 292 4006
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 22124707 22125680 973 0
CTCF G2GSE9613 22139568 22139712 144 0
CTCF G2GSE9613 22167201 22167378 177 0
FOXA1 MCF7GSE15244 22151353 22151991 638 0
Fos K562GSE19551 22151307 22151587 280 0
Fos K562GSE19551 22174098 22174537 439 0
H3K4me3 colorectalcancer 22126720 22127022 302 0
H3ac HepG2E 22125542 22127022 1480 0
NFkBII GM10847GSE19485 22124349 22126522 2173 0
Nanog hESGSE18292 22143968 22144373 405 0
Oct1 H2O2-HelaGSE14283 22130481 22130524 43 0
Oct1 H2O2-HelaGSE14283 22153913 22153949 36 0
Oct1 H2O2-HelaGSE14283 22167645 22167683 38 0
Oct1 H2O2-HelaGSE14283 22173087 22173120 33 0
Oct1 H2O2-HelaGSE14283 22176337 22176365 28 0
Oct1 HelaGSE14283 22130481 22130524 43 0
Oct1 HelaGSE14283 22140105 22140150 45 0
Oct1 HelaGSE14283 22153916 22153947 31 0
Oct1 HelaGSE14283 22167644 22167682 38 0
Oct1 HelaGSE14283 22198483 22198532 49 0
PHF8 HeLaGSE20725 22124913 22126243 1330 0
RARA MCF7GSE15244 22151353 22152157 804 0
RNAII Tamoxifen-MCF7GSE14664 22198483 22198524 41 0
TAF HelaGSE8489 22151353 22151600 247 0
TFAP2C MCF7GSE21234 22151198 22152292 1094 0
TFAP2C MCF7GSE21234 22183517 22184044 527 0
USF1 HepG2E 22126498 22127022 524 0
USF1 HepG2E 22129502 22129732 230 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
9726 mRNA EEF2K chr16 22125256 22205452 372 EST chr16 22125099 22203445Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved