AutismKB 2.0

Annotation Detail for ANXA2


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Basic Information Top
Gene Symbol:ANXA2 ( ANX2,ANX2L4,CAL1H,LIP2,LPC2,LPC2D,P36,PAP-IV )
Gene Full Name: annexin A2
Band: 15q22.2
Quick LinksEntrez ID:302; OMIM: 151740; Uniprot ID:ANXA2_HUMAN; ENSEMBL ID: ENSG00000182718; HGNC ID: 537
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylserine.
18Phosphoserine.
19Phosphothreonine.
24Phosphotyrosine; by SRC.
26Phosphoserine; by PKC.
30Phosphotyrosine.
104N6-acetyllysine.
115N6-acetyllysine.
148N6-acetyllysine.
152N6-acetyllysine.
157N6-acetyllysine.
188Phosphotyrosine.
199Phosphotyrosine.
227N6-acetyllysine.
238Phosphotyrosine.
275Phosphotyrosine.
279N6-acetyllysine.
302N6-acetyllysine.
313N6-acetyllysine.
316Phosphotyrosine.
317Phosphotyrosine.
318Phosphotyrosine.
Location(AA) Modifications Resource
2N-acetylserine (By similarity).Swiss-Prot 53.0
2PhosphothreoninePhospho.ELM 6.0
11PhosphoserinePhospho.ELM 6.0
17PhosphoserinePhospho.ELM 6.0
18PhosphothreoninePhospho.ELM 6.0
18Phosphoserine.Swiss-Prot 53.0
19Phosphothreonine.Swiss-Prot 53.0
23Phosphotyrosine (Src)Phospho.ELM 6.0
24Phosphotyrosine (by SRC).Swiss-Prot 53.0
25Phosphoserine (PKC alpha;PK)Phospho.ELM 6.0
26Phosphoserine (by PKC).Swiss-Prot 53.0
29PhosphotyrosinePhospho.ELM 6.0
30Phosphotyrosine.Swiss-Prot 53.0
Location(AA) Modification Resource
18Phosphoserine(IKK)HMM predict
19Phosphothreonine(CDK)HMM predict
19Phosphothreonine(CDC2)HMM predict
24Phosphotyrosine(SRC)HMM predict
62N-linkedHMM predict
65N-linkedHMM predict
92Phosphoserine(CK2)HMM predict
127Phosphoserine(CK1)HMM predict
208Phosphothreonine(PKA)HMM predict
234Phosphoserine(PKG)HMM predict
238Phosphotyrosine(Syk)HMM predict
283Phosphothreonine(PKC)HMM predict
296Phosphoserine(IKK)HMM predict
318SulfotyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001002857
  • Location:chr15 58426643-58477476
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 58483834 58483866 32 6374
H3ac HepG2E 58478749 58479808 1059 1802
H3ac HepG2E 58481901 58482655 754 4802
P300 T0-glioblastomaGSE21026 58487678 58488648 970 10687
TAF HelaGSE8489 58477682 58478206 524 468
TAF HelaGSE8489 58478749 58479296 547 1546
TAF k562GSE8489 58478749 58479220 471 1508
hScc1 BcellGSE12603 58477066 58478244 1178 179
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 58439191 58439470 279 0
CTCF CD4SISSRdata 58439191 58439470 279 0
CTCF G2GSE9613 58438972 58439440 468 0
CTCF G2GSE9613 58477186 58477463 277 0
ER E2-MCF7GSE14664 58468092 58468144 52 0
ER Fulvestrant-MCF7GSE14664 58468108 58468184 76 0
ER Fulvestrant-MCF7GSE14664 58472789 58472820 31 0
ER MCF7GSE19013 58472422 58472984 562 0
FOXA1 MCF7GSE15244 58453857 58454642 785 0
FOXA1 MCF7GSE15244 58472090 58473192 1102 0
FOXA1 eGFPGSE10845 58453857 58454642 785 0
FOXA1 eGFPGSE10845 58472090 58473192 1102 0
FoxA1 MCF7MACSdata 58454127 58454433 306 0
H3K4me2 HCT116GSE10453 58476017 58476451 434 0
H3K4me3 colorectalcancer 58475979 58476379 400 0
H3ac HepG2E 58455896 58456270 374 0
H3ac HepG2E 58469024 58469430 406 0
H3ac HepG2E 58470844 58471367 523 0
H3ac HepG2E 58472346 58473873 1527 0
Myc K562GSE19551 58442235 58442559 324 0
Nanog ESGSE20650 58447621 58447752 131 0
Nanog hESGSE18292 58470457 58471034 577 0
Oct1 HelaGSE14283 58472764 58472825 61 0
P300 T30-glioblastomaGSE21026 58458727 58459954 1227 0
PHF8 HeLaGSE20725 58475784 58478584 2800 0
RARA MCF7GSE15244 58453752 58454465 713 0
RARA MCF7GSE15244 58458804 58459590 786 0
RARA MCF7GSE15244 58471972 58473225 1253 0
Rb GrowingGSE19898 58433136 58433269 133 0
Rb GrowingGSE19898 58459000 58459188 188 0
TFAP2C MCF7GSE21234 58453899 58454584 685 0
TFAP2C MCF7GSE21234 58458941 58459728 787 0
TFAP2C MCF7GSE21234 58470549 58471160 611 0
TFAP2C MCF7GSE21234 58474009 58474491 482 0
hScc1 BcellGSE12603 58438612 58439440 828 0
hScc1 BcellGSE12603 58456089 58456446 357 0
hScc1 BcellGSE12603 58459251 58459590 339 0
hScc1 CdLSGSE12603 58438934 58439440 506 0
p130 shRbSenescentGSE19898 58459234 58459669 435 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1129 Unknown pSILAC miR-1 ANXA2 down 75-50% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000182718 n_a n_a n_a "epithelium, squamous cell, lymphocyte, leukocyte, macrophage" "benign tumour, malignant tumour, carcinoma, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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