Annotation Detail for HARS

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Basic Information Top

Gene Symbol:	HARS ( FLJ20491,HRS )
Gene Full Name:	histidyl-tRNA synthetase
Band:	5q31.3
Quick Links	Entrez ID:3035; OMIM: 142810; Uniprot ID:SYHC_HUMAN; ENSEMBL ID: ENSG00000170445; HGNC ID: 4816
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
2	N-acetylalanine.
443	N6-acetyllysine.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
ETS1	Jurkat	GSE17954	140050642	140051711	1069	22

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	140050878	140051386	508
ER	E2-MCF7	GSE14664	140041735	140041782	47
ER	Fulvestrant-MCF7	GSE14664	140041741	140041781	40
GABP	k562	GSE8489	140049476	140049913	437
GABP	k562	GSE8489	140050252	140051594	1342
H3K4me3	colorectal	cancer	140050252	140050722	470
H3ac	HepG2	E	140050252	140050972	720
Oct1	Hela	GSE14283	140037777	140037827	50
PHF8	Hs68plusFBS	GSE20725	140050117	140051910	1793
Rb	Growing	GSE19898	140039226	140039441	215
hScc1	Bcell	GSE12603	140050569	140051077	508
p130	shRbQuiescent	GSE19898	140050584	140051454	870

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
1048	Unknown	pSILAC	miR-16	HARS	down 50-25%	18668040
1049	Unknown	pSILAC	miR-16	HARS	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000170445		n_a	n_a	n_a	"epithelium, lymphocyte"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000170445		n_a	n_a	n_a	"epithelium, lymphocyte"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018