AutismKB 2.0

Annotation Detail for HCK


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HCK ( JTK9 )
Gene Full Name: hemopoietic cell kinase
Band: 20q11.21
Quick LinksEntrez ID:3055; OMIM: 142370; Uniprot ID:HCK_HUMAN; ENSEMBL ID: ENSG00000101336; HGNC ID: 4840
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
36Phosphothreonine.
51Phosphotyrosine.
127Phosphotyrosine.
202Phosphothreonine.
209Phosphotyrosine.
330Phosphotyrosine.
411Phosphotyrosine; by autocatalysis (By
462Phosphoserine.
515Phosphotyrosine.
520Phosphoserine.
522Phosphotyrosine.
Location(AA) Modifications Resource
2N-myristoyl glycine (By similarity).Swiss-Prot 53.0
208Phosphotyrosine (HCK)Phospho.ELM 6.0
410Phosphotyrosine (HCK)Phospho.ELM 6.0
411Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
521Phosphotyrosine (HCK)Phospho.ELM 6.0
Location(AA) Modification Resource
40PhosphothreonineHMM predict
43O-linkedHMM predict
56O-linkedHMM predict
57O-linkedHMM predict
58O-linkedHMM predict
111Phosphoserine(CK1)HMM predict
122Phosphothreonine(PKC)HMM predict
127Phosphotyrosine(INSR)HMM predict
127Phosphotyrosine(EGFR)HMM predict
138Phosphoserine(CK1)HMM predict
147MethyllysineHMM predict
152MethyllysineHMM predict
209Phosphotyrosine(INSR)HMM predict
211Phosphoserine(CDC2)HMM predict
330Phosphotyrosine(Jak)HMM predict
330Phosphotyrosine(EGFR)HMM predict
411Phosphotyrosine(INSR)HMM predict
411Phosphotyrosine(Syk)HMM predict
411Phosphotyrosine(Jak)HMM predict
411PhosphotyrosineHMM predict
506Phosphotyrosine(Jak)HMM predict
515Phosphotyrosine(Jak)HMM predict
515Phosphotyrosine(Syk)HMM predict
520Phosphoserine(ATM)HMM predict
522Phosphotyrosine(SRC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002110
  • Location:chr20 30103717-30153315
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K27me3 colorectalcancer 30098685 30099230 545 4760
H3K27me3 colorectalcancer 30102461 30103438 977 768
Stat6 IL-4-hr1GSE17850 30097887 30098351 464 5599
TFAP2C MCF7GSE21234 30103448 30103923 475 32
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 30160874 30160995 121 7619
CTCF CD4SISSRdata 30160874 30160995 121 7619
ETS1 JurkatGSE17954 30160367 30161908 1541 7822
H3K4me3 colorectalcancer 30162085 30162503 418 8979
H3ac HepG2E 30160497 30163554 3057 8710
H3ac HepG2E 30164196 30164625 429 11095
P300 T0-glioblastomaGSE21026 30160580 30161758 1178 7854
P300 T30-glioblastomaGSE21026 30160313 30162994 2681 8338
PHF8 293TGSE20725 30160733 30161764 1031 7933
TAF HelaGSE8489 30160454 30163554 3100 8689
USF1 HepG2E 30160497 30162503 2006 8185
USF2 HepG2E 30160568 30161763 1195 7850
hScc1 BcellGSE12603 30161392 30161824 432 8293
hScc1 BcellGSE12603 30164196 30164411 215 10988
p130 QuiescentGSE19898 30160823 30161896 1073 8044
p130 shRbQuiescentGSE19898 30160793 30161849 1056 8006
p130 shRbSenescentGSE19898 30160839 30161686 847 7947
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 30105941 30106157 216 0
CTCF CD4GSE12889 30143410 30143626 216 0
CTCF CD4SISSRdata 30143410 30143626 216 0
CTCF G2GSE9613 30143569 30143950 381 0
P300 T0-glioblastomaGSE21026 30105804 30106458 654 0
hScc1 BcellGSE12603 30114360 30114687 327 0
hScc1 BcellGSE12603 30123230 30123514 284 0
hScc1 BcellGSE12603 30143569 30143874 305 0
hScc1 CdLSGSE12603 30143569 30143874 305 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved