AutismKB 2.0

Annotation Detail for HCLS1


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Basic Information Top
Gene Symbol:HCLS1 ( CTTNL,HS1 )
Gene Full Name: hematopoietic cell-specific Lyn substrate 1
Band: 3q13.33
Quick LinksEntrez ID:3059; OMIM: 601306; Uniprot ID:HCLS1_HUMAN; ENSEMBL ID: ENSG00000180353; HGNC ID: 4844
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
41N6-acetyllysine.
103Phosphotyrosine.
123N6-acetyllysine.
140Phosphotyrosine (By similarity).
192N6-acetyllysine.
198Phosphotyrosine.
222Phosphotyrosine.
241N6-acetyllysine.
275Phosphoserine.
308Phosphothreonine.
Location(AA) Modifications Resource
103Phosphotyrosine.Swiss-Prot 53.0
103PhosphotyrosinePhospho.ELM 6.0
198Phosphotyrosine.Swiss-Prot 53.0
198PhosphotyrosinePhospho.ELM 6.0
222Phosphotyrosine (Lyn;Fgr)Phospho.ELM 6.0
222Phosphotyrosine.Swiss-Prot 53.0
275Phosphoserine.Swiss-Prot 53.0
275PhosphoserinePhospho.ELM 6.0
360PhosphotyrosinePhospho.ELM 6.0
378Phosphotyrosine (Lyn;Syk)Phospho.ELM 6.0
397Phosphotyrosine (Lyn;Syk;Fgr)Phospho.ELM 6.0
Location(AA) Modification Resource
32Phosphoserine(CK2)HMM predict
112Phosphoserine(ATM)HMM predict
222Phosphotyrosine(Jak)HMM predict
272Phosphothreonine(PKC)HMM predict
275Phosphoserine(CDC2)HMM predict
308Phosphothreonine(CDK)HMM predict
311Phosphoserine(CK2)HMM predict
311O-linkedHMM predict
312O-linkedHMM predict
319Phosphothreonine(PKC)HMM predict
360Phosphotyrosine(Abl)HMM predict
360Phosphotyrosine(EGFR)HMM predict
360Phosphotyrosine(Syk)HMM predict
360PhosphotyrosineHMM predict
360Phosphotyrosine(SRC)HMM predict
378Phosphotyrosine(Syk)HMM predict
378Phosphotyrosine(SRC)HMM predict
378SulfotyrosineHMM predict
378Phosphotyrosine(EGFR)HMM predict
378PhosphotyrosineHMM predict
397Phosphotyrosine(SRC)HMM predict
397Phosphotyrosine(Syk)HMM predict
397SulfotyrosineHMM predict
409O-linkedHMM predict
439SulfotyrosineHMM predict
469ArginineHMM predict
470S-farnesylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005335
  • Location:chr3 122832936-122862404
  • strand:-
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 122838018 122838388 370 0
NFkBII GM12892GSE19485 122839080 122840234 1154 0
Nanog hESGSE18292 122845004 122845445 441 0
Oct1 HelaGSE14283 122834428 122834456 28 0
Oct1 HelaGSE14283 122842174 122842242 68 0
hScc1 BcellGSE12603 122862040 122862501 461 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018