Annotation Detail for HCRTR1

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Basic Information Top

Gene Symbol:	HCRTR1 ( OX1R )
Gene Full Name:	hypocretin (orexin) receptor 1
Band:	1p35.2
Quick Links	Entrez ID:3061; OMIM: 602392; Uniprot ID:OX1R_HUMAN; ENSEMBL ID: ENSG00000121764; HGNC ID: 4848
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:1 results
Predicted PTM Sites by profile HMM from dbPTM:14 results

Location(AA)	Modification
27	Phosphotyrosine.
194	N-linked (GlcNAc...) (Potential).

Location(AA)	Modification	Resource
6	Phosphothreonine(MAPK)	HMM predict
17	O-linked	HMM predict
21	Phosphoserine(CDK)	HMM predict
21	O-linked	HMM predict
21	Phosphoserine(IKK)	HMM predict
21	Phosphoserine(CDC2)	HMM predict
194	N-linked	HMM predict
200	Phosphoserine(PKB)	HMM predict
262	Phosphoserine(PKA)	HMM predict
296	Phosphothreonine(PKA)	HMM predict
337	Phosphotyrosine(EGFR)	HMM predict
390	Phosphoserine(MAPK)	HMM predict
390	Phosphoserine(CDK)	HMM predict
390	Phosphoserine(CDC2)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001525
Location:chr1 31857227-31865300
strand:+

Upstream the gene:6 results
Downstream the gene:0 results
Inside the gene:5 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	31853967	31854409	442	3040
CTCF	G2	GSE9613	31855551	31856759	1208	1073
Oct1	Hela	GSE14283	31856847	31856877	30	366
hScc1	Bcell	GSE12603	31853779	31854445	666	3116
hScc1	Bcell	GSE12603	31855625	31856759	1134	1036
hScc1	CdLS	GSE12603	31855793	31856759	966	952

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	31857893	31858271	378	0
CTCF	G2	GSE9613	31860423	31860930	507	0
CTCF	G2	GSE9613	31863429	31863624	195	0
Stat6	IL-4-hr4	GSE17850	31858981	31859535	554	0
TFAP2C	MCF7	GSE21234	31864480	31865193	713	0

Validated miRNA targets

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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