AutismKB 2.0

Annotation Detail for HDAC1


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Basic Information Top
Gene Symbol:HDAC1 ( DKFZp686H12203,GON-10,HD1,RPD3,RPD3L1 )
Gene Full Name: histone deacetylase 1
Band: 1p35.2-p35.1
Quick LinksEntrez ID:3065; OMIM: 601241; Uniprot ID:HDAC1_HUMAN; ENSEMBL ID: ENSG00000116478; HGNC ID: 4852
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
74N6-acetyllysine.
220N6-acetyllysine.
221Phosphotyrosine.
393Phosphoserine.
406Phosphoserine.
421Phosphoserine; by CK2.
423Phosphoserine; by CK2.
432N6-methylated lysine; by EHMT2.
Location(AA) Modifications Resource
221Phosphotyrosine.Swiss-Prot 53.0
393Phosphoserine.Swiss-Prot 53.0
393PhosphoserinePhospho.ELM 6.0
421Phosphoserine (by CK2).Swiss-Prot 53.0
421Phosphoserine (CK2
423Phosphoserine (by CK2).Swiss-Prot 53.0
423Phosphoserine (CK2
444Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
476Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
Location(AA) Modification Resource
7Phosphothreonine(PKC)HMM predict
24SulfotyrosineHMM predict
38Phosphothreonine(PKA)HMM predict
72Phosphotyrosine(EGFR)HMM predict
195Phosphothreonine(PKC)HMM predict
222Phosphotyrosine(INSR)HMM predict
237Phosphotyrosine(EGFR)HMM predict
237Phosphotyrosine(Syk)HMM predict
267Phosphoserine(CK1)HMM predict
275N-linkedHMM predict
349N-linkedHMM predict
352N-linkedHMM predict
354N-linkedHMM predict
393Phosphoserine(CK2)HMM predict
421PhosphoserineHMM predict
421Phosphoserine(ATM)HMM predict
421Phosphoserine(CK2)HMM predict
421Phosphoserine(CK1)HMM predict
423Phosphoserine(CK1)HMM predict
433N-linkedHMM predict
436N-linkedHMM predict
445Phosphothreonine(PKC)HMM predict
445Phosphothreonine(CK2)HMM predict
460Phosphothreonine(CK2)HMM predict
465Phosphothreonine(CK2)HMM predict
472AlanineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004964
  • Location:chr1 32530294-32571810
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 32529195 32530510 1315 442
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF HelaGSE12889 32554712 32554968 256 0
CTCF G2GSE9613 32530128 32530616 488 0
CTCF G2GSE9613 32554670 32554965 295 0
ER MCF7GSE19013 32570874 32571484 610 0
FOXA1 MCF7GSE15244 32548035 32548595 560 0
FOXA1 MCF7GSE15244 32559763 32560428 665 0
Fos K562GSE19551 32545497 32546034 537 0
H3ac HepG2E 32530450 32531199 749 0
H3ac HepG2E 32549671 32550152 481 0
H3ac HepG2E 32558441 32558654 213 0
Oct1 H2O2-HelaGSE14283 32560457 32560487 30 0
Oct1 HelaGSE14283 32560456 32560486 30 0
PHF8 HeLaGSE20725 32529758 32530906 1148 0
Stat6 IL-4-hr4GSE17850 32559617 32560342 725 0
TAF k562GSE8489 32530788 32531199 411 0
TFAP2C MCF7GSE21234 32570489 32571485 996 0
hScc1 BcellGSE12603 32530001 32531199 1198 0
hScc1 BcellGSE12603 32554670 32555092 422 0
hScc1 CdLSGSE12603 32554670 32555130 460 0
hScc1 CdLSGSE12603 32566784 32566991 207 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-449a hsa-mir-449a 5 20948989
hsa-miR-449a hsa-mir-449a 5 19252524
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
535 mRNA HDAC1 chr1 32426800 32468317 483 EST chr1 32467807 32468290Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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