AutismKB 2.0

Annotation Detail for HDC


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Basic Information Top
Gene Symbol:HDC ( MGC163399 )
Gene Full Name: histidine decarboxylase
Band: 15q21.2
Quick LinksEntrez ID:3067; OMIM: 142704; Uniprot ID:DCHS_HUMAN; ENSEMBL ID: ENSG00000140287; HGNC ID: 4855
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
305N6-(pyridoxal phosphate)lysine
Location(AA) Modifications Resource
Location(AA) Modification Resource
2AcetylmethionineHMM predict
7Phosphotyrosine(Syk)HMM predict
24Phosphothreonine(PKC)HMM predict
31Phosphothreonine(PKA)HMM predict
46Phosphoserine(ATM)HMM predict
53Phosphoserine(IKK)HMM predict
85O-linkedHMM predict
86Phosphoserine(IKK)HMM predict
140Phosphoserine(ATM)HMM predict
329Phosphoserine(ATM)HMM predict
481Phosphoserine(IKK)HMM predict
481Phosphoserine(CK1)HMM predict
554Phosphoserine(CK1)HMM predict
581Phosphothreonine(PKC)HMM predict
637Phosphotyrosine(Jak)HMM predict
647Phosphoserine(IKK)HMM predict
649S-farnesylHMM predict
655S-palmitoylHMM predict
656S-palmitoylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002112
  • Location:chr15 48321438-48345217
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 48320029 48320586 557 1131
P300 T0-glioblastomaGSE21026 48320230 48320586 356 1031
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 48335666 48335850 184 0
FOXA1 eGFPGSE10845 48335666 48335850 184 0
Gata2 K562GSE18868 48339833 48341193 1360 0
Oct1 HelaGSE14283 48336280 48336307 27 0
RARA MCF7GSE15244 48335666 48335850 184 0
TFAP2C MCF7GSE21234 48326969 48328105 1136 0
hScc1 BcellGSE12603 48327401 48327830 429 0
p130 SenescentGSE19898 48336608 48336916 308 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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