AutismKB 2.0

Annotation Detail for NRG1


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Basic Information Top
Gene Symbol:NRG1 ( ARIA,GGF,GGF2,HGL,HRG,HRG1,HRGA,MST131,NDF,SMDF )
Gene Full Name: neuregulin 1
Band: 8p12
Quick LinksEntrez ID:3084; OMIM: 142445; Uniprot ID:NRG1_HUMAN; ENSEMBL ID: ENSG00000157168; HGNC ID: 7997
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
120N-linked (GlcNAc...) (Potential).
126N-linked (GlcNAc...) (Potential).
164N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
120N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
126N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
164N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
30O-linkedHMM predict
30Phosphoserine(ATM)HMM predict
32Phosphoserine(IKK)HMM predict
44Phosphoserine(ATM)HMM predict
47Phosphoserine(IKK)HMM predict
63Phosphotyrosine(SRC)HMM predict
63Phosphotyrosine(INSR)HMM predict
110Phosphotyrosine(INSR)HMM predict
120N-linkedHMM predict
126N-linkedHMM predict
143O-linkedHMM predict
147Phosphotyrosine(EGFR)HMM predict
147Phosphotyrosine(SRC)HMM predict
152Phosphoserine(CDC2)HMM predict
157Phosphoserine(PKG)HMM predict
164N-linkedHMM predict
165O-linkedHMM predict
166O-linkedHMM predict
166O-linkedHMM predict
167O-linkedHMM predict
167Phosphoserine(CK1)HMM predict
167O-linkedHMM predict
168O-linkedHMM predict
168O-linkedHMM predict
168O-linkedHMM predict
169O-linkedHMM predict
170O-linkedHMM predict
170Phosphoserine(CK1)HMM predict
170Phosphoserine(IKK)HMM predict
171O-linkedHMM predict
172Phosphoserine(IKK)HMM predict
173O-linkedHMM predict
174O-linkedHMM predict
204N-linkedHMM predict
331Phosphoserine(IKK)HMM predict
331O-linkedHMM predict
333O-linkedHMM predict
335O-linkedHMM predict
335O-linkedHMM predict
339O-linkedHMM predict
344O-linkedHMM predict
344O-linkedHMM predict
346O-linkedHMM predict
348O-linkedHMM predict
350O-linkedHMM predict
350Phosphothreonine(MAPK)HMM predict
350Phosphothreonine(CDK)HMM predict
352Phosphoserine(MAPK)HMM predict
365Phosphoserine(CK1)HMM predict
382Phosphoserine(CK1)HMM predict
383Phosphoserine(PKB)HMM predict
383Phosphoserine(CDC2)HMM predict
391MethylarginineHMM predict
393N-linkedHMM predict
430Phosphothreonine(CDC2)HMM predict
441Phosphothreonine(CDC2)HMM predict
444Phosphoserine(CDC2)HMM predict
444Phosphoserine(CDK)HMM predict
447Phosphoserine(CDC2)HMM predict
447Phosphoserine(IKK)HMM predict
447Phosphoserine(MAPK)HMM predict
450O-linkedHMM predict
457O-linkedHMM predict
462Phosphoserine(IKK)HMM predict
500Phosphoserine(CDK)HMM predict
509Phosphoserine(IKK)HMM predict
511Phosphoserine(IKK)HMM predict
511Phosphoserine(CK1)HMM predict
515Phosphoserine(CDK)HMM predict
515Phosphoserine(CDC2)HMM predict
525Phosphotyrosine(INSR)HMM predict
525SulfotyrosineHMM predict
525Phosphotyrosine(Syk)HMM predict
531Phosphotyrosine(Syk)HMM predict
531Phosphotyrosine(SRC)HMM predict
565N-linkedHMM predict
567O-linkedHMM predict
567Phosphoserine(CK2)HMM predict
568Phosphoserine(ATM)HMM predict
568Phosphoserine(CK1)HMM predict
568Phosphoserine(IKK)HMM predict
571Phosphoserine(IKK)HMM predict
573Phosphoserine(CK1)HMM predict
575Phosphoserine(CK1)HMM predict
575Phosphoserine(CK2)HMM predict
577Phosphothreonine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004495
  • Location:chr8 32525294-32705675
  • strand:+
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 32526223 32526416 193 0
CTCF CD4SISSRdata 32526223 32526416 193 0
CTCF G2GSE9613 32524857 32526657 1800 0
CTCF G2GSE9613 32531764 32532176 412 0
H3K27me3 colorectalcancer 32526657 32527262 605 0
NRSF-mono JurkatQuESTdata 32623270 32623453 183 0
Oct1 H2O2-HelaGSE14283 32579914 32579956 42 0
Oct1 HelaGSE14283 32561047 32561083 36 0
Oct1 HelaGSE14283 32579914 32579956 42 0
Oct1 HelaGSE14283 32608018 32608048 30 0
PAX3-FKHR Rh4GSE19063 32526820 32529058 2238 0
STAT1 HeLaGSE12782 32607873 32609244 1371 0
STAT1 HeLaGSE12783 32607979 32609210 1231 0
hScc1 BcellGSE12603 32524934 32526617 1683 0
hScc1 BcellGSE12603 32531800 32532102 302 0
hScc1 CdLSGSE12603 32525081 32526699 1618 0
hScc1 CdLSGSE12603 32531764 32532176 412 0
hScc1 G2GSE9613 32524351 32526735 2384 0
hScc1 G2GSE9613 32531695 32532508 813 0
p63 keratinocytesGSE17611 32542605 32543565 960 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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