AutismKB 2.0

Annotation Detail for HK2


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Basic Information Top
Gene Symbol:HK2 ( DKFZp686M1669,HKII,HXK2 )
Gene Full Name: hexokinase 2
Band: 2p12
Quick LinksEntrez ID:3099; OMIM: 601125; Uniprot ID:HXK2_HUMAN; ENSEMBL ID: ENSG00000159399; HGNC ID: 4923
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
461Phosphotyrosine (By similarity).
Location(AA) Modifications Resource
Location(AA) Modification Resource
112Phosphotyrosine(Syk)HMM predict
112Phosphotyrosine(SRC)HMM predict
208N-linkedHMM predict
384Phosphoserine(IKK)HMM predict
384O-linkedHMM predict
384Phosphoserine(PKB)HMM predict
473Phosphothreonine(PKC)HMM predict
500Phosphoserine(CK1)HMM predict
588Phosphotyrosine(INSR)HMM predict
656N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000189
  • Location:chr2 74913289-74973981
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
RARA MCF7GSE15244 74893853 74894596 743 19065
TFAP2C MCF7GSE21234 74893579 74893939 360 19531
USF1 HepG2E 74901381 74901693 312 11753
USF1 HepG2E 74902076 74902643 567 10930
USF2 HepG2E 74893853 74894101 248 19313
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 74978105 74978303 198 4223
Oct1 H2O2-HelaGSE14283 74991841 74991873 32 17876
Oct1 HelaGSE14283 74989564 74989611 47 15606
Oct1 HelaGSE14283 74991841 74991872 31 17875
TAF k562GSE8489 74982128 74982530 402 8348
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 74956963 74957198 235 0
CTCF CD4SISSRdata 74956963 74957198 235 0
CTCF G2GSE9613 74914518 74915127 609 0
CTCF G2GSE9613 74915469 74916040 571 0
CTCF G2GSE9613 74917015 74917671 656 0
CTCF G2GSE9613 74925173 74925468 295 0
CTCF G2GSE9613 74935113 74935329 216 0
CTCF G2GSE9613 74945957 74946460 503 0
CTCF G2GSE9613 74954739 74955066 327 0
CTCF G2GSE9613 74956858 74957360 502 0
CTCF G2GSE9613 74960331 74960608 277 0
ER MCF7GSE19013 74924427 74924922 495 0
ER MCF7GSE19013 74925450 74927018 1568 0
FOXA1 MCF7GSE15244 74936328 74937607 1279 0
FOXA1 MCF7GSE15244 74945667 74947740 2073 0
FOXA1 MCF7GSE15244 74948046 74948979 933 0
FoxA1 MCF7MACSdata 74936849 74937248 399 0
FoxA1 MCF7MACSdata 74948563 74948916 353 0
H3K4me3 colorectalcancer 74916401 74917160 759 0
H3ac HepG2E 74916332 74918266 1934 0
H3ac HepG2E 74919488 74920167 679 0
HIF1 HypoHepG2 74914233 74915817 1584 0
Nanog hESGSE18292 74956997 74957275 278 0
Oct1 H2O2-HelaGSE14283 74950266 74950304 38 0
Oct1 H2O2-HelaGSE14283 74963108 74963139 31 0
Oct1 HelaGSE14283 74950266 74950301 35 0
Oct1 HelaGSE14283 74963107 74963142 35 0
Oct1 HelaGSE14283 74972338 74972365 27 0
PHF8 293TGSE20725 74915331 74916301 970 0
RARA MCF7GSE15244 74931475 74932426 951 0
RARA MCF7GSE15244 74948046 74948979 933 0
Rb GrowingGSE19898 74914676 74914832 156 0
Rb SenescentGSE19898 74916436 74916660 224 0
Sox2 hESGSE18292 74957017 74957189 172 0
TFAP2C MCF7GSE21234 74915855 74916762 907 0
TFAP2C MCF7GSE21234 74925781 74926695 914 0
TFAP2C MCF7GSE21234 74948345 74949216 871 0
TFAP2C MCF7GSE21234 74961794 74962222 428 0
USF1 HepG2E 74922187 74922545 358 0
USF1 HepG2E 74937013 74937607 594 0
USF2 HepG2E 74936845 74937426 581 0
hScc1 BcellGSE12603 74914518 74915505 987 0
hScc1 BcellGSE12603 74917160 74917600 440 0
hScc1 BcellGSE12603 74956525 74957397 872 0
hScc1 CdLSGSE12603 74956629 74957360 731 0
hScc1 G2GSE9613 74917089 74917441 352 0
hScc1 G2GSE9613 74925173 74925468 295 0
hScc1 G2GSE9613 74956525 74957431 906 0
p130 SenescentGSE19898 74914195 74914552 357 0
p130 SenescentGSE19898 74914619 74914840 221 0
p130 SenescentGSE19898 74915683 74915909 226 0
p130 shRbSenescentGSE19898 74914604 74914866 262 0
p63 keratinocytesGSE17611 74967962 74969247 1285 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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