AutismKB 2.0

Annotation Detail for APBB2


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Basic Information Top
Gene Symbol:APBB2 ( DKFZp434E033,FE65L,FE65L1,MGC35575 )
Gene Full Name: amyloid beta (A4) precursor protein-binding, family B, member 2
Band: 4p14-p13
Quick LinksEntrez ID:323; OMIM: 602710; Uniprot ID:APBB2_HUMAN; ENSEMBL ID: ENSG00000163697; HGNC ID: 582
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
336Phosphoserine.
339Phosphothreonine.
343Phosphothreonine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
27O-linkedHMM predict
31Phosphoserine(CDC2)HMM predict
34Phosphothreonine(MAPK)HMM predict
34Phosphothreonine(CDC2)HMM predict
60N-linkedHMM predict
82Phosphoserine(ATM)HMM predict
121N-linkedHMM predict
123Phosphoserine(CDC2)HMM predict
129N-linkedHMM predict
158Phosphothreonine(PKC)HMM predict
171Phosphoserine(CK2)HMM predict
190Phosphoserine(ATM)HMM predict
190Phosphoserine(CK1)HMM predict
229Phosphoserine(CDC2)HMM predict
229Phosphoserine(ATM)HMM predict
256Phosphoserine(CK2)HMM predict
269O-linkedHMM predict
271Phosphoserine(ATM)HMM predict
271Phosphoserine(IKK)HMM predict
271Phosphoserine(CDC2)HMM predict
271Phosphoserine(CDK)HMM predict
271Phosphoserine(MAPK)HMM predict
273Phosphoserine(CK2)HMM predict
274Phosphoserine(CDC2)HMM predict
274Phosphoserine(ATM)HMM predict
274Phosphoserine(IKK)HMM predict
322Phosphoserine(IKK)HMM predict
334Phosphoserine(PKA)HMM predict
334Phosphoserine(IKK)HMM predict
334Phosphoserine(CAMK2)HMM predict
334Phosphoserine(PKG)HMM predict
336O-linkedHMM predict
337O-linkedHMM predict
339O-linkedHMM predict
339Phosphothreonine(MAPK)HMM predict
339O-linkedHMM predict
341Phosphoserine(CDC2)HMM predict
341Phosphoserine(CDK)HMM predict
343O-linkedHMM predict
343Phosphothreonine(MAPK)HMM predict
471Phosphotyrosine(Jak)HMM predict
492Phosphoserine(ATM)HMM predict
581Phosphothreonine(MAPK)HMM predict
716Phosphoserine(ATM)HMM predict
734Phosphothreonine(PKA)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_173075
  • Location:chr4 40510995-40911244
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 40912946 40913770 824 2114
CTCF G2GSE9613 40913077 40913605 528 2097
CTCF G2GSE9613 40924538 40924710 172 13380
CTCF G2GSE9613 40929230 40929568 338 18155
H3K4me3 colorectalcancer 40912278 40912656 378 1223
H3ac HepG2E 40911633 40913234 1601 1189
PHF8 293TGSE20725 40912724 40913667 943 1951
RNAII Tamoxifen-MCF7GSE14664 40917685 40917772 87 6484
Rb SenescentGSE19898 40911154 40911453 299 59
hScc1 BcellGSE12603 40913077 40913470 393 2029
hScc1 CdLSGSE12603 40911077 40911776 699 182
p130 shRbQuiescentGSE19898 40913371 40913781 410 2332
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 40687187 40688040 853 0
CTCF CD4GSE12889 40537867 40538093 226 0
CTCF CD4GSE12889 40594477 40594638 161 0
CTCF CD4GSE12889 40605523 40605752 229 0
CTCF CD4GSE12889 40621387 40621584 197 0
CTCF CD4GSE12889 40624518 40624727 209 0
CTCF CD4SISSRdata 40537867 40538093 226 0
CTCF CD4SISSRdata 40594477 40594638 161 0
CTCF CD4SISSRdata 40605523 40605752 229 0
CTCF CD4SISSRdata 40621387 40621584 197 0
CTCF CD4SISSRdata 40624518 40624727 209 0
CTCF JurkatGSE12889 40605510 40605881 371 0
CTCF JurkatGSE12889 40621351 40621648 297 0
CTCF G2GSE9613 40519656 40520271 615 0
CTCF G2GSE9613 40522150 40522646 496 0
CTCF G2GSE9613 40529113 40529441 328 0
CTCF G2GSE9613 40532455 40532938 483 0
CTCF G2GSE9613 40533835 40534135 300 0
CTCF G2GSE9613 40537531 40538136 605 0
CTCF G2GSE9613 40538800 40539234 434 0
CTCF G2GSE9613 40539875 40541193 1318 0
CTCF G2GSE9613 40553747 40554158 411 0
CTCF G2GSE9613 40555612 40556036 424 0
CTCF G2GSE9613 40571836 40572018 182 0
CTCF G2GSE9613 40576765 40577042 277 0
CTCF G2GSE9613 40577514 40577727 213 0
CTCF G2GSE9613 40585324 40585511 187 0
CTCF G2GSE9613 40588489 40588672 183 0
CTCF G2GSE9613 40592117 40592548 431 0
CTCF G2GSE9613 40594343 40594758 415 0
CTCF G2GSE9613 40598080 40598251 171 0
CTCF G2GSE9613 40605159 40606121 962 0
CTCF G2GSE9613 40613263 40614222 959 0
CTCF G2GSE9613 40616229 40616516 287 0
CTCF G2GSE9613 40620216 40621049 833 0
CTCF G2GSE9613 40639571 40640151 580 0
CTCF G2GSE9613 40673148 40673509 361 0
CTCF G2GSE9613 40677100 40677411 311 0
CTCF G2GSE9613 40747763 40748020 257 0
CTCF G2GSE9613 40757404 40757778 374 0
CTCF G2GSE9613 40819656 40819975 319 0
CTCF G2GSE9613 40823169 40823331 162 0
CTCF G2GSE9613 40827239 40827803 564 0
CTCF G2GSE9613 40856887 40857070 183 0
CTCF G2GSE9613 40879775 40880022 247 0
CTCF G2GSE9613 40881130 40881380 250 0
CTCF G2GSE9613 40887740 40888034 294 0
CTCF G2GSE9613 40890299 40890555 256 0
CTCF G2GSE9613 40892272 40892614 342 0
CTCF G2GSE9613 40909286 40909815 529 0
CTCF G2GSE9613 40910477 40911995 1518 0
ER E2-MCF7GSE14664 40594193 40594227 34 0
ER E2-MCF7GSE14664 40900298 40900331 33 0
ER E2-MCF7GSE14664 40905500 40905533 33 0
ER E2-MCF7GSE14664 40906922 40906969 47 0
ER E2-MCF7GSE14664 40907838 40907870 32 0
ER Fulvestrant-MCF7GSE14664 40642013 40642086 73 0
ER Fulvestrant-MCF7GSE14664 40830623 40830664 41 0
ER MCF7GSE19013 40686238 40686827 589 0
ER MCF7GSE19013 40774307 40774780 473 0
ER MCF7GSE19013 40828801 40829559 758 0
FOXA1 MCF7GSE15244 40825753 40826487 734 0
FOXA1 MCF7GSE15244 40828872 40829583 711 0
FOXA1 eGFPGSE10845 40825753 40826487 734 0
FOXA1 eGFPGSE10845 40828872 40829583 711 0
Fos K562GSE19551 40905921 40906402 481 0
FoxA1 MCF7MACSdata 40826146 40826525 379 0
FoxA1 MCF7MACSdata 40829155 40829478 323 0
FoxA1 MCF7MACSdata 40832671 40832855 184 0
FoxA1 MCF7MACSdata 40873926 40874051 125 0
H3K4me3 colorectalcancer 40909708 40910222 514 0
H3ac HepG2E 40843866 40844225 359 0
H3ac HepG2E 40909093 40910477 1384 0
KLF4 hESGSE17917 40673340 40673501 161 0
Myc K562GSE19551 40537806 40538068 262 0
Myc K562GSE19551 40594368 40594649 281 0
Nanog ESGSE20650 40631413 40631920 507 0
Nanog ESGSE20650 40766545 40767015 470 0
Nanog hESGSE18292 40821559 40822161 602 0
Oct1 H2O2-HelaGSE14283 40623239 40623283 44 0
Oct1 H2O2-HelaGSE14283 40642017 40642079 62 0
Oct1 H2O2-HelaGSE14283 40792505 40792537 32 0
Oct1 H2O2-HelaGSE14283 40838490 40838520 30 0
Oct1 H2O2-HelaGSE14283 40869016 40869050 34 0
Oct1 HelaGSE14283 40616982 40617016 34 0
Oct1 HelaGSE14283 40623209 40623287 78 0
Oct1 HelaGSE14283 40642007 40642084 77 0
Oct1 HelaGSE14283 40645066 40645098 32 0
Oct1 HelaGSE14283 40652881 40652913 32 0
Oct1 HelaGSE14283 40671435 40671513 78 0
Oct1 HelaGSE14283 40679462 40679494 32 0
Oct1 HelaGSE14283 40691207 40691234 27 0
Oct1 HelaGSE14283 40705541 40705608 67 0
Oct1 HelaGSE14283 40770617 40770653 36 0
Oct1 HelaGSE14283 40792503 40792536 33 0
Oct1 HelaGSE14283 40830625 40830676 51 0
Oct1 HelaGSE14283 40838491 40838521 30 0
Oct1 HelaGSE14283 40869016 40869049 33 0
Oct1 HelaGSE14283 40900298 40900329 31 0
Oct1 HelaGSE14283 40906893 40907006 113 0
Oct1 HelaGSE14283 40907837 40907905 68 0
P300 T0-glioblastomaGSE21026 40606170 40606782 612 0
P300 T30-glioblastomaGSE21026 40605883 40606862 979 0
P300 T30-glioblastomaGSE21026 40686699 40688070 1371 0
P300 T30-glioblastomaGSE21026 40725196 40725808 612 0
PAX3-FKHR Rh4GSE19063 40839479 40841794 2315 0
RARA MCF7GSE15244 40538868 40540710 1842 0
RARA MCF7GSE15244 40828872 40829640 768 0
RARA MCF7GSE15244 40852292 40853374 1082 0
Rb GrowingGSE19898 40725492 40725703 211 0
TAF HelaGSE8489 40620502 40621049 547 0
TFAP2C MCF7GSE21234 40539769 40540252 483 0
TFAP2C MCF7GSE21234 40853759 40854134 375 0
TFAP2C MCF7GSE21234 40875099 40875537 438 0
VDR GM10855-stimGSE22484 40908745 40910231 1486 0
hScc1 BcellGSE12603 40530042 40530344 302 0
hScc1 BcellGSE12603 40537638 40538174 536 0
hScc1 BcellGSE12603 40540379 40540915 536 0
hScc1 BcellGSE12603 40553666 40554218 552 0
hScc1 BcellGSE12603 40556036 40556477 441 0
hScc1 BcellGSE12603 40575166 40575305 139 0
hScc1 BcellGSE12603 40605302 40606048 746 0
hScc1 BcellGSE12603 40673040 40673509 469 0
hScc1 BcellGSE12603 40677100 40677377 277 0
hScc1 BcellGSE12603 40819447 40819938 491 0
hScc1 BcellGSE12603 40909359 40909784 425 0
hScc1 BcellGSE12603 40910251 40911776 1525 0
hScc1 CdLSGSE12603 40540379 40540915 536 0
hScc1 CdLSGSE12603 40594386 40594758 372 0
hScc1 CdLSGSE12603 40677100 40677628 528 0
hScc1 CdLSGSE12603 40909286 40909949 663 0
hScc1 G2GSE9613 40605338 40606196 858 0
hScc1 G2GSE9613 40677100 40677555 455 0
hScc1 G2GSE9613 40909286 40911741 2455 0
p63 keratinocytesGSE17611 40828895 40829502 607 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
19602 EST chr4 40655723 40669096 81 mRNA APBB2 chr4 40657166 41057416Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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