AutismKB 2.0

Annotation Detail for HOXD8


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Basic Information Top
Gene Symbol:HOXD8 ( HOX4,HOX4E,HOX5.4 )
Gene Full Name: homeobox D8
Band: 2q31.1
Quick LinksEntrez ID:3234; OMIM: 142985; Uniprot ID:HXD8_HUMAN; ENSEMBL ID: ENSG00000175879; HGNC ID: 5139
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
28N-linkedHMM predict
32Phosphotyrosine(EGFR)HMM predict
75O-linkedHMM predict
75Phosphoserine(ATM)HMM predict
79O-linkedHMM predict
79O-linkedHMM predict
100Phosphoserine(CDC2)HMM predict
139Phosphotyrosine(INSR)HMM predict
164Phosphoserine(CK1)HMM predict
164Phosphoserine(IKK)HMM predict
177N-linkedHMM predict
181Phosphoserine(CDC2)HMM predict
181Phosphoserine(IKK)HMM predict
223Phosphothreonine(PKC)HMM predict
273Phosphothreonine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_019558
  • Location:chr2 176702722-176704971
  • strand:+
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 176713517 176713977 460 8776
CTCF CD4SISSRdata 176713517 176713977 460 8776
CTCF G2GSE9613 176707949 176708132 183 3069
CTCF G2GSE9613 176708809 176709092 283 3979
CTCF G2GSE9613 176709707 176709952 245 4858
CTCF G2GSE9613 176713602 176714207 605 8933
Rb QuiescentGSE19898 176713468 176713927 459 8726
Rb SenescentGSE19898 176713473 176713960 487 8745
hScc1 BcellGSE12603 176709550 176709952 402 4780
hScc1 BcellGSE12603 176713231 176713926 695 8607
hScc1 BcellGSE12603 176714207 176714733 526 9499
hScc1 CdLSGSE12603 176713231 176714172 941 8730
p130 shRbSenescentGSE19898 176713581 176713830 249 8734
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 176702742 176703481 739 0
Validated miRNA targets Top
No data
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
500 mRNA repression TRUE miR-196 HOXD8 in vitro reporter gene assay (Luciferase) 15105502
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000175879 n_a n_a n_a "epithelium, lymphocyte" malignant tumour
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018