Annotation Detail for HSPB1

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Basic Information Top

Gene Symbol:	HSPB1 ( CMT2F,DKFZp586P1322,HMN2B,HS.76067,HSP27,HSP28,Hsp25,SRP27 )
Gene Full Name:	heat shock 27kDa protein 1
Band:	7q11.23
Quick Links	Entrez ID:3315; OMIM: 602195; Uniprot ID:HSPB1_HUMAN; ENSEMBL ID: ENSG00000106211; HGNC ID: 5246
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:8 results
Experimental PTM Sites from dbPTM:14 results
Predicted PTM Sites by profile HMM from dbPTM:8 results

Location(AA)	Modification
15	Phosphoserine.
26	Phosphoserine (By similarity).
65	Phosphoserine.
78	Phosphoserine.
82	Phosphoserine.
83	Phosphoserine.
123	N6-acetyllysine.
199	Phosphoserine.

Location(AA)	Modifications	Resource
15	Phosphoserine.	Swiss-Prot 53.0
15	Phosphoserine (MAPKAPK2;PKA)	Phospho.ELM 6.0
26	Phosphoserine (By similarity).	Swiss-Prot 53.0
65	Phosphoserine.	Swiss-Prot 53.0
65	Phosphoserine	Phospho.ELM 6.0
78	Phosphoserine (MAPKAPK2;p70)	Phospho.ELM 6.0
78	Phosphoserine.	Swiss-Prot 53.0
82	Phosphoserine (PKD1;MAPKAPK)	Phospho.ELM 6.0
82	Phosphoserine.	Swiss-Prot 53.0
83	Phosphoserine.	Swiss-Prot 53.0
83	Phosphoserine	Phospho.ELM 6.0
86	Phosphoserine	Phospho.ELM 6.0
91	Phosphothreonine	Phospho.ELM 6.0
123	N6-acetyllysine.	Swiss-Prot 53.0

Location(AA)	Modification	Resource
15	Phosphoserine(PKA)	HMM predict
82	Phosphoserine(PKA)	HMM predict
133	Phosphotyrosine(INSR)	HMM predict
156	O-linked	HMM predict
158	Phosphoserine(CK1)	HMM predict
158	Phosphoserine(CDC2)	HMM predict
158	Phosphoserine(ATM)	HMM predict
158	Phosphoserine(IKK)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001540
Location:chr7 75769858-75771547
strand:+

Upstream the gene:7 results
Downstream the gene:13 results
Inside the gene:10 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
FOXA1	MCF7	GSE15244	75764670	75764913	243	5067
Oct1	H2O2-Hela	GSE14283	75763033	75763069	36	6808
Oct1	Hela	GSE14283	75763033	75763069	36	6808
Rb	Quiescent	GSE19898	75769613	75769943	330	81
Rb	Senescent	GSE19898	75769460	75769966	506	146
TFAP2C	MCF7	GSE21234	75767281	75767902	621	2267
hScc1	Bcell	GSE12603	75762725	75762994	269	6999

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	75781481	75781849	368	10118
CTCF	CD4	SISSRdata	75781481	75781849	368	10118
CTCF	Hela	GSE12889	75781592	75781881	289	10189
CTCF	G2	GSE9613	75774392	75774878	486	3088
CTCF	G2	GSE9613	75781289	75781838	549	10016
ER	MCF7	GSE19013	75774223	75775009	786	3069
ER	MCF7	GSE19013	75776992	75778121	1129	6009
TFAP2C	MCF7	GSE21234	75773643	75775195	1552	2872
TFAP2C	MCF7	GSE21234	75777388	75778521	1133	6407
hScc1	Bcell	GSE12603	75781289	75781838	549	10016
hScc1	CdLS	GSE12603	75781289	75781838	549	10016
hScc1	G2	GSE9613	75781289	75781838	549	10016
p130	Quiescent	GSE19898	75781622	75781789	167	10158

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	75769679	75770359	680	0
CTCF	G2	GSE9613	75770875	75771218	343	0
PHF8	HeLa	GSE20725	75769291	75771648	2357	0
Pol2	GM12878	GSE19551	75769528	75770383	855	0
Rb	Quiescent	GSE19898	75770906	75771143	237	0
Rb	Senescent	GSE19898	75770644	75771121	477	0
hScc1	Bcell	GSE12603	75769715	75770359	644	0
p130	shRbQuiescent	GSE19898	75770198	75770696	498	0
p130	shRbSenescent	GSE19898	75769661	75770168	507	0
p130	shRbSenescent	GSE19898	75770620	75771148	528	0

Validated miRNA targets

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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